| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 2885 |
Name | GRB2 |
Synonymous | growth factor receptor-bound protein 2;GRB2;growth factor receptor-bound protein 2 |
Definition | HT027|SH2/SH3 adapter GRB2|abundant SRC homology|epidermal growth factor receptor-binding protein GRB2|growth factor receptor-bound protein 3|protein Ash |
Position | 17q24-q25 |
Gene Type | protein-coding |
COSMIC somatic mutation [Top] | |||
Mutation (CDS; AA; Chr) | Site | Histology | Mutation Type |
|---|---|---|---|
c.350A>G; p.K117R; 17:75321777-75321777 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.531C>T; p.F177F; 17:75320491-75320491 |
breast | carcinoma; ductal_carcinoma | Substitution - coding silent |
c.467A>G; p.Q156R; 17:75321660-75321660 |
large_intestine; caecum | carcinoma; adenocarcinoma | Substitution - Missense |
c.158T>G; p.I53R; 17:75332718-75332718 |
lung | carcinoma; adenocarcinoma | Substitution - Missense |
c.554T>C; p.V185A; 17:75320468-75320468 |
large_intestine; caecum | carcinoma; adenocarcinoma | Substitution - Missense |
c.649G>A; p.V217I; 17:75320373-75320373 |
stomach | carcinoma; adenocarcinoma | Substitution - Missense |
c.25T>C; p.F9L; 17:75393604-75393604 |
large_intestine; rectum | carcinoma; adenocarcinoma | Substitution - Missense |
c.25T>C; p.F9L; 17:75393604-75393604 |
large_intestine; caecum | carcinoma; adenocarcinoma | Substitution - Missense |
c.25T>C; p.F9L; 17:75393604-75393604 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.25T>C; p.F9L; 17:75393604-75393604 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.25T>C; p.F9L; 17:75393604-75393604 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.25T>C; p.F9L; 17:75393604-75393604 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.602A>T; p.Q201L; 17:75320420-75320420 |
lung | carcinoma; adenocarcinoma | Substitution - Missense |
c.606C>T; p.T202T; 17:75320416-75320416 |
pituitary; craniopharyngeal_duct | craniopharyngioma; adamantinomatous | Substitution - coding silent |
c.244G>A; p.A82T; 17:75325953-75325953 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.357C>T; p.F119F; 17:75321770-75321770 |
skin | malignant_melanoma | Substitution - coding silent |
c.644G>A; p.R215Q; 17:75320378-75320378 |
breast | carcinoma | Substitution - Missense |
c.138C>T; p.G46G; 17:75332738-75332738 |
oesophagus; lower_third | carcinoma; adenocarcinoma | Substitution - coding silent |
c.346G>A; p.G116R; 17:75321781-75321781 |
large_intestine; caecum | carcinoma; adenocarcinoma | Substitution - Missense |
c.541G>A; p.D181N; 17:75320481-75320481 |
skin; head_neck | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.19T>G; p.Y7D; 17:75393610-75393610 |
stomach | carcinoma; adenocarcinoma | Substitution - Missense |
c.36T>A; p.T12T; 17:75393593-75393593 |
urinary_tract; bladder | carcinoma; transitional_cell_carcinoma | Substitution - coding silent |
c.36T>A; p.T12T; 17:75393593-75393593 |
urinary_tract; bladder | carcinoma | Substitution - coding silent |
c.573C>G; p.P191P; 17:75320449-75320449 |
urinary_tract; bladder | carcinoma | Substitution - coding silent |
c.636C>G; p.P212P; 17:75320386-75320386 |
lung | carcinoma; adenocarcinoma | Substitution - coding silent |
c.507C>T; p.P169P; 17:75320515-75320515 |
skin; head_neck | carcinoma; squamous_cell_carcinoma | Substitution - coding silent |
c.598G>A; p.G200R; 17:75320424-75320424 |
liver | carcinoma | Substitution - Missense |
c.598G>A; p.G200R; 17:75320424-75320424 |
liver | carcinoma | Substitution - Missense |
c.335G>A; p.R112Q; 17:75321792-75321792 |
skin | malignant_melanoma | Substitution - Missense |
c.242G>T; p.G81V; 17:75325955-75325955 |
large_intestine; caecum | carcinoma; adenocarcinoma | Substitution - Missense |
c.27C>A; p.F9L; 17:75393602-75393602 |
ovary | carcinoma; serous_carcinoma | Substitution - Missense |
c.460G>T; p.V154L; 17:75321667-75321667 |
lung | carcinoma; adenocarcinoma | Substitution - Missense |
c.469C>T; p.Q157*; 17:75320553-75320553 |
haematopoietic_and_lymphoid_tissue; central_nervous_system | lymphoid_neoplasm; primary_central_nervous_system_lymphoma | Substitution - Nonsense |
c.553G>A; p.V185I; 17:75320469-75320469 |
kidney | carcinoma; clear_cell_renal_cell_carcinoma | Substitution - Missense |
c.27C>T; p.F9F; 17:75393602-75393602 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - coding silent |
c.313G>A; p.V105M; 17:75321814-75321814 |
skin; trunk | malignant_melanoma | Substitution - Missense |
c.453A>G; p.I151M; 17:75321674-75321674 |
lung; right_upper_lobe | carcinoma; adenocarcinoma | Substitution - Missense |
c.380C>A; p.S127Y; 17:75321747-75321747 |
large_intestine; rectum | carcinoma; adenocarcinoma | Substitution - Missense |
c.481G>T; p.V161F; 17:75320541-75320541 |
lung; right_upper_lobe | carcinoma; adenocarcinoma | Substitution - Missense |
c.619C>T; p.R207C; 17:75320403-75320403 |
stomach | carcinoma; intestinal_adenocarcinoma | Substitution - Missense |
c.181T>G; p.F61V; 17:75326016-75326016 |
haematopoietic_and_lymphoid_tissue | lymphoid_neoplasm | Substitution - Missense |
c.555C>T; p.V185V; 17:75320467-75320467 |
ovary | carcinoma; serous_carcinoma | Substitution - coding silent |
c.390G>C; p.E130D; 17:75321737-75321737 |
ovary | carcinoma; serous_carcinoma | Substitution - Missense |
c.414A>G; p.T138T; 17:75321713-75321713 |
liver | carcinoma | Substitution - coding silent |
c.488C>A; p.A163D; 17:75320534-75320534 |
haematopoietic_and_lymphoid_tissue | lymphoid_neoplasm | Substitution - Missense |
c.414A>G; p.T138T; 17:75321713-75321713 |
liver | carcinoma | Substitution - coding silent |
c.414A>G; p.T138T; 17:75321713-75321713 |
liver | carcinoma | Substitution - coding silent |
c.414A>G; p.T138T; 17:75321713-75321713 |
liver | carcinoma | Substitution - coding silent |
c.636delC; p.V213fs*1; 17:75320386-75320386 |
large_intestine; colon | carcinoma; adenocarcinoma | Deletion - Frameshift |
c.238G>A; p.D80N; 17:75325959-75325959 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.446G>A; p.R149Q; 17:75321681-75321681 |
prostate | carcinoma; adenocarcinoma | Substitution - Missense |
c.283T>G; p.F95V; 17:75325914-75325914 |
breast | carcinoma; HER-positive_carcinoma | Substitution - Missense |
c.76A>G; p.K26E; 17:75393553-75393553 |
stomach | carcinoma; adenocarcinoma | Substitution - Missense |
c.275C>T; p.P92L; 17:75325922-75325922 |
lung | carcinoma; small_cell_carcinoma | Substitution - Missense |
c.196C>T; p.P66S; 17:75326001-75326001 |
skin | malignant_melanoma | Substitution - Missense |