Entrez Gene

Basic Information
Gene ID	5338
Name	PLD2
Synonymous	phospholipase D2;PLD2;phospholipase D2
Definition	PLD1C\|choline phosphatase 2\|hPLD2\|phosphatidylcholine-hydrolyzing phospholipase D2
Position	17p13.1
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.562T>C; p.F188L; 17:4809499-4809499	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.562T>C; p.F188L; 17:4809499-4809499	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.740A>G; p.Y247C; 17:4809909-4809909	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.676C>A; p.R226R; 17:4809752-4809752	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.390C>A; p.A130A; 17:4809106-4809106	prostate	carcinoma	Substitution - coding silent
c.419G>A; p.G140D; 17:4809135-4809135	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.1818C>A; p.V606V; 17:4818004-4818004	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.966G>A; p.R322R; 17:4810907-4810907	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.236C>T; p.S79F; 17:4808110-4808110	skin	malignant_melanoma	Substitution - Missense
c.810G>A; p.G270G; 17:4809979-4809979	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.2627G>A; p.R876Q; 17:4822689-4822689	prostate	carcinoma	Substitution - Missense
c.708G>A; p.R236R; 17:4809877-4809877	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1582+2T>C; p.?; 17:4816748-4816748	endometrium	carcinoma; endometrioid_carcinoma	Unknown
c.2245G>A; p.V749I; 17:4819155-4819155	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2112C>T; p.H704H; 17:4818596-4818596	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1291C>T; p.R431C; 17:4815770-4815770	skin	malignant_melanoma	Substitution - Missense
c.2613C>T; p.S871S; 17:4822675-4822675	skin	malignant_melanoma	Substitution - coding silent
c.1007G>A; p.R336Q; 17:4810948-4810948	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2613C>T; p.S871S; 17:4822675-4822675	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1434C>T; p.S478S; 17:4815913-4815913	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.918C>T; p.I306I; 17:4810859-4810859	skin	malignant_melanoma	Substitution - coding silent
c.2364C>T; p.A788A; 17:4819484-4819484	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2363C>T; p.A788V; 17:4819483-4819483	NS	malignant_melanoma	Substitution - Missense
c.68A>T; p.E23V; 17:4807840-4807840	skin	malignant_melanoma	Substitution - Missense
c.2363C>T; p.A788V; 17:4819483-4819483	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; hairy_cell_leukaemia	Substitution - Missense
c.2363C>T; p.A788V; 17:4819483-4819483	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; hairy_cell_leukaemia	Substitution - Missense
c.2154G>T; p.L718L; 17:4818804-4818804	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.28C>T; p.P10S; 17:4807800-4807800	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1461C>A; p.P487P; 17:4816625-4816625	liver	carcinoma; hepatocellular_carcinoma	Substitution - coding silent
c.629G>A; p.R210Q; 17:4809705-4809705	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.629G>A; p.R210Q; 17:4809705-4809705	stomach	adenocarcinoma	Substitution - Missense
c.2665_2666CC>TT; p.P889F; 17:4822727-4822728	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.38A>T; p.D13V; 17:4807810-4807810	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.390C>T; p.A130A; 17:4809106-4809106	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2578-9C>T; p.?; 17:4822631-4822631	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Unknown
c.777G>C; p.Q259H; 17:4809946-4809946	breast	carcinoma	Substitution - Missense
c.2655C>A; p.A885A; 17:4822717-4822717	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1173G>A; p.A391A; 17:4814711-4814711	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.96G>A; p.E32E; 17:4807868-4807868	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1573C>T; p.P525S; 17:4816737-4816737	skin	malignant_melanoma	Substitution - Missense
c.2625C>T; p.L875L; 17:4822687-4822687	skin	malignant_melanoma	Substitution - coding silent
c.60C>A; p.L20L; 17:4807832-4807832	thyroid	other; neoplasm	Substitution - coding silent
c.1834C>T; p.R612C; 17:4818020-4818020	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1267C>T; p.L423L; 17:4815569-4815569	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1721A>T; p.K574M; 17:4817165-4817165	skin	malignant_melanoma	Substitution - Missense
c.1721A>T; p.K574M; 17:4817165-4817165	skin	malignant_melanoma	Substitution - Missense
c.2102C>T; p.A701V; 17:4818586-4818586	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1459C>G; p.P487A; 17:4816623-4816623	oesophagus; middle_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1677C>T; p.F559F; 17:4817031-4817031	skin	malignant_melanoma	Substitution - coding silent
c.2102C>T; p.A701V; 17:4818586-4818586	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2102C>T; p.A701V; 17:4818586-4818586	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1369G>C; p.G457R; 17:4815848-4815848	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma	Substitution - Missense
c.2134C>T; p.R712C; 17:4818784-4818784	breast	carcinoma	Substitution - Missense
c.24C>T; p.L8L; 17:4807796-4807796	breast	carcinoma	Substitution - coding silent
c.1145G>A; p.R382K; 17:4814683-4814683	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.322C>T; p.Q108*; 17:4808355-4808355	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.2374G>A; p.E792K; 17:4819494-4819494	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1958T>C; p.V653A; 17:4818334-4818334	skin	malignant_melanoma	Substitution - Missense
c.615-1G>T; p.?; 17:4809690-4809690	large_intestine; caecum	carcinoma; adenocarcinoma	Unknown
c.1613_1614delTG; p.M538fs*102; 17:4816967-4816968	ovary	carcinoma; serous_carcinoma	Deletion - Frameshift
c.634C>T; p.R212C; 17:4809710-4809710	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.835G>A; p.G279S; 17:4810004-4810004	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1365G>T; p.L455L; 17:4815844-4815844	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.1256C>T; p.A419V; 17:4815558-4815558	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1256C>T; p.A419V; 17:4815558-4815558	skin	malignant_melanoma	Substitution - Missense
c.728C>T; p.S243F; 17:4809897-4809897	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1570C>T; p.R524W; 17:4816734-4816734	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1411C>T; p.R471*; 17:4815890-4815890	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.2583C>T; p.F861F; 17:4822645-4822645	breast	carcinoma	Substitution - coding silent
c.604C>T; p.R202C; 17:4809541-4809541	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2243C>T; p.P748L; 17:4819153-4819153	skin	malignant_melanoma	Substitution - Missense
c.2243C>T; p.P748L; 17:4819153-4819153	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2580C>T; p.I860I; 17:4822642-4822642	breast	carcinoma	Substitution - coding silent
c.1929C>T; p.F643F; 17:4818305-4818305	skin	malignant_melanoma	Substitution - coding silent
c.2580C>T; p.I860I; 17:4822642-4822642	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1069_1071delGAG; p.E358delE; 17:4814476-4814478	endometrium	carcinoma; endometrioid_carcinoma	Deletion - In frame
c.1467G>A; p.P489P; 17:4816631-4816631	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.342C>T; p.L114L; 17:4808375-4808375	cervix	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.256C>T; p.L86L; 17:4808289-4808289	breast	carcinoma	Substitution - coding silent
c.256C>T; p.L86L; 17:4808289-4808289	skin	malignant_melanoma	Substitution - coding silent
c.861-8C>G; p.?; 17:4810794-4810794	kidney	other; neoplasm	Unknown
c.2560G>A; p.A854T; 17:4821890-4821890	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.695G>A; p.R232H; 17:4809771-4809771	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1754C>A; p.S585Y; 17:4817198-4817198	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1137T>G; p.D379E; 17:4814675-4814675	skin	malignant_melanoma	Substitution - Missense
c.2503C>T; p.R835*; 17:4821833-4821833	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.701C>T; p.S234F; 17:4809777-4809777	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.357C>T; p.V119V; 17:4808390-4808390	skin	malignant_melanoma	Substitution - coding silent
c.285C>T; p.D95D; 17:4808318-4808318	skin	malignant_melanoma	Substitution - coding silent
c.382C>T; p.R128*; 17:4808415-4808415	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.2224G>T; p.G742*; 17:4819134-4819134	stomach	carcinoma; adenocarcinoma	Substitution - Nonsense
c.389C>T; p.A130V; 17:4809105-4809105	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2283C>T; p.I761I; 17:4819193-4819193	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.335G>A; p.R112Q; 17:4808368-4808368	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.2159G>A; p.R720H; 17:4818809-4818809	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2073C>A; p.I691I; 17:4818557-4818557	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2551G>A; p.E851K; 17:4821881-4821881	upper_aerodigestive_tract; pharynx	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2123G>A; p.R708K; 17:4818607-4818607	autonomic_ganglia	neuroblastoma	Substitution - Missense
c.2669C>T; p.P890L; 17:4822731-4822731	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; plasma_cell_myeloma	Substitution - Missense
c.2633A>T; p.Y878F; 17:4822695-4822695	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.2649C>T; p.P883P; 17:4822711-4822711	skin	malignant_melanoma	Substitution - coding silent
c.1952G>T; p.R651L; 17:4818328-4818328	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.846C>T; p.I282I; 17:4810015-4810015	skin	malignant_melanoma	Substitution - coding silent
c.43C>A; p.L15M; 17:4807815-4807815	thyroid	other; neoplasm	Substitution - Missense
c.1154T>C; p.I385T; 17:4814692-4814692	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.61C>G; p.Q21E; 17:4807833-4807833	thyroid	other; neoplasm	Substitution - Missense
c.269G>A; p.R90H; 17:4808302-4808302	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1536C>G; p.S512R; 17:4816700-4816700	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2526C>T; p.F842F; 17:4821856-4821856	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1823G>A; p.R608Q; 17:4818009-4818009	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1465C>T; p.P489S; 17:4816629-4816629	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1260G>A; p.L420L; 17:4815562-4815562	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.1365delG; p.G457fs*16; 17:4815844-4815844	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1365delG; p.G457fs*16; 17:4815844-4815844	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1365delG; p.G457fs*16; 17:4815844-4815844	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.2202C>T; p.S734S; 17:4819112-4819112	skin	malignant_melanoma	Substitution - coding silent
c.2202C>T; p.S734S; 17:4819112-4819112	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.384A>T; p.R128R; 17:4809100-4809100	liver	carcinoma; hepatocellular_carcinoma	Substitution - coding silent
c.2388G>A; p.T796T; 17:4819508-4819508	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.2715C>T; p.H905H; 17:4822777-4822777	skin	malignant_melanoma	Substitution - coding silent
c.2182G>C; p.A728P; 17:4819092-4819092	skin	malignant_melanoma	Substitution - Missense
c.1639G>A; p.V547I; 17:4816993-4816993	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1391G>A; p.R464H; 17:4815870-4815870	thyroid	carcinoma	Substitution - Missense
c.2460C>T; p.F820F; 17:4819580-4819580	skin	malignant_melanoma	Substitution - coding silent
c.2033A>G; p.Y678C; 17:4818517-4818517	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2420A>G; p.Q807R; 17:4819540-4819540	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.407C>T; p.A136V; 17:4809123-4809123	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.594G>A; p.P198P; 17:4809531-4809531	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.833A>T; p.H278L; 17:4810002-4810002	skin	malignant_melanoma	Substitution - Missense
c.1241G>A; p.G414D; 17:4815543-4815543	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2188C>T; p.R730W; 17:4819098-4819098	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.1241G>A; p.G414D; 17:4815543-4815543	upper_aerodigestive_tract; mouth	carcinoma	Substitution - Missense
c.534C>G; p.F178L; 17:4809342-4809342	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.410G>A; p.R137Q; 17:4809126-4809126	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.585C>A; p.S195S; 17:4809522-4809522	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.2773G>A; p.G925S; 17:4822835-4822835	prostate	carcinoma	Substitution - Missense
c.2045C>T; p.P682L; 17:4818529-4818529	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1504A>T; p.N502Y; 17:4816668-4816668	pleura	pulmonary_blastoma	Substitution - Missense
c.2471T>G; p.L824R; 17:4821801-4821801	skin	malignant_melanoma	Substitution - Missense
c.1988_2002del15; p.D663_K667delDRILK; 17:4818364-4818378	breast	carcinoma; ductal_carcinoma	Deletion - In frame
c.2609G>A; p.R870H; 17:4822671-4822671	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.2673G>T; p.L891F; 17:4822735-4822735	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2044C>T; p.P682S; 17:4818528-4818528	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.750C>T; p.L250L; 17:4809919-4809919	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.283G>A; p.D95N; 17:4808316-4808316	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.283G>A; p.D95N; 17:4808316-4808316	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2369T>C; p.L790P; 17:4819489-4819489	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.2370G>A; p.L790L; 17:4819490-4819490	liver	carcinoma; hepatocellular_carcinoma	Substitution - coding silent
c.1792G>A; p.G598R; 17:4817236-4817236	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2370G>A; p.L790L; 17:4819490-4819490	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1776C>T; p.L592L; 17:4817220-4817220	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.2151C>T; p.I717I; 17:4818801-4818801	skin	malignant_melanoma	Substitution - coding silent
c.445C>T; p.R149W; 17:4809161-4809161	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1083C>T; p.I361I; 17:4814490-4814490	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2078C>T; p.T693M; 17:4818562-4818562	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2461G>A; p.G821S; 17:4819581-4819581	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2461G>A; p.G821S; 17:4819581-4819581	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1895A>G; p.E632G; 17:4818081-4818081	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1895A>G; p.E632G; 17:4818081-4818081	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.359T>C; p.L120S; 17:4808392-4808392	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1895A>G; p.E632G; 17:4818081-4818081	thyroid	other; neoplasm	Substitution - Missense
c.1895A>G; p.E632G; 17:4818081-4818081	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.97G>C; p.G33R; 17:4807869-4807869	urinary_tract; bladder	carcinoma	Substitution - Missense
c.2419C>G; p.Q807E; 17:4819539-4819539	breast	carcinoma; ductal_carcinoma	Substitution - Missense
c.97G>C; p.G33R; 17:4807869-4807869	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.1651C>A; p.P551T; 17:4817005-4817005	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.1615C>T; p.P539S; 17:4816969-4816969	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.573C>T; p.V191V; 17:4809510-4809510	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.951C>T; p.F317F; 17:4810892-4810892	skin	malignant_melanoma	Substitution - coding silent
c.240G>A; p.K80K; 17:4808114-4808114	skin	malignant_melanoma	Substitution - coding silent
c.1730C>T; p.T577I; 17:4817174-4817174	thyroid	other; neoplasm	Substitution - Missense
c.1091G>T; p.W364L; 17:4814498-4814498	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.988C>T; p.R330W; 17:4810929-4810929	skin	malignant_melanoma	Substitution - Missense
c.988C>T; p.R330W; 17:4810929-4810929	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.628C>T; p.R210W; 17:4809704-4809704	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2244C>T; p.P748P; 17:4819154-4819154	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent

COSMIC somatic mutation [Top]