Entrez Gene

Basic Information
Gene ID	3566
Name	IL4R
Synonymous	interleukin 4 receptor;IL4R;interleukin 4 receptor
Definition	IL-4 receptor subunit alpha\|IL4R nirs variant 1\|interleukin-4 receptor alpha chain\|interleukin-4 receptor subunit alpha
Position	16p12.1-p11.2
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.1468G>A; p.V490I; 16:27362820-27362820	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1747G>A; p.E583K; 16:27363099-27363099	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2197G>T; p.G733C; 16:27363549-27363549	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.174C>T; p.L58L; 16:27342224-27342224	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1475C>T; p.A492V; 16:27362827-27362827	biliary_tract; gallbladder	carcinoma; adenocarcinoma	Substitution - Missense
c.2462A>G; p.Y821C; 16:27363814-27363814	breast	carcinoma	Substitution - Missense
c.170A>G; p.E57G; 16:27342220-27342220	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1312A>G; p.S438G; 16:27362664-27362664	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.1449T>G; p.T483T; 16:27362801-27362801	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.516C>T; p.F172F; 16:27352542-27352542	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.664C>T; p.H222Y; 16:27352690-27352690	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1666C>T; p.R556*; 16:27363018-27363018	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Nonsense
c.426C>T; p.T142T; 16:27346531-27346531	stomach	adenocarcinoma	Substitution - coding silent
c.362-5C>T; p.?; 16:27346462-27346462	lung	carcinoma; squamous_cell_carcinoma	Unknown
c.426C>T; p.T142T; 16:27346531-27346531	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.144G>A; p.M48I; 16:27342194-27342194	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.144G>A; p.M48I; 16:27342194-27342194	urinary_tract; bladder	carcinoma	Substitution - Missense
c.345C>T; p.F115F; 16:27345004-27345004	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.2255C>T; p.S752F; 16:27363607-27363607	skin	malignant_melanoma	Substitution - Missense
c.1729G>A; p.E577K; 16:27363081-27363081	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.2055G>A; p.K685K; 16:27363407-27363407	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.2055G>A; p.K685K; 16:27363407-27363407	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1242G>T; p.L414L; 16:27362594-27362594	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1584C>T; p.P528P; 16:27362936-27362936	pancreas	carcinoma	Substitution - coding silent
c.1460C>T; p.T487M; 16:27362812-27362812	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.761G>A; p.S254N; 16:27355898-27355898	breast	carcinoma	Substitution - Missense
c.587C>T; p.S196F; 16:27352613-27352613	skin	malignant_melanoma	Substitution - Missense
c.587C>T; p.S196F; 16:27352613-27352613	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.587C>T; p.S196F; 16:27352613-27352613	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1667G>A; p.R556Q; 16:27363019-27363019	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1667G>A; p.R556Q; 16:27363019-27363019	skin	malignant_melanoma	Substitution - Missense
c.2105C>T; p.P702L; 16:27363457-27363457	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2382C>T; p.S794S; 16:27363734-27363734	skin	malignant_melanoma	Substitution - coding silent
c.874C>T; p.R292*; 16:27360790-27360790	prostate	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1757G>A; p.G586D; 16:27363109-27363109	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1313G>T; p.S438I; 16:27362665-27362665	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.1508C>T; p.S503F; 16:27362860-27362860	skin	malignant_melanoma	Substitution - Missense
c.2346C>T; p.P782P; 16:27363698-27363698	skin	malignant_melanoma	Substitution - coding silent
c.1884A>G; p.E628E; 16:27363236-27363236	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1776G>T; p.V592V; 16:27363128-27363128	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.2390C>T; p.P797L; 16:27363742-27363742	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.738C>T; p.A246A; 16:27355875-27355875	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.559G>A; p.A187T; 16:27352585-27352585	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.709G>A; p.V237I; 16:27355846-27355846	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.881A>G; p.Q294R; 16:27360797-27360797	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2199T>G; p.G733G; 16:27363551-27363551	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.1304C>G; p.P435R; 16:27362656-27362656	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.455A>G; p.Y152C; 16:27346560-27346560	breast	carcinoma	Substitution - Missense
c.2143G>C; p.A715P; 16:27363495-27363495	breast	carcinoma	Substitution - Missense
c.409G>A; p.D137N; 16:27346514-27346514	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.957A>G; p.K319K; 16:27362309-27362309	bone; extraskeletal	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.2331G>A; p.P777P; 16:27363683-27363683	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.725T>A; p.I242N; 16:27355862-27355862	haematopoietic_and_lymphoid_tissue; lymph_node	lymphoid_neoplasm; diffuse_large_B_cell_lymphoma	Substitution - Missense
c.2434G>A; p.V812M; 16:27363786-27363786	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma	Substitution - Missense
c.725T>A; p.I242N; 16:27355862-27355862	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	Substitution - Missense
c.687C>T; p.F229F; 16:27355824-27355824	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.2260C>T; p.P754S; 16:27363612-27363612	breast	carcinoma	Substitution - Missense
c.1213C>T; p.R405W; 16:27362565-27362565	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1805G>C; p.G602A; 16:27363157-27363157	breast	carcinoma	Substitution - Missense
c.2203C>T; p.Q735*; 16:27363555-27363555	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Nonsense
c.2356T>C; p.S786P; 16:27363708-27363708	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1199A>C; p.E400A; 16:27362551-27362551	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1199A>C; p.E400A; 16:27362551-27362551	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1199A>C; p.E400A; 16:27362551-27362551	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.1199A>C; p.E400A; 16:27362551-27362551	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.1374C>T; p.P458P; 16:27362726-27362726	biliary_tract; gallbladder	carcinoma; adenocarcinoma	Substitution - coding silent
c.1060G>T; p.E354*; 16:27362412-27362412	oesophagus	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1361A>T; p.K454M; 16:27362713-27362713	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1114_1116delGAG; p.E376delE; 16:27362466-27362468	skin	malignant_melanoma	Deletion - In frame
c.1301C>T; p.P434L; 16:27362653-27362653	skin	malignant_melanoma	Substitution - Missense
c.1079G>A; p.R360Q; 16:27362431-27362431	pancreas	carcinoma	Substitution - Missense
c.466C>G; p.H156D; 16:27346571-27346571	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.169G>A; p.E57K; 16:27342219-27342219	skin	malignant_melanoma	Substitution - Missense
c.2281G>A; p.A761T; 16:27363633-27363633	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.2443G>T; p.V815F; 16:27363795-27363795	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.102C>T; p.C34C; 16:27342152-27342152	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.971C>A; p.P324H; 16:27362323-27362323	breast	carcinoma	Substitution - Missense
c.244G>A; p.A82T; 16:27344903-27344903	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.882_883GG>TA; p.Q294_E295>HK; 16:27360798-27360799	skin; head_neck	carcinoma; squamous_cell_carcinoma	Complex - compound substitution
c.1806T>A; p.G602G; 16:27363158-27363158	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1299T>C; p.L433L; 16:27362651-27362651	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.341C>T; p.S114F; 16:27345000-27345000	skin	malignant_melanoma	Substitution - Missense
c.363G>A; p.V121V; 16:27346468-27346468	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.2258C>T; p.S753L; 16:27363610-27363610	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.417G>T; p.L139L; 16:27346522-27346522	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1678C>T; p.Q560*; 16:27363030-27363030	skin; face	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.1291T>C; p.C431R; 16:27362643-27362643	haematopoietic_and_lymphoid_tissue; lymph_node	lymphoid_neoplasm; acute_lymphoblastic_leukaemia	Substitution - Missense
c.1702G>A; p.V568I; 16:27363054-27363054	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1820C>A; p.S607*; 16:27363172-27363172	lung	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.85T>C; p.L29L; 16:27342135-27342135	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.135G>A; p.E45E; 16:27342185-27342185	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1727A>G; p.Q576R; 16:27363079-27363079	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.598C>T; p.R200W; 16:27352624-27352624	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.598C>T; p.R200W; 16:27352624-27352624	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.731T>A; p.I244N; 16:27355868-27355868	breast	carcinoma	Substitution - Missense
c.1252G>A; p.E418K; 16:27362604-27362604	urinary_tract; bladder	carcinoma	Substitution - Missense
c.2348C>T; p.S783L; 16:27363700-27363700	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.540A>G; p.L180L; 16:27352566-27352566	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.154A>G; p.T52A; 16:27342204-27342204	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.154A>G; p.T52A; 16:27342204-27342204	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1103C>G; p.P368R; 16:27362455-27362455	skin	malignant_melanoma	Substitution - Missense
c.1258G>C; p.G420R; 16:27362610-27362610	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.223A>G; p.I75V; 16:27344882-27344882	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.2272C>T; p.P758S; 16:27363624-27363624	skin	malignant_melanoma	Substitution - Missense
c.223A>G; p.I75V; 16:27344882-27344882	thyroid	other; neoplasm	Substitution - Missense
c.1461G>A; p.T487T; 16:27362813-27362813	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - coding silent
c.2083C>T; p.P695S; 16:27363435-27363435	skin	malignant_melanoma	Substitution - Missense
c.223A>G; p.I75V; 16:27344882-27344882	thyroid	other; neoplasm	Substitution - Missense
c.1470C>T; p.V490V; 16:27362822-27362822	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.679G>A; p.E227K; 16:27355816-27355816	skin	malignant_melanoma	Substitution - Missense
c.2263C>A; p.P755T; 16:27363615-27363615	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2135T>C; p.V712A; 16:27363487-27363487	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2010C>A; p.L670L; 16:27363362-27363362	thyroid	other; neoplasm	Substitution - coding silent
c.109G>A; p.D37N; 16:27342159-27342159	breast	carcinoma	Substitution - Missense
c.1290A>G; p.S430S; 16:27362642-27362642	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1863_1864insT; p.G623fs*3; 16:27363215-27363216	lung	carcinoma; adenocarcinoma	Insertion - Frameshift
c.1293C>T; p.C431C; 16:27362645-27362645	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.812G>T; p.R271L; 16:27358957-27358957	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1721G>T; p.G574V; 16:27363073-27363073	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1117G>T; p.E373*; 16:27362469-27362469	lung	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.759C>T; p.V253V; 16:27355896-27355896	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.2409G>A; p.Q803Q; 16:27363761-27363761	breast	carcinoma	Substitution - coding silent
c.554G>A; p.R185H; 16:27352580-27352580	oesophagus	carcinoma	Substitution - Missense
c.117G>T; p.M39I; 16:27342167-27342167	skin	malignant_melanoma	Substitution - Missense
c.1898C>T; p.P633L; 16:27363250-27363250	skin	malignant_melanoma	Substitution - Missense
c.2224C>T; p.P742S; 16:27363576-27363576	skin	malignant_melanoma	Substitution - Missense
c.1764G>A; p.Q588Q; 16:27363116-27363116	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.1072G>A; p.V358M; 16:27362424-27362424	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.218C>T; p.T73M; 16:27344877-27344877	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2046delG; p.E684fs*3; 16:27363398-27363398	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1755T>C; p.G585G; 16:27363107-27363107	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.596C>T; p.A199V; 16:27352622-27352622	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.108C>T; p.S36S; 16:27342158-27342158	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1564C>T; p.H522Y; 16:27362916-27362916	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.108C>T; p.S36S; 16:27342158-27342158	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.146A>G; p.N49S; 16:27342196-27342196	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.10C>A; p.L4I; 16:27340213-27340213	ovary	carcinoma	Substitution - Missense
c.2011C>T; p.P671S; 16:27363363-27363363	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.2194G>A; p.D732N; 16:27363546-27363546	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma	Substitution - Missense
c.1649G>T; p.W550L; 16:27363001-27363001	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2209C>T; p.P737S; 16:27363561-27363561	skin; mucosal	malignant_melanoma	Substitution - Missense
c.342C>A; p.S114S; 16:27345001-27345001	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.219G>A; p.T73T; 16:27344878-27344878	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.219G>A; p.T73T; 16:27344878-27344878	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.379G>T; p.G127*; 16:27346484-27346484	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.500A>T; p.N167I; 16:27346605-27346605	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1507T>C; p.S503P; 16:27362859-27362859	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1507T>C; p.S503P; 16:27362859-27362859	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1507T>C; p.S503P; 16:27362859-27362859	thyroid	other; neoplasm	Substitution - Missense
c.125C>G; p.S42C; 16:27342175-27342175	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.125C>G; p.S42C; 16:27342175-27342175	lung	carcinoma; bronchioloalveolar_adenocarcinoma	Substitution - Missense
c.899+1G>A; p.?; 16:27360816-27360816	central_nervous_system; brain	glioma	Unknown
c.1476A>T; p.A492A; 16:27362828-27362828	breast	carcinoma	Substitution - coding silent
c.99C>T; p.T33T; 16:27342149-27342149	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1117G>A; p.E373K; 16:27362469-27362469	liver	carcinoma	Substitution - Missense
c.2271C>T; p.T757T; 16:27363623-27363623	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1391C>A; p.P464H; 16:27362743-27362743	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1007C>G; p.S336C; 16:27362359-27362359	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.151C>T; p.P51S; 16:27342201-27342201	skin	malignant_melanoma	Substitution - Missense
c.1193G>C; p.G398A; 16:27362545-27362545	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.818G>A; p.R273H; 16:27358963-27358963	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.243C>T; p.G81G; 16:27344902-27344902	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1024T>C; p.C342R; 16:27362376-27362376	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1308G>A; p.S436S; 16:27362660-27362660	bone; tibia	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.1424C>G; p.P475R; 16:27362776-27362776	breast	carcinoma; basal_(triple-negative)_carcinoma	Substitution - Missense
c.2375C>A; p.S792*; 16:27363727-27363727	adrenal_gland; adrenal_gland	adrenal_cortical_carcinoma; functioning	Substitution - Nonsense
c.238G>T; p.G80*; 16:27344897-27344897	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1922G>T; p.C641F; 16:27363274-27363274	stomach	carcinoma; diffuse_adenocarcinoma	Substitution - Missense

COSMIC somatic mutation [Top]