| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 3566 |
Name | IL4R |
Synonym | CD124|IL-4RA|IL4RA;interleukin 4 receptor;IL4R;interleukin 4 receptor |
Definition | IL-4 receptor subunit alpha|IL4R nirs variant 1|interleukin-4 receptor alpha chain|interleukin-4 receptor subunit alpha |
Position | 16p12.1-p11.2 |
Gene Type | protein-coding |
Pathways and Diseases | |
Pathway | Jak-STAT signaling pathway;KEGG PATHWAY;hsa04630 |
Pathway | IL4-mediated signaling events;PID Curated;200018 |
Pathway | il 4 signaling pathway;PID BioCarta;100127 |
Pathway | Cytokine-cytokine receptor interaction;KEGG PATHWAY;hsa04060 |
Pathway | Hematopoietic cell lineage;KEGG PATHWAY;hsa04640 |
Pathway | Interleukin signaling pathway;PANTHER;P00036 |
Disease | Lupus erythematosus;FunDO |
Disease | atopy;GAD |
Disease | eczema;GAD |
Disease | Atopic Eczema;GAD |
Disease | HIV;GAD |
Disease | Hemolytic-Uremic syndrome;FunDO |
Disease | Asthma;FunDO |
Disease | Psoriasis;FunDO |
Disease | AGING;GAD |
Disease | Malignant glioma;FunDO |
Disease | Normal volunteers;GAD |
Disease | Diabetes mellitus;FunDO |
Disease | vascular disease;GAD |
Disease | Dermatitis;FunDO |
Disease | IMMUNE;GAD |
Disease | Atopy, susceptibility to;OMIM |
Disease | adult atopic dermatitis;GAD |
Disease | osteoarthritis;GAD |
Disease | PHARMACOGENOMIC;GAD |
Disease | Asthma;GAD |
Disease | METABOLIC;GAD |
Disease | rheumatoid arthritis;GAD |
Disease | atopy and influence the signal transduction;GAD |
Disease | INFECTION;GAD |
Disease | Hyper-IgE syndrome. severe eczema. atopy;GAD |
Disease | Dermatitis, Atopic;GAD |
Disease | allergic reaction, betalactam;GAD |
Disease | Autoimmune disease;FunDO |
Disease | Gastritis;FunDO |
Disease | Hamman-Rich syndrome;FunDO |
Disease | Asthma;KEGG DISEASE;H00079 |
Disease | diabetes, type 1;GAD |
Disease | asthma bronchodilator response IgE lung function;GAD |
Disease | hyper-IgE syndrome and severe eczema. atopy;GAD |
Disease | CARDIOVASCULAR;GAD |
Disease | Atopy (IgE);GAD |
Disease | multiple sclerosis(PPmultiple sclerosis);GAD |
Disease | Pancreas cancer;FunDO |
Disease | CANCER;GAD |
Disease | Total serum IgE;GAD |
Disease | Crohn's disease;GAD |
Disease | AIDS, slow progression to;OMIM |
Disease | Graves' disease IgE;GAD |
Disease | Necrotizing enterocolitis;FunDO |
Disease | Virus disease;FunDO |
Disease | Lymphoma, Large B-Cell, Diffuse;GAD |
Disease | Hodgkin lymphoma;GAD |
Disease | Allergic asthma;GAD |
Disease | Immune system diseases;KEGG DISEASE |
Disease | allele frequency/ normal;GAD |
Disease | Allergies and autoimmune diseases;KEGG DISEASE |
Disease | obesity;GAD |
Disease | IL-4;GAD |
Disease | increasing risk and a poor prognosis of renal cell carcinoma;GAD |
External Links | |
Links to Entrez Gene | 3566 |
Links to all GeneRIF Items | 3566 |
Links to iHOP | 3566 |
Sequence Information | |
Nucleotide Sequence | >3566 : length: 4114 GTTTGTCTGCTTCTGGGGTTCAAGGAATGCCCCCAGGCCAGCGCTAACCCTGCTCCAGTT CTAGTCTCTCCCCTTCCCCAGCCCTCTGGGAGGCATGACCCACTGCACTTCCCTGCCCCC AGTAGCCTATGAGGAGCCCAAGGCATTTGCTGGGACCTCAGTGCCTTTATCAAAATCCCA AAGTCCAATGGGGAAACAGGCTCAGGTGTAGGTTTGGCCAGGGTGTCCTGCACATTAGGG CATTCCAGGGTCCTGCAGGGGTTTCTTAGAACTCGGCTAGCCCAGCCCATGAATGGGAGG TGACCTGCTAAGCCACTCATTCACTCACTAGCACTCATTCAGCTCCTGCGAGGCCCTGGG TGGTGTTCTGGGCACTGGTGCTTGCCTCAAGGAGCACCCCCTCTGCAGGAAGACAGACGT GAGGGCTGGGAGGGTGCGGATGCACCAGCGGCTGCAGGACCACAAGCCAGAGGGGATCAG CTCTTCAAAGGTCACTGGGCCAGGCTTCCCAGCACCCAGGGACCCTGAGCTAGCCTTATA ATTAAAGATTTACACACAGCTGGAAGAAATCATAGAGAAGCCGGGCGTGGTGGCTCATGC CTATAATCCCAGCACTTTTGGAGGCTGAGGCGGGCAGATCACTTGAGATCAGGAGTTCGA GACCAGCCTGGTGCCTTGGCATCTCCCAATGGGGTGGCTTTGCTCTGGGCTCCTGTTCCC TGTGAGCTGCCTGGTCCTGCTGCAGGTGGCAAGCTCTGGGAACATGAAGGTCTTGCAGGA GCCCACCTGCGTCTCCGACTACATGAGCATCTCTACTTGCGAGTGGAAGATGAATGGTCC CACCAATTGCAGCACCGAGCTCCGCCTGTTGTACCAGCTGGTTTTTCTGCTCTCCGAAGC CCACACGTGTATCCCTGAGAACAACGGAGGCGCGGGGTGCGTGTGCCACCTGCTCATGGA TGACGTGGTCAGTGCGGATAACTATACACTGGACCTGTGGGCTGGGCAGCAGCTGCTGTG GAAGGGCTCCTTCAAGCCCAGCGAGCATGTGAAACCCAGGGCCCCAGGAAACCTGACAGT TCACACCAATGTCTCCGACACTCTGCTGCTGACCTGGAGCAACCCGTATCCCCCTGACAA TTACCTGTATAATCATCTCACCTATGCAGTCAACATTTGGAGTGAAAACGACCCGGCAGA TTTCAGAATCTATAACGTGACCTACCTAGAACCCTCCCTCCGCATCGCAGCCAGCACCCT GAAGTCTGGGATTTCCTACAGGGCACGGGTGAGGGCCTGGGCTCAGTGCTATAACACCAC CTGGAGTGAGTGGAGCCCCAGCACCAAGTGGCACAACTCCTACAGGGAGCCCTTCGAGCA GCACCTCCTGCTGGGCGTCAGCGTTTCCTGCATTGTCATCCTGGCCGTCTGCCTGTTGTG CTATGTCAGCATCACCAAGATTAAGAAAGAATGGTGGGATCAGATTCCCAACCCAGCCCG CAGCCGCCTCGTGGCTATAATAATCCAGGATGCTCAGGGGTCACAGTGGGAGAAGCGGTC CCGAGGCCAGGAACCAGCCAAGTGCCCACACTGGAAGAATTGTCTTACCAAGCTCTTGCC CTGTTTTCTGGAGCACAACATGAAAAGGGATGAAGATCCTCACAAGGCTGCCAAAGAGAT GCCTTTCCAGGGCTCTGGAAAATCAGCATGGTGCCCAGTGGAGATCAGCAAGACAGTCCT CTGGCCAGAGAGCATCAGCGTGGTGCGATGTGTGGAGTTGTTTGAGGCCCCGGTGGAGTG TGAGGAGGAGGAGGAGGTAGAGGAAGAAAAAGGGAGCTTCTGTGCATCGCCTGAGAGCAG CAGGGATGACTTCCAGGAGGGAAGGGAGGGCATTGTGGCCCGGCTAACAGAGAGCCTGTT CCTGGACCTGCTCGGAGAGGAGAATGGGGGCTTTTGCCAGCAGGACATGGGGGAGTCATG CCTTCTTCCACCTTCGGGAAGTACGAGTGCTCACATGCCCTGGGATGAGTTCCCAAGTGC AGGGCCCAAGGAGGCACCTCCCTGGGGCAAGGAGCAGCCTCTCCACCTGGAGCCAAGTCC TCCTGCCAGCCCGACCCAGAGTCCAGACAACCTGACTTGCACAGAGACGCCCCTCGTCAT CGCAGGCAACCCTGCTTACCGCAGCTTCAGCAACTCCCTGAGCCAGTCACCGTGTCCCAG AGAGCTGGGTCCAGACCCACTGCTGGCCAGACACCTGGAGGAAGTAGAACCCGAGATGCC CTGTGTCCCCCAGCTCTCTGAGCCAACCACTGTGCCCCAACCTGAGCCAGAAACCTGGGA GCAGATCCTCCGCCGAAATGTCCTCCAGCATGGGGCAGCTGCAGCCCCCGTCTCGGCCCC CACCAGTGGCTATCAGGAGTTTGTACATGCGGTGGAGCAGGGTGGCACCCAGGCCAGTGC GGTGGTGGGCTTGGGTCCCCCAGGAGAGGCTGGTTACAAGGCCTTCTCAAGCCTGCTTGC CAGCAGTGCTGTGTCCCCAGAGAAATGTGGGTTTGGGGCTAGCAGTGGGGAAGAGGGGTA TAAGCCTTTCCAAGACCTCATTCCTGGCTGCCCTGGGGACCCTGCCCCAGTCCCTGTCCC CTTGTTCACCTTTGGACTGGACAGGGAGCCACCTCGCAGTCCGCAGAGCTCACATCTCCC AAGCAGCTCCCCAGAGCACCTGGGTCTGGAGCCGGGGGAAAAGGTAGAGGACATGCCAAA GCCCCCACTTCCCCAGGAGCAGGCCACAGACCCCCTTGTGGACAGCCTGGGCAGTGGCAT TGTCTACTCAGCCCTTACCTGCCACCTGTGCGGCCACCTGAAACAGTGTCATGGCCAGGA GGATGGTGGCCAGACCCCTGTCATGGCCAGTCCTTGCTGTGGCTGCTGCTGTGGAGACAG GTCCTCGCCCCCTACAACCCCCCTGAGGGCCCCAGACCCCTCTCCAGGTGGGGTTCCACT GGAGGCCAGTCTGTGTCCGGCCTCCCTGGCACCCTCGGGCATCTCAGAGAAGAGTAAATC CTCATCATCCTTCCATCCTGCCCCTGGCAATGCTCAGAGCTCAAGCCAGACCCCCAAAAT CGTGAACTTTGTCTCCGTGGGACCCACATACATGAGGGTCTCTTAGGTGCATGTCCTCTT GTTGCTGAGTCTGCAGATGAGGACTAGGGCTTATCCATGCCTGGGAAATGCCACCTCCTG GAAGGCAGCCAGGCTGGCAGATTTCCAAAAGACTTGAAGAACCATGGTATGAAGGTGATT GGCCCCACTGACGTTGGCCTAACACTGGGCTGCAGAGACTGGACCCCGCCCAGCATTGGG CTGGGCTCGCCACATCCCATGAGAGTAGAGGGCACTGGGTCGCCGTGCCCCACGGCAGGC CCCTGCAGGAAAACTGAGGCCCTTGGGCACCTCGACTTGTGAACGAGTTGTTGGCTGCTC CCTCCACAGCTTCTGCAGCAGACTGTCCCTGTTGTAACTGCCCAAGGCATGTTTTGCCCA CCAGATCATGGCCCACGTGGAGGCCCACCTGCCTCTGTCTCACTGAACTAGAAGCCGAGC CTAGAAACTAACACAGCCATCAAGGGAATGACTTGGGCGGCCTTGGGAAATCGATGAGAA ATTGAACTTCAGGGAGGGTGGTCATTGCCTAGAGGTGCTCATTCATTTAACAGAGCTTCC TTAGGTTGATGCTGGAGGCAGAATCCCGGCTGTCAAGGGGTGTTCAGTTAAGGGGAGCAA CAGAGGACATGAAAAATTGCTATGACTAAAGCAGGGACAATTTGCTGCCAAACACCCATG CCCAGCTGTATGGCTGGGGGCTCCTCGTATGCATGGAACCCCCAGAATAAATATGCTCAG CCACCCTGTGGGCCGGGCAATCCAGACAGCAGGCATAAGGCACCAGTTACCCTGCATGTT GGCCCAGACCTCAGGTGCTAGGGAAGGCGGGAACCTTGGGTTGAGTAATGCTCGTCTGTG TGTTTTAGTTTCATCACCTGTTATCTGTGTTTGCTGAGGAGAGTGGAACAGAAGGGGTGG AGTTTTGTATAAATAAAGTTTCTTTGTCTCTTTA |
Protein Sequence | >3566 : length: 825 MGWLCSGLLFPVSCLVLLQVASSGNMKVLQEPTCVSDYMSISTCEWKMNGPTNCSTELRL LYQLVFLLSEAHTCIPENNGGAGCVCHLLMDDVVSADNYTLDLWAGQQLLWKGSFKPSEH VKPRAPGNLTVHTNVSDTLLLTWSNPYPPDNYLYNHLTYAVNIWSENDPADFRIYNVTYL EPSLRIAASTLKSGISYRARVRAWAQCYNTTWSEWSPSTKWHNSYREPFEQHLLLGVSVS CIVILAVCLLCYVSITKIKKEWWDQIPNPARSRLVAIIIQDAQGSQWEKRSRGQEPAKCP HWKNCLTKLLPCFLEHNMKRDEDPHKAAKEMPFQGSGKSAWCPVEISKTVLWPESISVVR CVELFEAPVECEEEEEVEEEKGSFCASPESSRDDFQEGREGIVARLTESLFLDLLGEENG GFCQQDMGESCLLPPSGSTSAHMPWDEFPSAGPKEAPPWGKEQPLHLEPSPPASPTQSPD NLTCTETPLVIAGNPAYRSFSNSLSQSPCPRELGPDPLLARHLEEVEPEMPCVPQLSEPT TVPQPEPETWEQILRRNVLQHGAAAAPVSAPTSGYQEFVHAVEQGGTQASAVVGLGPPGE AGYKAFSSLLASSAVSPEKCGFGASSGEEGYKPFQDLIPGCPGDPAPVPVPLFTFGLDRE PPRSPQSSHLPSSSPEHLGLEPGEKVEDMPKPPLPQEQATDPLVDSLGSGIVYSALTCHL CGHLKQCHGQEDGGQTPVMASPCCGCCCGDRSSPPTTPLRAPDPSPGGVPLEASLCPASL APSGISEKSKSSSSFHPAPGNAQSSSQTPKIVNFVSVGPTYMRVS |