Cancer metastasis gene database Home
Cancer metastasis database
General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction

Basic Information

Gene ID

28964

Name

GIT1

Synonymous

G protein-coupled receptor kinase interacting ArfGAP 1;GIT1;G protein-coupled receptor kinase interacting ArfGAP 1

Definition

ARF GAP GIT1|ARF GTPase-activating protein GIT1|CAT-1|CAT1|G protein-coupled receptor kinase interactor 1|G protein-coupled receptor kinase-interactor 1|GRK-interacting protein 1|cool-associated and tyrosine-phosphorylated protein 1

Position

17p11.2

Gene Type

protein-coding

COSMIC somatic mutation   [Top]

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.348delT; p.F116fs*72; 17:29582755-29582755

 oesophagus; middle_thirdcarcinoma; squamous_cell_carcinomaDeletion - Frameshift

c.1641G>A; p.V547V; 17:29576102-29576102

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - coding silent

c.1035C>T; p.I345I; 17:29577194-29577194

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.1122G>T; p.Q374H; 17:29576968-29576968

 oesophaguscarcinoma; adenocarcinomaSubstitution - Missense

c.2050G>A; p.E684K; 17:29575102-29575102

 upper_aerodigestive_tract; mouthcarcinomaSubstitution - Missense

c.2050G>A; p.E684K; 17:29575102-29575102

 upper_aerodigestive_tract; mouthcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1346G>T; p.S449I; 17:29576556-29576556

 thyroidother; neoplasmSubstitution - Missense

c.1745G>A; p.R582H; 17:29575819-29575819

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.2067C>T; p.F689F; 17:29575085-29575085

 skinmalignant_melanomaSubstitution - coding silent

c.1714C>T; p.P572S; 17:29575850-29575850

 livercarcinomaSubstitution - Missense

c.1630A>C; p.I544L; 17:29576113-29576113

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1714C>T; p.P572S; 17:29575850-29575850

 livercarcinomaSubstitution - Missense

c.620C>A; p.A207D; 17:29581930-29581930

 thyroidother; neoplasmSubstitution - Missense

c.336G>C; p.Q112H; 17:29582767-29582767

 breastcarcinomaSubstitution - Missense

c.1903C>A; p.L635I; 17:29575394-29575394

 breastcarcinomaSubstitution - Missense

c.1663C>T; p.R555W; 17:29576080-29576080

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1562G>C; p.G521A; 17:29576269-29576269

 oesophaguscarcinoma; adenocarcinomaSubstitution - Missense

c.1562G>C; p.G521A; 17:29576269-29576269

 stomachcarcinoma; intestinal_adenocarcinomaSubstitution - Missense

c.855C>T; p.D285D; 17:29578327-29578327

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.284C>T; p.P95L; 17:29582940-29582940

 skinmalignant_melanomaSubstitution - Missense

c.2244_2245insC; p.K749fs*>14; 17:29574743-29574744

 endometriumcarcinoma; endometrioid_carcinomaInsertion - Frameshift

c.269G>A; p.R90Q; 17:29582955-29582955

 pancreascarcinoma; ductal_carcinomaSubstitution - Missense

c.1934T>C; p.V645A; 17:29575363-29575363

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.1934T>C; p.V645A; 17:29575363-29575363

 large_intestine; coloncarcinomaSubstitution - Missense

c.1934T>C; p.V645A; 17:29575363-29575363

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.1689A>T; p.S563S; 17:29575875-29575875

 lungcarcinoma; adenocarcinomaSubstitution - coding silent

c.1586C>T; p.T529M; 17:29576245-29576245

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.806A>T; p.Q269L; 17:29578735-29578735

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.1464G>A; p.A488A; 17:29576367-29576367

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.1287G>A; p.L429L; 17:29576615-29576615

 urinary_tract; bladdercarcinomaSubstitution - coding silent

c.2142T>C; p.S714S; 17:29574846-29574846

 oesophaguscarcinoma; adenocarcinomaSubstitution - coding silent

c.318C>T; p.F106F; 17:29582785-29582785

 skinmalignant_melanomaSubstitution - coding silent

c.1094A>T; p.D365V; 17:29576996-29576996

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1552C>T; p.P518S; 17:29576279-29576279

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.993G>A; p.K331K; 17:29577236-29577236

 ovarycarcinoma; serous_carcinomaSubstitution - coding silent

c.394G>T; p.D132Y; 17:29582709-29582709

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1859_1860delAA; p.K620fs*49; 17:29575437-29575438

 large_intestine; coloncarcinoma; adenocarcinomaDeletion - Frameshift

c.932C>T; p.A311V; 17:29577694-29577694

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.2150G>A; p.R717Q; 17:29574838-29574838

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1982G>A; p.R661Q; 17:29575315-29575315

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.386C>T; p.T129I; 17:29582717-29582717

 skin; trunkmalignant_melanomaSubstitution - Missense

c.612T>C; p.I204I; 17:29581938-29581938

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.1715C>T; p.P572L; 17:29575849-29575849

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.2119G>A; p.A707T; 17:29574869-29574869

 breastcarcinomaSubstitution - Missense

c.821G>A; p.R274Q; 17:29578361-29578361

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.129C>A; p.R43R; 17:29583540-29583540

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.1902C>G; p.D634E; 17:29575395-29575395

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.618T>G; p.Y206*; 17:29581932-29581932

 thyroidother; neoplasmSubstitution - Nonsense

c.2103A>G; p.S701S; 17:29574885-29574885

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.599G>T; p.G200V; 17:29581951-29581951

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1301C>T; p.A434V; 17:29576601-29576601

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.979C>T; p.Q327*; 17:29577647-29577647

 skinmalignant_melanomaSubstitution - Nonsense

c.1956C>G; p.V652V; 17:29575341-29575341

 livercarcinomaSubstitution - coding silent

c.1956C>G; p.V652V; 17:29575341-29575341

 livercarcinoma; hepatocellular_carcinomaSubstitution - coding silent

c.361C>T; p.P121S; 17:29582742-29582742

 skinmalignant_melanomaSubstitution - Missense

c.719-4T>A; p.?; 17:29581384-29581384

 livercarcinomaUnknown

c.1226G>A; p.R409Q; 17:29576864-29576864

 upper_aerodigestive_tract; mouthcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1226G>A; p.R409Q; 17:29576864-29576864

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.640G>A; p.E214K; 17:29581820-29581820

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.265G>A; p.G89S; 17:29582959-29582959

 oesophagus; lower_thirdcarcinoma; adenocarcinomaSubstitution - Missense

c.561A>T; p.V187V; 17:29581989-29581989

 bone; fibulaEwings_sarcoma-peripheral_primitive_neuroectodermal_tumourSubstitution - coding silent

c.1220G>A; p.R407Q; 17:29576870-29576870

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.237C>T; p.S79S; 17:29582987-29582987

 thyroidcarcinomaSubstitution - coding silent

c.775G>A; p.E259K; 17:29578766-29578766

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1792T>C; p.Y598H; 17:29575664-29575664

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.877G>T; p.D293Y; 17:29578305-29578305

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1885G>T; p.E629*; 17:29575412-29575412

 central_nervous_system; occipital_lobeglioma; astrocytoma_Grade_IVSubstitution - Nonsense

c.1981C>T; p.R661W; 17:29575316-29575316

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1511G>A; p.R504H; 17:29576320-29576320

 autonomic_ganglianeuroblastomaSubstitution - Missense

c.380G>A; p.G127E; 17:29582723-29582723

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.2165C>A; p.P722Q; 17:29574823-29574823

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.2233G>A; p.A745T; 17:29574755-29574755

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.357G>A; p.K119K; 17:29582746-29582746

 kidneyother; neoplasmSubstitution - coding silent

c.1822C>G; p.L608V; 17:29575634-29575634

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.493G>A; p.E165K; 17:29582057-29582057

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.403A>T; p.K135*; 17:29582700-29582700

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Nonsense

c.1381-1G>C; p.?; 17:29576451-29576451

 lungcarcinoma; adenocarcinomaUnknown

c.1627G>A; p.A543T; 17:29576116-29576116

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.1856G>A; p.G619D; 17:29575441-29575441

 central_nervous_system; thalamusglioma; oligodendroglioma_Grade_IIISubstitution - Missense

c.850T>C; p.Y284H; 17:29578332-29578332

 stomachadenocarcinomaSubstitution - Missense

c.1981C>A; p.R661R; 17:29575316-29575316

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - coding silent

c.1183G>T; p.E395*; 17:29576907-29576907

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Nonsense

c.2286A>G; p.*762W; 17:29574702-29574702

 stomachcarcinoma; adenocarcinomaNonstop extension

c.933C>T; p.A311A; 17:29577693-29577693

 livercarcinoma; hepatocellular_carcinomaSubstitution - coding silent

c.1510C>T; p.R504C; 17:29576321-29576321

 skinmalignant_melanomaSubstitution - Missense

c.1180C>G; p.Q394E; 17:29576910-29576910

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1846C>T; p.L616L; 17:29575451-29575451

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.791C>A; p.A264D; 17:29578750-29578750

 stomachcarcinoma; intestinal_adenocarcinomaSubstitution - Missense

c.849G>A; p.V283V; 17:29578333-29578333

 pancreascarcinomaSubstitution - coding silent

c.90G>T; p.V30V; 17:29583579-29583579

 lungcarcinoma; adenocarcinomaSubstitution - coding silent

c.1699T>C; p.F567L; 17:29575865-29575865

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.404A>G; p.K135R; 17:29582699-29582699

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.1694T>C; p.V565A; 17:29575870-29575870

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.876T>A; p.N292K; 17:29578306-29578306

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.2232C>T; p.I744I; 17:29574756-29574756

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.1353C>T; p.S451S; 17:29576549-29576549

 breastcarcinomaSubstitution - coding silent

c.1975C>A; p.L659M; 17:29575322-29575322

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1353C>T; p.S451S; 17:29576549-29576549

 oesophagus; lower_thirdcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.1285C>T; p.L429L; 17:29576617-29576617

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent