| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 5742 |
Name | PTGS1 |
Synonym | COX1|COX3|PCOX1|PES-1|PGG/HS|PGHS-1|PGHS1|PHS1|PTGHS;prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase);PTGS1;prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) |
Definition | PGH synthase 1|cyclooxygenase-1|prostaglandin G/H synthase 1|prostaglandin H2 synthase 1 |
Position | 9q32-q33.3 |
Gene Type | protein-coding |
Pathways and Diseases | |
Pathway | basic mechanism of action of ppara pparb(d) and pparg and effects on gene expression;PID BioCarta;100064 |
Pathway | Metabolic pathways;KEGG PATHWAY;hsa01100 |
Pathway | aspirin blocks signaling pathway involved in platelet activation;PID BioCarta;100030 |
Pathway | Biological oxidations;Reactome;REACT:13433 |
Pathway | mechanism of acetaminophen activity and toxicity;PID BioCarta;100256 |
Pathway | Metabolism of lipids and lipoproteins;Reactome;REACT:22258 |
Pathway | prostanoid biosynthesis;BioCyc;PWY66-374 |
Pathway | Hormone biosynthesis;Reactome;REACT:15314 |
Pathway | Arachidonic acid metabolism;KEGG PATHWAY;hsa00590 |
Disease | Hypertension/complications*;GAD |
Disease | colon polyps;GAD |
Disease | Cardiovascular Diseases;GAD |
Disease | CARDIOVASCULAR;GAD |
Disease | CANCER;GAD |
Disease | colorectal cancer;GAD |
External Links | |
Links to Entrez Gene | 5742 |
Links to all GeneRIF Items | 5742 |
Links to iHOP | 5742 |
Sequence Information | |
Nucleotide Sequence | >5742 : length: 9087 CTCATCTAGGAAACCATCAGCAGGCCAGGCTGGACTGCCCCATTTCTAGCCCCCTTTCTT CTCTGCAGACTGCCCTGTTTCTAGCCCCTTTTCTTCTCTACCCTTTTCTGTAGAGTGCGT TAGACCCATTTTACAGAAGGGGACTCTGAGACCCTTTCTTCTCTGCGGGGCAGGGTATGT GGTTCAGACGAGCCGCTTCCATCCCCAGTTCTGTCCCTAAGCCCTGGGTGACCTCAGCAT TGAGCATCGTCTCTGAGCCTCAGTTTCCTGTCTATATCTAGTGCCACCAGGCATCAGAAA CGGAGTCTCTTGCTCTGGTTCTTGCTGTTCCTGCTCCTGCTCCCGCCGCTCCCCGTCCTG CTCGCGGACCCAGGGGCGCCCACGCCAGGGGCCTCTTTGGGAGGAAGCCGCAGGCACCAA GGGAAATGAGTTCCCTTTCTCCAGCCTCTAACCGTCTGGGAACCCATCCTGATTCCCATT GCCAGTGGAGAAGGTCTCCCCTGGTGAAGACTTCGGGAGAACATGGGAGATGGAAATACA TTTAGGAGCCGGGATGCTTCATCTGGGGTTTAAGAGATCCCCATTGAGCAAATGAGGAAA CCGAGGCTCAGTAGGTGCCATGATTCCCCAAGCTCACAAAATACATGGTGGGCCCAGGAT CTGAACTCAGGTCTGTCTGCGTCCACACACTTCGCAAGGTCTTTCCACAGAAAGCTGCTT CTACCCACAATGGACCCGGAGCCACTCTGGGTTTCATGGGGGAGGTTGATGGGGAAATTC CGCCCTTCCCTCCCCCATGCATGTGCCAGGTTCCAGGTGAAGGAATTCAGCTCCTCGCTC AGCCAACCTTCCTCCCCCAGCTCGCTGCTTGTGTGTGTGCGTGTGTGTGAGCATGTGTCC CAGTTGGATATAGTTTCCTCCACCACCTAGCTGTGTAAAATCTCTAAAATGAGGCCCAGA GAGGGCAGGAGGGAGCAGAGGGAGTCCGCACTTTCTGCTGTGATGCTCTAAGGATCTGGT GCGTGGGGGAAAGAGGAAAGATATGTACATGGATTTTGGATCAGACCAAGTTTCCTGAAA CGGGCTTTGGGTGGGTGGCATTTAGGGGACCCAAAGAGAGGACGGAGGGTGCTCTAGGAA AGGGATTGCGTTGAATAAAAGTCTGGTTTATGGGAAGAGGAGGAGGAAGACTCATGTGGC CAGCACTTTAAAGTTTACAAAGGTTGGTTGTGGACATCCACCTCTTTGGTGCTCTCAACA GCCCTGCCAGAGAGATGCGTTAGACCCAGTCTACAGAAGGGGACTCTGAGGCCCAGAGGG AGTGAAGCCACTTGTCTGAATCCTCACAGTGAGCTGGTGGTGGGGAGTAGAAGGGGCTCT TCAGGTTGCCTCGCTGACCCATCTTGTCAGTCCCTGGATCAGCCCAGCACTTCCTCTGAG GCCCCATCTGGCCTCATCCAGGCACTCTTGGTATACAGGTCCCACCCGTCTGTATTCTTT TTTAGTCCATTCACTAATGCACAATGAGCCATGGTCTGTGCTATTTTGTTTTTTGCCTTT TCTGTTTCCTTTTGTATAATAAATGTTTACACGGAATTGTTTTTTTTTATCCCCAAGGGT TATTTATGCCAGTCTTTGGCTGGGGCCTGGAGACACGGAGCTGGGAGGAGCTGACAGGCT GATGGTGGAGCCAGAAATGCCAACAGACTGTCATCCAAGGGGACCAGGGCTGTGCGGAGC TCATGGGAGGAAGCAGGGGTATAGGGAGCCCAGGGAAGGGAGCAGGGGTGTGCGGAGCTC AGGGGAGGGAGCAGCTGCCTCTCAGTGCGAAGAATTGAGGGAGGCTTCTTGGATCTGATG ACTTTTGGACTGGACCTCGAAGGAGGTGGCGGGTGGGGGAAACACTAAGAGACTCGACCA GGAAACACCGTAAGGGTAATGTGGAGCAGGAGGCTGAGGTTGGATGCGTAATGTGGGGAT GAGACTGGAGGCCAGAAAACTGGTACCGAGGCTCCTGCAAGGATCTAGGAAAGAACGAAT GACTGGTGGAGTGCAGGGGCAGAAGGTCTGGGTTGCCCTCATATTTCCAAGTCTGCGAGT AAACTGAGGGCCAAGCTACTTGGGCATCTGCCCCAGGAAGCCAAAGCCTGTCTTTTACCT CTAGAGGCAAAGGAGATGAAGAGATGAGGGCTGCACTCACCTAAGAGGGCAGGCGGAGGG AGAGAATGCTGCTTTTGCCTCTCTGGTGGGTGAGGAGATGGAGGCCAGCCTGGAGGCAAG GCTGTGCCGGGGGCGCCCTGAATGCTCAAGTACTTCCCCTCTAGTCTCTGGACTTGACTC AGTGCCCATCTTCTAGATGGGGATAGGGCATGACCTGGCAACCAGAGCTGCATGCCAGGC AGAGGAGCCCCAGGCCAGCTGACCCGGGCACATGGGGCAAGATGCCAGCTGTGCCAAGGC TGCCCGGGTGCCTGCACCTGCTCTCGCCAGCACCAGTTGGGTCTGTGGGCCGGGAGAGGG CTTCCCCACCAGCAGGCTCTTCCAGCTGCTGGGCCCAGTTGTCTGGATCTGGTGTGGTGG TGCTTAGGTGTGGGGACTGGGGCCCAGGCCAAACCAGTCAGGGTTCCCCACCTTTTTTTT TTTTCTCTCTGGCTGCCAGGTCCCCAGAGACTCTCTAAATATTACTCTTTAGGGGATTTG GGTCCTGCCTCTTCACTGGGCAATCTTGCAGCCTGACACCTCTGCATCCTGGAGGACTTG GTGTTCCCTGGCTGTGCCTGTCCCCTAGTCACGCTCAGTCCTGGACCTGGAGCCCTGACT TTTGGGCTAGGGGGTGTTCCTTGCCCAAACCCTTGGAAAGGTCCTGGAACCAGGCAGTTC TGGACAGTCCTCATCTGTGGGGATGGGGACTAGCAGCTTGGCCTTTGGGCTGCGTGTGTC TGGCATGCAGCGTGGTGTGCTGATCATCTCTGCCTCCGCGTGTCTTGGGGACTCAGTGAG AGCAAATGGGAAGGTTCTCTGCTGATGGGGCAGTTGTGGGAGGGTTGTATTGATACAAAT AATGGAGAGGGACAGATTGGCTCTACCCAGAGTAGAGGGCCTGGACGTCGAAAGGAAGGC CTCCTTTAGCCCGCCTGCTAAACCCCCTTCATGGGATATACAGAAAAATGAGGCTCCAGA GGTGGGAGGGACTCACCCAAGAATGCACAGCCAGTAAGAGCAGCCACTCTCTAATACAGC TCTCCCAAGCAACTACTTGGTGCCTGGCCCTGTGCTGAGTATGGGGGACTCAAAGTGAAT TAGACTTGGTACCTGCATCTCCTTGGTTTTCTTTCTTGATGAACAGGGGTGTCCTCCACT GAGCATAGAACTGAGTTGGCATGAAAACATGCAGGATTGAAGTTAGACCGAAGGAAGGCC TTCCTGTACGAATACTTCCTAAAGATCTGGTTGTGGCAGGAGATGGTGATCCCCCTGGGG TCCTGGTTTCATTCGTTCTGGATTTTCAAGGTTCACTTTGAAGGAATGTGACAAATCCAA CTCAACTGGGTCATCCTCAGTCTGCATCAAAGCGACTCTCCCTTTCCATCCCTTCCCCAA ATCCAGTCCTGGGTACCTCCAGGAGTAGGAGGAGGAGGGAGATTAAGTCTTGGCTCCGCA ACTTCAAAGCAGTGGGGTCTGGGCAAGCCTCCTGCTTTCTCTGGGCCCTACATTCCTCAT TATGCAATGGGGAGTCTCACCTACCTCTCTTAGGGAGTGCTGGGGAGATAAATGAGCGTG GGTGTGGAAGGTTGTGGACTTGGTCGGCTGGAGCCCTGGCTTTCTGGCTGGGCTGTGATG GTCAGGCTGTAGTCTAGTGGCACCCAGTCTCCTCTCCGCCCACCCTGACACCTTGGGGCA CCAGCGGCAGGCCCACTGTTGTCCTTCCTGGGAGAACTTTTCCTGCCCCAGAGCAGTGGT GTTTATGGAAAGAACGTGGCGGGGGAGGCGGGAGGGGGGAAGCTGGATGGGCCGGACTGG GAGGGAGGAGCCTCAGCTCCCGCACAGCCTCTCTTGGCAGGGAGGGTGTGGGCAGCCGTT CCAGCTTCAGCGTCTGGAGCTTGTGGCTCTTCTGCCTGCCGAGGCAGAGCTCTAGGGCCA TGGCGGGAGGCCTTCCGGCTCCACCTCAGACAGCTGTTGAGGGCCTGGAAGATGAGGGAC TCCTTTTGGTCAGGCTGGAGTGAATCCCTGTTGTTACTATCCATGCCAGCACCAGGGCAT CTGTGTCCGCTTCGGCCTTGACCGCTACCAGTGTGACTGCACCCGCACGGGCTATTCCGG CCCCAACTGCACCATCCCTGGCCTGTGGACCTGGCTCCGGAATTCACTGCGGCCCAGCCC CTCTTTCACCCACTTCCTGCTCACTCACGGGCGCTGGTTCTGGGAGTTTGTCAATGCCAC CTTCATCCGAGAGATGCTCATGCGCCTGGTACTCACAGTGCGCTCCAACCTTATCCCCAG TCCCCCCACCTACAACTCAGCACATGACTACATCAGCTGGGAGTCTTTCTCCAACGTGAG CTATTACACTCGTATTCTGCCCTCTGTGCCTAAAGATTGCCCCACACCCATGGGAACCAA AGGGAAGAAGCAGTTGCCAGATGCCCAGCTCCTGGCCCGCCGCTTCCTGCTCAGGAGGAA GTTCATACCTGACCCCCAAGGCACCAACCTCATGTTTGCCTTCTTTGCACAACACTTCAC CCACCAGTTCTTCAAAACTTCTGGCAAGATGGGTCCTGGCTTCACCAAGGCCTTGGGCCA TGGGGTAGACCTCGGCCACATTTATGGAGACAATCTGGAGCGTCAGTATCAACTGCGGCT CTTTAAGGATGGGAAACTCAAGTACCAGGTGCTGGATGGAGAAATGTACCCGCCCTCGGT AGAAGAGGCGCCTGTGTTGATGCACTACCCCCGAGGCATCCCGCCCCAGAGCCAGATGGC TGTGGGCCAGGAGGTGTTTGGGCTGCTTCCTGGGCTCATGCTGTATGCCACGCTCTGGCT ACGTGAGCACAACCGTGTGTGTGACCTGCTGAAGGCTGAGCACCCCACCTGGGGCGATGA GCAGCTTTTCCAGACGACCCGCCTCATCCTCATAGGGGAGACCATCAAGATTGTCATCGA GGAGTACGTGCAGCAGCTGAGTGGCTATTTCCTGCAGCTGAAATTTGACCCAGAGCTGCT GTTCGGTGTCCAGTTCCAATACCGCAACCGCATTGCCATGGAGTTCAACCATCTCTACCA CTGGCACCCCCTCATGCCTGACTCCTTCAAGGTGGGCTCCCAGGAGTACAGCTACGAGCA GTTCTTGTTCAACACCTCCATGTTGGTGGACTATGGGGTTGAGGCCCTGGTGGATGCCTT CTCTCGCCAGATTGCTGGCCGGATCGGTGGGGGCAGGAACATGGACCACCACATCCTGCA TGTGGCTGTGGATGTCATCAGGGAGTCTCGGGAGATGCGGCTGCAGCCCTTCAATGAGTA CCGCAAGAGGTTTGGCATGAAACCCTACACCTCCTTCCAGGAGCTCGTAGGAGAGAAGGA GATGGCAGCAGAGTTGGAGGAATTGTATGGAGACATTGATGCGTTGGAGTTCTACCCTGG ACTGCTTCTTGAAAAGTGCCATCCAAACTCTATCTTTGGGGAGAGTATGATAGAGATTGG GGCTCCCTTTTCCCTCAAGGGTCTCCTAGGGAATCCCATCTGTTCTCCGGAGTACTGGAA GCCGAGCACATTTGGCGGCGAGGTGGGCTTTAACATTGTCAAGACGGCCACACTGAAGAA GCTGGTCTGCCTCAACACCAAGACCTGTCCCTACGTTTCCTTCCGTGTGCCGGATGCCAG TCAGGATGATGGGCCTGCTGTGGAGCGACCATCCACAGAGCTCTGAGGGGCAGGAAAGCA GCATTCTGGAGGGGAGAGCTTTGTGCTTGTCATTCCAGAGTGCTGAGGCCAGGGCTGATG GTCTTAAATGCTCATTTTCTGGTTTGGCATGGTGAGTGTTGGGGTTGACATTTAGAACTT TAAGTCTCACCCATTATCTGGAATATTGTGATTCTGTTTATTCTTCCAGAATGCTGAACT CCTTGTTAGCCCTTCAGATTGTTAGGAGTGGTTCTCATTTGGTCTGCCAGAATACTGGGT TCTTAGTTGACAACCTAGAATGTCAGATTTCTGGTTGATTTGTAACACAGTCATTCTAGG ATGTGGAGCTACTGATGAAATCTGCTAGAAAGTTAGGGGGTTCTTATTTTGCATTCCAGA ATCTTGACTTTCTGATTGGTGATTCAAAGTGTTGTGTTCCTGGCTGATGATCCAGAACAG TGGCTCGTATCCCAAATCTGTCAGCATCTGGCTGTCTAGAATGTGGATTTGATTCATTTT CCTGTTCAGTGAGATATCATAGAGACGGAGATCCTAAGGTCCAACAAGAATGCATTCCCT GAATCTGTGCCTGCACTGAGAGGGCAAGGAAGTGGGGTGTTCTTCTTGGGACCCCCACTA AGACCCTGGTCTGAGGATGTAGAGAGAACAGGTGGGCTGTATTCACGCCATTGGTTGGAA GCTACCAGAGCTCTATCCCCATCCAGGTCTTGACTCATGGCAGCTGTTTCTCATGAAGCT AATAAAATTCGCTTTCTAAAGTTACCTGTTATATATCTCTTTTGGTCCCATCCTCTAAAG CAGAGGCAACACTGGAACATGGCTAGCCTTTCTTGTAGCCATGGCTGGGCGTGCTAGAGG TTGCAGCATGAGACTTTCTGCTGGGATCCTTGGGCCCATCACTGTATAGACATGCTACCA CTGGTACTTCCTTTCTCCCTGCGGGCCAGGCACTGCCCTTTTCAGGAAGCTCTCTTAAAA TACCCATTGCCCCAGACCTGGAAGATATAACATTCAGTTCCCACCATCTGATTAAAACAA CTTCCTCCCTTACAGAGCATACAACAGAGGGGGCACCCGGGGAGGAGAGCACATACTGTG TTCCAATTTCACGCTTTTAATTCTCATTTGTTCTCACACCAACAGTGTGAAGTGCGTGGT ATAATCTCCATTTCAAAACCAAGGAAGCAGCCTCAGAGTGGTCGAGTGACACACCTCACG CAGGCTGAGTCCAGAGCTTGTGCTCCTCTTGATTCCTGGTTTGACTCAGTTCCAGGCCTG ATCTTGCCTGTCTGGCTCAGGGTCAAAGACAGAATGGTGGAGTGTAGCCTCCACCTGATA TTCAGGCTACTCATTCAGTCCCAAATATGTATTTTCCTAAGTGTTTACTATGTGCCAGTT CCTGTAACAGGTGTGGGGACACAGCAGTGAGTAATCAATACAGACAAGGTTCTGCCCTTA TGGAGCTCACACTCCAGTGGCAGACAAACAGACCATAAATAAGGAAACGATGAAATAAGA TATATACAAGGTGAGTGTGACTTCCCTTCTAACCCCCTCTGCTCTGTCCTCCCCTATTGC GCTCTCAAGACCAGAGACCCAACAGCAGTGATCTCAGGGCAGACAGCCCTCCACTCCAGC TCTGAGACCCTTTTCTCAGGACCTCTGTAGGCAGCAGAGAGAGAGGACAGAGGGGTAAGA TGAGGGGTTGAGGGAAGGTTCTTCATGATCCACACTTTGGGCTTAGTATTTCTCAGGAAG AGCTATGGCCCAGAAACAACAGGGGAAACTAGAGTTCGGTCTGACAGTCCTTGGGGTTAA GTCTCCTGTCTTATGGTCCAGAAACTCCTGTTTCTCCTTAGTTGGCTGGAAACTGCTCCC ATCATTCCTTCTGGCCTCTGCTGAATGCAGGGAATGCAATCCTTCCCTGCTCTTGCAGTT GCTCTGACGTAGAAAGATCCTTCGGGTGCTGGAAGTCTCCATGAAGAGCTTGTGTCCTGT CCTTTCTTGCAGATTCTATTTCCCCTCTTCTGCTAATACCTCTTACTTTGCTTGAGAATC CTCTCCTTTCTTATTAATTTCAGTCTTGGTGGTTCTATCAGGGGTGCATTCTGGCCAAGG GGTGGGCCTGTGAATCAATCCTGGGCAATCAGACACCCTCTCCTTAAAAACTGGCCCGTG GAGACTGAGATCACTGACTCTGACTCATCCCCACAGCTGGCTCTGACAAGATGGTCCATT TGTTCCTGCTTCCGAGATCCCCAGGGCAGCCTGGATCCCTGCCCTTCTCAAGACTTTAGC TTTTCCTTCCATCCGGTGGCCTATTCCAGGAATTCCTCTTTTGCTTAAATCAGTTGGAGT TTGTGTCTGTTGCTTGTAATCAAGCCTTTATGGCTGCTGGGCTGAGTGACACAAGCACTT TAATGGCCTGGAGGGACTTTTAATCAGTGAAGATGCAATCAGACAAGTGTTTTGGAAAGA GCACCCTCGAGAAGGGTGGATGACAGGGCAGAGCAGGAAGGACAGGAAGCTGGCAGAACG GAGGAGGCTGCAGCCGTGGTCCAACCAGGAGCTGATGGCAGCTGGGGCTAGGGGAAGGGC TTTGAGGGTGGAAGGATGGGATGGGTTCCAGAGGTATTCCTCTCTTAAATGCAAGTGCCT AGATTAGGTAGACTTTGCTTAGTATTGACAACTGCACATGAAAGTTTTGCAAAGGGAAAC AGGCTAAATGCACCAAGAAAGCTTCTTCAGAGTGAAGAATCTTAATGCTTGTAATTTAAA CATTTGTTCCTGGAGTTTTGATTTGGTGGATGTGATGGTTGGTTTTATTTGTCAGTTTGG TTGGGCTATAGCACACAGTTATTTAATCAAACAGTAATCTAGGTGTGGCTGTGAAGGTAT TTTGTAGATGTGATTAACATCTACAATCAGTTGACTTTAAGTGAAAGAGATTACTTAAAT AATTTGGGTGAGCTGCACCTGATTAGTTGAAAGGCCTCAAGAACAAACACTGCAGTTTCC TGGAAAAGAAGAAACTTTGCCTCAAGACTATAGCCATCGACTCCTGCCTGAGTTTCCAGC CTGCTAGTCTGCCCTATGGATTTGAAGTTTGCCAACCCCAACAATTGTGTGAATTAATTT CTAAAAATAAAGCTATATACAGCCATC |
Protein Sequence | >5742 : length: 599 MSRSLLLWFLLFLLLLPPLPVLLADPGAPTPVNPCCYYPCQHQGICVRFGLDRYQCDCTR TGYSGPNCTIPGLWTWLRNSLRPSPSFTHFLLTHGRWFWEFVNATFIREMLMRLVLTVRS NLIPSPPTYNSAHDYISWESFSNVSYYTRILPSVPKDCPTPMGTKGKKQLPDAQLLARRF LLRRKFIPDPQGTNLMFAFFAQHFTHQFFKTSGKMGPGFTKALGHGVDLGHIYGDNLERQ YQLRLFKDGKLKYQVLDGEMYPPSVEEAPVLMHYPRGIPPQSQMAVGQEVFGLLPGLMLY ATLWLREHNRVCDLLKAEHPTWGDEQLFQTTRLILIGETIKIVIEEYVQQLSGYFLQLKF DPELLFGVQFQYRNRIAMEFNHLYHWHPLMPDSFKVGSQEYSYEQFLFNTSMLVDYGVEA LVDAFSRQIAGRIGGGRNMDHHILHVAVDVIRESREMRLQPFNEYRKRFGMKPYTSFQEL VGEKEMAAELEELYGDIDALEFYPGLLLEKCHPNSIFGESMIEIGAPFSLKGLLGNPICS PEYWKPSTFGGEVGFNIVKTATLKKLVCLNTKTCPYVSFRVPDASQDDGPAVERPSTEL |