| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 5330 |
Name | PLCB2 |
Synonym | PLC-beta-2;phospholipase C, beta 2;PLCB2;phospholipase C, beta 2 |
Definition | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2|phosphoinositide phospholipase C-beta-2 |
Position | 15q15 |
Gene Type | protein-coding |
Pathways and Diseases | |
Pathway | Vascular smooth muscle contraction;KEGG PATHWAY;hsa04270 |
Pathway | Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway;PANTHER;P00027 |
Pathway | Phosphatidylinositol signaling system;KEGG PATHWAY;hsa04070 |
Pathway | Signaling by GPCR;Reactome;REACT:14797 |
Pathway | Alpha-synuclein signaling;PID Curated;200187 |
Pathway | 5HT2 type receptor mediated signaling pathway;PANTHER;P04374 |
Pathway | Alzheimer's disease;KEGG PATHWAY;hsa05010 |
Pathway | Thyrotropin-releasing hormone receptor signaling pathway;PANTHER;P04394 |
Pathway | Salivary secretion;KEGG PATHWAY;hsa04970 |
Pathway | Huntington's disease;KEGG PATHWAY;hsa05016 |
Pathway | Wnt signaling pathway;KEGG PATHWAY;hsa04310 |
Pathway | Amoebiasis;KEGG PATHWAY;hsa05146 |
Pathway | Melanogenesis;KEGG PATHWAY;hsa04916 |
Pathway | Opioid Signalling;Reactome;REACT:15295 |
Pathway | S1P1 pathway;PID Curated;200071 |
Pathway | 2-arachidonoylglycerol biosynthesis;PANTHER;P05726 |
Pathway | Endothelin signaling pathway;PANTHER;P00019 |
Pathway | Alpha adrenergic receptor signaling pathway;PANTHER;P00002 |
Pathway | Carbohydrate digestion and absorption;KEGG PATHWAY;hsa04973 |
Pathway | Diabetes pathways;Reactome;REACT:15380 |
Pathway | Inflammation mediated by chemokine and cytokine signaling pathway;PANTHER;P00031 |
Pathway | Endogenous cannabinoid signaling;PANTHER;P05730 |
Pathway | D-myo-inositol (1,4,5)-trisphosphate biosynthesis;BioCyc;PWY-6351 |
Pathway | Taste transduction;KEGG PATHWAY;hsa04742 |
Pathway | D-myo-inositol-5-phosphate metabolism;BioCyc;PWY-6367 |
Pathway | Histamine H1 receptor mediated signaling pathway;PANTHER;P04385 |
Pathway | Long-term potentiation;KEGG PATHWAY;hsa04720 |
Pathway | Wnt signaling pathway;PANTHER;P00057 |
Pathway | Inositol phosphate metabolism;KEGG PATHWAY;hsa00562 |
Pathway | Thromboxane A2 receptor signaling;PID Curated;200069 |
Pathway | Synaptic Transmission;Reactome;REACT:13685 |
Pathway | Calcium signaling pathway;KEGG PATHWAY;hsa04020 |
Pathway | GnRH signaling pathway;KEGG PATHWAY;hsa04912 |
Pathway | Chagas disease;KEGG PATHWAY;hsa05142 |
Pathway | Pancreatic secretion;KEGG PATHWAY;hsa04972 |
Pathway | Gap junction;KEGG PATHWAY;hsa04540 |
Pathway | Oxytocin receptor mediated signaling pathway;PANTHER;P04391 |
Pathway | Integration of energy metabolism;Reactome;REACT:1505 |
Pathway | phospholipases;BioCyc;LIPASYN-PWY |
Pathway | Metabolic pathways;KEGG PATHWAY;hsa01100 |
Pathway | Chemokine signaling pathway;KEGG PATHWAY;hsa04062 |
Pathway | Long-term depression;KEGG PATHWAY;hsa04730 |
Pathway | RAC1 signaling pathway;PID Curated;200190 |
Pathway | Gastric acid secretion;KEGG PATHWAY;hsa04971 |
Disease | Cancer;FunDO |
Disease | Platelet PLC beta-2 deficiency;OMIM |
External Links | |
Links to Entrez Gene | 5330 |
Links to all GeneRIF Items | 5330 |
Links to iHOP | 5330 |
Sequence Information | |
Nucleotide Sequence | >5330 : length: 4778 AGCCTCCTTGGGCAGAAGCAGTGACCACAGGCCCCCATGGCAGGCAGGGCGGGTGGGAGG AGGGTGATTTACAAGGCAGATGGGCCTCTGGCTACAGCTCAGTCCTGCACTCAGCCAGGG CCACCCCAGGGGCTATAAGAGCAACTAGATTTCTGGAGCAGCTCGGGGATGGGTGCCATT TGAGCCCAGCTTGGCTCCCCCTCCTGGCTGGCCTCCTTCCTGCCCTTCTGCCTGCCTGTG TCTGCTGAGATTCTGCAAAGAGGAACGCTTGGCACCATGTCTCTGCTCAACCCTGTCCTG CTGCCCCCCAAGGTGAAGGCCTATCTGAGCCAAGGGGAGCGCTTCATCAAATGGGATGAT GAAACTACAGTTGCCTCTCCAGTTATCCTCCGTGTGGATCCTAAGGGCTACTACTTATAC TGGACGTATCAAAGTAAGGAGATGGAGTTTCTGGATATCACCAGCATCCGGGATACTCGC TTTGGGAAGTTTGCCAAGATGCCCAAGAGCCAGAAGCTCCGGGACGTCTTCAACATGGAC TTTCCTGATAACAGTTTCCTGCTGAAGACACTCACGGTGGTGTCCGGCCCGGACATGGTG GACCTCACCTTCCACAACTTCGTCTCCTACAAGGAGAACGTGGGCAAGGCCTGGGCTGAG GACGTACTGGCCCTAGTCAAACATCCGCTGACGGCCAACGCCTCCCGCAGCACCTTCCTG GACAAGATCCTTGTGAAGCTCAAGATGCAGCTCAACTCTGAAGGGAAGATTCCGGTGAAG AACTTTTTCCAGATGTTTCCTGCTGACCGCAAGCGGGTGGAAGCTGCTCTCAGTGCCTGC CACCTCCCCAAAGGCAAAAATGACGCCATCAATCCTGAGGACTTCCCAGAACCTGTCTAC AAGAGTTTCCTCATGAGCCTCTGTCCTCGGCCAGAAATAGATGAGATCTTCACTTCTTAC CATGCTAAGGCCAAACCCTACATGACGAAGGAGCACCTGACCAAATTCATCAACCAGAAA CAGCGGGACTCCCGGCTTAACTCCCTGCTGTTCCCGCCAGCACGGCCTGACCAGGTGCAG GGCCTCATCGACAAGTATGAGCCCAGTGGCATCAATGCACAGAGGGGCCAGCTGTCACCT GAAGGCATGGTCTGGTTTCTCTGTGGGCCAGAGAACAGCGTGCTGGCCCAGGACAAGCTG CTGCTCCACCACGACATGACGCAGCCACTCAATCATTACTTCATCAACTCGTCCCACAAC ACCTACCTGACAGCCGGCCAGTTCTCAGGCCTCTCCTCGGCTGAGATGTACCGCCAGGTG CTGCTCTCTGGCTGCCGTTGCGTGGAGCTAGACTGCTGGAAGGGGAAACCCCCTGACGAG GAGCCCATTATCACCCATGGCTTCACCATGACCACAGACATCTTCTTCAAAGAAGCAATT GAGGCTATTGCAGAAAGCGCCTTTAAGACCTCCCCCTATCCCATCATCCTGTCGTTTGAG AACCATGTGGACTCACCCCGCCAGCAGGCTAAGATGGCTGAGTATTGCCGGACGATCTTT GGGGATATGCTGCTCACAGAGCCCCTGGAAAAGTTCCCACTAAAACCAGGTGTCCCCCTG CCCAGCCCTGAGGATCTCAGGGGCAAGATCCTCATCAAGAACAAGAAGAACCAGTTTTCT GGCCCCACCTCCTCCAGTAAGGATACTGGTGGGGAGGCTGAGGGCAGCAGCCCACCCAGT GCCCCTGCAGGTGAGGGCACAGTGTGGGCTGGCGAGGAAGGGACTGAGCTGGAGGAGGAG GAGGTGGAAGAGGAAGAGGAGGAGGAGTCAGGAAACCTGGATGAAGAAGAGATTAAGAAG ATGCAGTCGGATGAGGGCACAGCGGGCCTGGAAGTGACGGCTTATGAGGAGATGTCCAGC CTAGTCAATTACATCCAGCCCACCAAGTTCGTCTCCTTTGAGTTCTCTGCCCAAAAGAAC CGAAGTTATGTCATCTCGTCCTTCACAGAGCTCAAGGCATATGACCTGCTCTCCAAGGCC TCGGTGCAGTTTGTGGACTACAACAAGCGCCAGATGAGCCGCATTTACCCCAAGGGAACC CGCATGGACTCCTCCAACTACATGCCCCAGATGTTCTGGAATGCTGGATGCCAGATGGTT GCCCTCAACTTCCAGACGATGGACTTGCCCATGCAGCAGAACATGGCAGTATTTGAGTTC AACGGGCAGAGCGGCTACCTCCTCAAGCATGAGTTCATGCGCCGGCCGGACAAGCAGTTC AACCCCTTCTCAGTGGACCGCATCGACGTGGTGGTGGCCACCACCCTTTCCATTACGGTG ATCTCTGGGCAGTTCCTGTCAGAACGCAGCGTGCGCACCTATGTAGAAGTGGAGCTGTTT GGCCTTCCTGGGGACCCCAAGAGGCGCTATCGAACTAAGCTGTCACCCAGTACTAACTCC ATCAATCCTGTCTGGAAGGAGGAGCCCTTTGTCTTTGAGAAGATCTTGATGCCTGAGCTG GCCTCCCTCAGAGTGGCTGTGATGGAGGAAGGCAACAAGTTTCTTGGACACCGCATCATC CCCATCAATGCCCTAAATTCTGGGTACCACCACCTGTGCCTGCACAGTGAGAGCAACATG CCCCTCACCATGCCTGCGCTCTTCATCTTCCTGGAGATGAAGGACTACATACCTGGTGCT TGGGCAGATCTCACTGTGGCCCTCGCCAACCCCATTAAGTTCTTCAGTGCCCATGACACG AAGTCTGTGAAGCTCAAGGAGGCCATGGGAGGTCTGCCTGAGGTCTGTGTTGCCTGCACT GCTGCCAGGGGCTCACCAGAGATTAGCCCTATTTATGGGAGAGGCTGGGGAGAGGGCCGA GTCCCAGGCTCGGGGAGAGAGGGCTGTCAAGCCACCTTCCTGACCTGCTCTCCCTACACA GAAGCCCTTCCCACTGGCGAGTCCAGTTGCCAGCCAGGTCAATGGGGCGTTGGCCCCAAC GAGCAATGGGTCACCAGCCAGGGCCGGGGCCAGGGAAGAGGCTATGAAAGAAGCTGCGGA GCCGCGGACCGCCAGCCTGGAGGAGCTCCGGGAGCTAAAGGGCGTGGTGAAGCTGCAGCG GCGGCACGAGAAGGAGCTGCGAGAGTTGGAGCGGCGCGGAGCGCGGCGCTGGGAGGAGCT GCTGCAGCGGGGCGCGGCGCAGCTGGCGGAGCTCGGGCCACCGGGCGTGGGGGGCGTCGG GGCCTGCAAGCTCGGTCCCGGCAAGGGCTCTCGCAAGAAGAGGAGCCTGCCCCGCGAGGA GAGCGCCGGAGCCGCGCCGGGCGAGGGCCCTGAGGGCGTGGACGGGCGCGTGCGGGAGCT GAAAGACAGGCTGGAGCTGGAGCTGCTGCGGCAGGGCGAGGAGCAGTACGAGTGCGTTCT GAAGCGCAAGGAGCAGCACGTGGCCGAGCAAATCTCCAAAATGATGGAGCTGGCCAGAGA GAAACAGGCGGCAGAGCTGAAGGCCCTGAAGGAGACGTCGGAGAACGACACCAAAGAGAT GAAGAAAAAGCTGGAGACAAAGAGACTGGAGCGGATCCAGGGCATGACCAAAGTCACCAC AGACAAGATGGCCCAGGAGAGGTTGAAGAGAGAGATTAACAACTCCCACATCCAGGAAGT AGTGCAGGTGATCAAGCAGATGACGGAGAACTTGGAGAGGCACCAGGAGAAGCTGGAGGA GAAGCAGGCGGCTTGCCTGGAACAGATACGGGAGATGGAAAAGCAGTTCCAGAAGGAGGC GCTGGCAGAGTACGAGGCCAGGATGAAGGGTCTGGAGGCAGAGGTGAAGGAGTCGGTGAG GGCCTGCCTCAGGACCTGCTTTCCCTCCGAGGCCAAGGACAAGCCTGAGAGGGCCTGCGA GTGCCCCCCAGAGCTGTGTGAGCAGGACCCACTCATAGCAAAGGCAGATGCCCAGGAGAG CCGCCTCTGATGCCCCCATCCCACTGGGACATTTAGCAAGGAGGTTCAGCCCCTTCTCTG GGATGTGGTTCTATTCCCCCAGGAAAAAGGAGCCCCAGCCTTCTGAGGCTGTGGGAACCT GTGGCTGCCTTGGACGCTGCAGCCCCCTCCTCAACGGCCAGGCCAGAGTCTGAGACAGGA CCCAGGCACCCTCACGGCAGGGCCTCTCTGGGGCCTAGAAGTCTTCTCAAGCTGACTTCC TACCTCCCCCTCCATCTCTAGATAAGTGTCATATATTTGTTGAGGGCAAAAGACTATGGA CTGGAAGGCAGAAAGTGGGATCCTGGCCCCACTCTGCCTTTCCTATTGAGCAACCAGCTC TGGGCTCAGTTTCCTCACCTGGAGGGTTGGACCCACTCACCTCCACTCTAGCCCCGAACC CTCCTGCCCCAGGCTTCCAGGCCCCATCAGGCCTGCCCTGAGTTGGCCTTGTCCACTCCT TGAGGCAGATCCTGGCACTACCTCACAGCTCCCTGGGGACGGCCACTCCCTGGCTGAGGG CCCTCCCCTCCCCTCTGCCTGTCCGGAACGGGAGGCTGAAATGGAAAAGCTGCCTTGGCC CTGCTTGGCTGAGTCACAAGGGGCAGTGGGCTCTTGGGTGCTGTTCCACCCTGACCCTGG CTCACCCCTCTTCCTAGGCCTGGGGGCAGGCAGTTCCTACCATGTACCCCTCTCAGGCTG CCTGCCTGACAAGGTCAGCATCATTTGCTCTCCTGAATTTATGAGGTTTATTTATTTTTC TCTTTCCTACTCCTATTAAAGAACCTCGTCCCAGTGTT |
Protein Sequence | >5330 : length: 1192 MSLLNPVLLPPKVKAYLSQGERFIKWDDETTVASPVILRVDPKGYYLYWTYQSKEMEFLD ITSIRDTRFGKFAKMPKSQKLRDVFNMDFPDNSFLLKTLTVVSGPDMVDLTFHNFVSYKE NVGKAWAEDVLALVKHPLTANASRSTFLDKILVKLKMQLNSEGKIPVKNFFQMFPADRKR VEAALSACHLPKGKNDAINPEDFPEPVYKSFLMSLCPRPEIDEIFTSYHAKAKPYMTKEH LTKFINQKQRDSRLNSLLFPPARPDQVQGLIDKYEPSGINAQRGQLSPEGMVWFLCGPEN SVLAQDKLLLHHDMTQPLNHYFINSSHNTYLTAGQFSGLSSAEMYRQVLLSGCRCVELDC WKGKPPDEEPIITHGFTMTTDIFFKEAIEAIAESAFKTSPYPIILSFENHVDSPRQQAKM AEYCRTIFGDMLLTEPLEKFPLKPGVPLPSPEDLRGKILIKNKKNQFSGPTSSSKDTGGE AEGSSPPSAPAGEGTVWAGEEGTELEEEEVEEEEEEESGNLDEEEIKKMQSDEGTAGLEV TAYEEMSSLVNYIQPTKFVSFEFSAQKNRSYVISSFTELKAYDLLSKASVQFVDYNKRQM SRIYPKGTRMDSSNYMPQMFWNAGCQMVALNFQTMDLPMQQNMAVFEFNGQSGYLLKHEF MRRPDKQFNPFSVDRIDVVVATTLSITVISGQFLSERSVRTYVEVELFGLPGDPKRRYRT KLSPSTNSINPVWKEEPFVFEKILMPELASLRVAVMEEGNKFLGHRIIPINALNSGYHHL CLHSESNMPLTMPALFIFLEMKDYIPGAWADLTVALANPIKFFSAHDTKSVKLKEAMGGL PEKPFPLASPVASQVNGALAPTSNGSPAARAGAREEAMKEAAEPRTASLEELRELKGVVK LQRRHEKELRELERRGARRWEELLQRGAAQLAELGPPGVGGVGACKLGPGKGSRKKRSLP REESAGAAPGEGPEGVDGRVRELKDRLELELLRQGEEQYECVLKRKEQHVAEQISKMMEL AREKQAAELKALKETSENDTKEMKKKLETKRLERIQGMTKVTTDKMAQERLKREINNSHI QEVVQVIKQMTENLERHQEKLEEKQAACLEQIREMEKQGSLLSPQFQKEALAEYEARMKG LEAEVKESVRACLRTCFPSEAKDKPERACECPPELCEQDPLIAKADAQESRL |