| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 4261 |
Name | CIITA |
Synonym | C2TA|CIITAIV|MHC2TA|NLRA;class II, major histocompatibility complex, transactivator;CIITA;class II, major histocompatibility complex, transactivator |
Definition | MHC class II transactivator|MHC class II transactivator type III|NLR family, acid domain containing|nucleotide-binding oligomerization domain, leucine rich repeat and acid domain containing |
Position | 16p13 |
Gene Type | protein-coding |
Pathways and Diseases | |
Pathway | Antigen processing and presentation;KEGG PATHWAY;hsa04612 |
Pathway | Toxoplasmosis;KEGG PATHWAY;hsa05145 |
Pathway | Primary immunodeficiency;KEGG PATHWAY;hsa05340 |
Disease | Lupus erythematosus;FunDO |
Disease | Rheumatoid arthritis, susceptibility to;OMIM |
Disease | Combined immunodeficiencies;KEGG DISEASE;H00093 |
Disease | Immunologic deficiency syndrome;FunDO |
Disease | IMMUNE;GAD |
Disease | Multiple myeloma;FunDO |
Disease | Addison's disease;GAD |
Disease | Leukemia;FunDO |
Disease | Ulcerative colitis;NHGRI |
Disease | Yersinia infection;FunDO |
Disease | Autoimmune disease;FunDO |
Disease | Intraocular melanoma;FunDO |
Disease | Celiac disease;NHGRI |
Disease | Celiac Disease;GAD |
Disease | autoimmune inflammatory disease;GAD |
Disease | Primary immunodeficiency;KEGG DISEASE |
Disease | Hepatitis B;FunDO |
Disease | Immune system diseases;KEGG DISEASE |
Disease | Bare lymphocyte syndrome, type II, complementation group A;OMIM |
Disease | multiple sclerosis rheumatoid arthritis;GAD |
Disease | ulcerative colitis;GAD |
Disease | Gastrointestinal cancer;FunDO |
External Links | |
Links to Entrez Gene | 4261 |
Links to all GeneRIF Items | 4261 |
Links to iHOP | 4261 |
Sequence Information | |
Nucleotide Sequence | >4261 : length: 5301 TGTTTTGGATGCTGCATGCTGGGTGAGCGGAGATTCCAGGCACTGGCCAGGGCAGCTGCC CTGACTCCAAGGGCTGCCATGAACAACTTCCAGGCCATCCTGACTCAGGTGAGAATGCTG CTCTCCAGCCATCAGCCCAGCCTGGTGCAGGCCCTCTTGGACAACCTGCTGAAGGAGGAC CTCCTCTCCAGGGAATACCACTGCACTCTGCTCCATGAGCCTGATAGTGAGGCTCTGGCC AGGAAGATCTCTTTGACCCTACTAGAGAAAGGAGACCTGGATTTGGCCCTCCTGGGGTGG GCCCGGAGTGGGCTGCAGCCCCCAGCAGCCGAGAGGGGCCCCGGCCACAGTGACCATGGT GGCAGCTCACAGTGTGCCACCATGGAGTTGGGGCCCCTAGAAGGTGGCTACCTGGAGCTT CTTAACAGCGATGCTGACCCCCTGTGCCTCTACCACTTCTATGACCAGATGGACCTGGCT GGAGAAGAAGAGATTGAGCTCTACTCAGAACCCGACACAGACACCATCAACTGCGACCAG TTCAGCAGGCTGTTGTGTGACATGGAAGGTGATGAAGAGACCAGGGAGGCTTATGCCAAT ATCGCGGAACTGGACCAGTATGTCTTCCAGGACTCCCAGCTGGAGGGCCTGAGCAAGGAC ATTTTCATAGAGCACATAGGACCAGATGAAGTGATCGGTGAGAGTATGGAGATGCCAGCA GAAGTTGGGCAGAAAAGTCAGAAAAGACCCTTCCCAGAGGAGCTTCCGGCAGACCTGAAG CACTGGAAGCCAGCTGAGCCCCCCACTGTGGTGACTGGCAGTCTCCTAGTGGGACCAGTG AGCGACTGCTCCACCCTGCCCTGCCTGCCACTGCCTGCGCTGTTCAACCAGGAGCCAGCC TCCGGCCAGATGCGCCTGGAGAAAACCGACCAGATTCCCATGCCTTTCTCCAGTTCCTCG TTGAGCTGCCTGAATCTCCCTGAGGGACCCATCCAGTTTGTCCCCACCATCTCCACTCTG CCCCATGGGCTCTGGCAAATCTCTGAGGCTGGAACAGGGGTCTCCAGTATATTCATCTAC CATGGTGAGGTGCCCCAGGCCAGCCAAGTACCCCCTCCCAGTGGATTCACTGTCCACGGC CTCCCAACATCTCCAGACCGGCCAGGCTCCACCAGCCCCTTCGCTCCATCAGCCACTGAC CTGCCCAGCATGCCTGAACCTGCCCTGACCTCCCGAGCAAACATGACAGAGCACAAGACG TCCCCCACCCAATGCCCGGCAGCTGGAGAGGTCTCCAACAAGCTTCCAAAATGGCCTGAG CCGGTGGAGCAGTTCTACCGCTCACTGCAGGACACGTATGGTGCCGAGCCCGCAGGCCCG GATGGCATCCTAGTGGAGGTGGATCTGGTGCAGGCCAGGCTGGAGAGGAGCAGCAGCAAG AGCCTGGAGCGGGAACTGGCCACCCCGGACTGGGCAGAACGGCAGCTGGCCCAAGGAGGC CTGGCTGAGGTGCTGTTGGCTGCCAAGGAGCACCGGCGGCCGCGTGAGACACGAGTGATT GCTGTGCTGGGCAAAGCTGGTCAGGGCAAGAGCTATTGGGCTGGGGCAGTGAGCCGGGCC TGGGCTTGTGGCCGGCTTCCCCAGTACGACTTTGTCTTCTCTGTCCCCTGCCATTGCTTG AACCGTCCGGGGGATGCCTATGGCCTGCAGGATCTGCTCTTCTCCCTGGGCCCACAGCCA CTCGTGGCGGCCGATGAGGTTTTCAGCCACATCTTGAAGAGACCTGACCGCGTTCTGCTC ATCCTAGACGGCTTCGAGGAGCTGGAAGCGCAAGATGGCTTCCTGCACAGCACGTGCGGA CCGGCACCGGCGGAGCCCTGCTCCCTCCGGGGGCTGCTGGCCGGCCTTTTCCAGAAGAAG CTGCTCCGAGGTTGCACCCTCCTCCTCACAGCCCGGCCCCGGGGCCGCCTGGTCCAGAGC CTGAGCAAGGCCGACGCCCTATTTGAGCTGTCCGGCTTCTCCATGGAGCAGGCCCAGGCA TACGTGATGCGCTACTTTGAGAGCTCAGGGATGACAGAGCACCAAGACAGAGCCCTGACG CTCCTCCGGGACCGGCCACTTCTTCTCAGTCACAGCCACAGCCCTACTTTGTGCCGGGCA GTGTGCCAGCTCTCAGAGGCCCTGCTGGAGCTTGGGGAGGACGCCAAGCTGCCCTCCACG CTCACGGGACTCTATGTCGGCCTGCTGGGCCGTGCAGCCCTCGACAGCCCCCCCGGGGCC CTGGCAGAGCTGGCCAAGCTGGCCTGGGAGCTGGGCCGCAGACATCAAAGTACCCTACAG GAGGACCAGTTCCCATCCGCAGACGTGAGGACCTGGGCGATGGCCAAAGGCTTAGTCCAA CACCCACCGCGGGCCGCAGAGTCCGAGCTGGCCTTCCCCAGCTTCCTCCTGCAATGCTTC CTGGGGGCCCTGTGGCTGGCTCTGAGTGGCGAAATCAAGGACAAGGAGCTCCCGCAGTAC CTAGCATTGACCCCAAGGAAGAAGAGGCCCTATGACAACTGGCTGGAGGGCGTGCCACGC TTTCTGGCTGGGCTGATCTTCCAGCCTCCCGCCCGCTGCCTGGGAGCCCTACTCGGGCCA TCGGCGGCTGCCTCGGTGGACAGGAAGCAGAAGGTGCTTGCGAGGTACCTGAAGCGGCTG CAGCCGGGGACACTGCGGGCGCGGCAGCTGCTGGAGCTGCTGCACTGCGCCCACGAGGCC GAGGAGGCTGGAATTTGGCAGCACGTGGTACAGGAGCTCCCCGGCCGCCTCTCTTTTCTG GGCACCCGCCTCACGCCTCCTGATGCACATGTACTGGGCAAGGCCTTGGAGGCGGCGGGC CAAGACTTCTCCCTGGACCTCCGCAGCACTGGCATTTGCCCCTCTGGATTGGGGAGCCTC GTGGGACTCAGCTGTGTCACCCGTTTCAGGGCTGCCTTGAGCGACACGGTGGCGCTGTGG GAGTCCCTGCAGCAGCATGGGGAGACCAAGCTACTTCAGGCAGCAGAGGAGAAGTTCACC ATCGAGCCTTTCAAAGCCAAGTCCCTGAAGGATGTGGAAGACCTGGGAAAGCTTGTGCAG ACTCAGAGGACGAGAAGTTCCTCGGAAGACACAGCTGGGGAGCTCCCTGCTGTTCGGGAC CTAAAGAAACTGGAGTTTGCGCTGGGCCCTGTCTCAGGCCCCCAGGCTTTCCCCAAACTG GTGCGGATCCTCACGGCCTTTTCCTCCCTGCAGCATCTGGACCTGGATGCGCTGAGTGAG AACAAGATCGGGGACGAGGGTGTCTCGCAGCTCTCAGCCACCTTCCCCCAGCTGAAGTCC TTGGAAACCCTCAATCTGTCCCAGAACAACATCACTGACCTGGGTGCCTACAAACTCGCC GAGGCCCTGCCTTCGCTCGCTGCATCCCTGCTCAGGCTAAGCTTGTACAATAACTGCATC TGCGACGTGGGAGCCGAGAGCTTGGCTCGTGTGCTTCCGGACATGGTGTCCCTCCGGGTG ATGGACGTCCAGTACAACAAGTTCACGGCTGCCGGGGCCCAGCAGCTCGCTGCCAGCCTT CGGAGGTGTCCTCATGTGGAGACGCTGGCGATGTGGACGCCCACCATCCCATTCAGTGTC CAGGAACACCTGCAACAACAGGATTCACGGATCAGCCTGAGATGATCCCAGCTGTGCTCT GGACAGGAGAAGGAAACCGAGGCTTAGGAGATGAAGTCTGAGGTGTTGGTGGAGCTGGGA TTTAAACCAAAATATGTCCAACTGCAAAGCATGAAAAAGTTGGAAGAGTGCGTATGAAAT AGGCCTGGCAGAAACTATGAGCTGGTGTTCCAAGGTCGGGGATGGGGAGCCCTCACTGGA GGCACCCCTCAAACCCTCAGTGCTGTGGCCAGGGAACCGGGCTGGCAGTCTTAGTTGGCT TTGTTCCCTCGGCCTCCACTTCCCCATTCTGTGCCTCCATTTATTTGTGAGACAGGGATA AAGAGGTCTGCCACTTTTATTGTGATCTTAGGTTTCCCAAAAGCCGAGTATGCTTTCAGA AGTTCTGGGAGGAAAGCTAGCAGATAAACCAGAAATATGAATATCCAAATTGAGAGAAGC CCTCACTTTCTTAGTTCGGCAAAACAGACACATGAGCTGTAAGTGGGGCAGACCCTGCCT GTTTCTTGGCTGAAATCTCCAGTTTGTATAATTCAGGGCTAAGAGAGCAGGACTCTTGAC ATCTCACTGTCTTGAGACACATACTGGGGTTTTCTCCTGTCTGAAGACGCAGCTGGCACC AATGTACCCTATGGCCAAGGACCTTCTGGGTGAGCCTCATGTCAGGAGCAGAGCTGGAGA GGTGGCCAGGCCTGGGGGTATACTTGCCTCCCTGTGTCACCATTGTCTGTCTCTTGCTTA GATGACAGCCACAGCTTCCTGGCCTGGTTTCCTGCATCCGCCCTGACCCCTGGCTGTGGG ATCTCCCATAACTCAAATCTGACTGTGTCCCTGTGGAAGGTTTGGGTTTCTGACCTGGGC AGCTCTATGTCCGGCACAGGGGTTCTGCTGATAGCACAGGCCACAGATTGGCAAGGAGGG ACCAGGTTAGGAAGGAGCAGCTGTGGTTCCTAGTTGGGAGATAACTGAAGCCTAGGAAAT CCTGGAATAAGATAGACCAATGCATCGATAACCCTCAGCTCCAAATCTGAGCTGCACCAG GACAAGCTGACTCTGGTGGCAACGTTCTCCAGTCTCTGCATTTTCAGCTCGCTGTGTGCC AAGAGAGGGCTGGCAGGTACCAGCAGCTTTCACTTTCATTAGGAACCGGGACGAATAATC CAACTGAGCTGCCTCTGCACCAGAACTGCTGGGACGTGAAGACTCTCCCTGGCTCCCAGG CCAGCCACTGCAGCCCTTTCTCCTGGGAAGGAGGGAGCTCCCGATTCCCCATTCCCTGCT CCTGGGCAACAATTAACACTCTAGGAAAACCACAGAGCCGGCTATCCAGGGTTCTGGTGC CCTGGGGACCACAGGGCAGCAAGAAAGTTCTCCTAAGGGTCCTGGGGCTGGGAAGGCAGA GTGGGAAGTCTCCCCCAGCTAGGCTAGACCTGGACCTCCCTGGCACTCAGGCAGCCTGTC CTCTTCTGCTCACAGGATATAAATATTCATGCATGAGTATAGGTGCAGGTTTGTACATTT GCAAGGGCATGGGTATAACACGCTTTCCATTGTATCCGACTATGAATATGAGTGGTTAAT ATTAATACATCTCTTACTATA |
Protein Sequence | >4261 : length: 1229 MLGERRFQALARAAALTPRAAMNNFQAILTQVRMLLSSHQPSLVQALLDNLLKEDLLSRE YHCTLLHEPDSEALARKISLTLLEKGDLDLALLGWARSGLQPPAAERGPGHSDHGGSSQC ATMELGPLEGGYLELLNSDADPLCLYHFYDQMDLAGEEEIELYSEPDTDTINCDQFSRLL CDMEGDEETREAYANIAELDQYVFQDSQLEGLSKDIFIEHIGPDEVIGESMEMPAEVGQK SQKRPFPEELPADLKHWKPAEPPTVVTGSLLVGPVSDCSTLPCLPLPALFNQEPASGQMR LEKTDQIPMPFSSSSLSCLNLPEGPIQFVPTISTLPHGLWQISEAGTGVSSIFIYHGEVP QASQVPPPSGFTVHGLPTSPDRPGSTSPFAPSATDLPSMPEPALTSRANMTEHKTSPTQC PAAGEVSNKLPKWPEPVEQFYRSLQDTYGAEPAGPDGILVEVDLVQARLERSSSKSLERE LATPDWAERQLAQGGLAEVLLAAKEHRRPRETRVIAVLGKAGQGKSYWAGAVSRAWACGR LPQYDFVFSVPCHCLNRPGDAYGLQDLLFSLGPQPLVAADEVFSHILKRPDRVLLILDGF EELEAQDGFLHSTCGPAPAEPCSLRGLLAGLFQKKLLRGCTLLLTARPRGRLVQSLSKAD ALFELSGFSMEQAQAYVMRYFESSGMTEHQDRALTLLRDRPLLLSHSHSPTLCRAVCQLS EALLELGEDAKLPSTLTGLYVGLLGRAALDSPPGALAELAKLAWELGRRHQSTLQEDQFP SADVRTWAMAKGLVQHPPRAAESELAFPSFLLQCFLGALWLALSGEIKDKELPQYLALTP RKKRPYDNWLEGVPRFLAGLIFQPPARCLGALLGPSAAASVDRKQKVLARYLKRLQPGTL RARQLLELLHCAHEAEEAGIWQHVVQELPGRLSFLGTRLTPPDAHVLGKALEAAGQDFSL DLRSTGICPSGLGSLVGLSCVTRFRAALSDTVALWESLQQHGETKLLQAAEEKFTIEPFK AKSLKDVEDLGKLVQTQRTRSSSEDTAGELPAVRDLKKLEFALGPVSGPQAFPKLVRILT AFSSLQHLDLDALSENKIGDEGVSQLSATFPQLKSLETLNLSQNNITDLGAYKLAEALPS LAASLLRLSLYNNCICDVGAESLARVLPDMVSLRVMDVQYNKFTAAGAQQLAASLRRCPH VETLAMWTPTIPFSVQEHLQQQDSRISLR |