Gprc5a functions as a tumor suppressor in mouse lung, and human GPRC5A may share this property.

Loss of GPRC5A is associated with lung adenocarcinomas.

Decreased GPRC5A expression is associated with non-small cell lung cancers and lung inflammation.

Results show how GPRC5A deficiency leads to dysregulated EGFR and STAT3 signaling and lung tumorigenesis.

under-expressed GPRC5A during lung tumorigenesis enhances any transcriptional stimulation through an active translational status.

The lung tumor suppressor gene GPRC5A played a protective role in cigarette smoke-induced lung tumor initiation.

Identification of Sca-1(+)Abcg1(+) bronchioalveolar epithelial cells as the origin of lung adenocarcinoma in Gprc5a-knockout mouse model through the interaction between lung progenitor AT2 and Lgr5 cells.

G protein-coupled receptor family C group 5 member A (GPRC5A) deficiency contributes to dysregulated proto-oncogene protein c-mdm2 (MDM2) via activated epidermal growth factor receptor (EGFR) signaling, which promotes lung tumor development.