We conclude that AFB1 may upregulate IRS2 and stimulate lung cancer cell migration through Src

These data demonstrate for the first time that miR146a suppresses lung cancer progression by repressing IRS2 expression

microRNA-448 inhibits the progression of non-small-cell lung cancer through regulating IRS2.

Circ_0000003 promotes the proliferation and metastasis of non-small cell lung cancer cells via miR-338-3p/insulin receptor substrate 2.

MiRNA-200a-3p suppresses the proliferation, migration and invasion of non-small cell lung cancer through targeting IRS2.

lung-specific dual ablation of insulin receptor substrates 1/2 (succumb to tumor burdenIrs1/Irs2) strongly suppresses tumor initiation and dramatically extends the survival of a mouse model of lung cancer with Kras activation and p53 loss. Mice with Irs1/Irs2 loss eventually.