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Cancer metastasis database

Annotation category 5

Gene information

Gene ID 8660
Symbol

IRS2

Synonymous

IRS-2

Full name

insulin receptor substrate 2

Gene description

-

Cytoband

13q34

Gene type

protein-coding

Synonymous

MIM:600797; HGNC:HGNC:6126; Ensembl:ENSG00000185950; HPRD:02878; Vega:OTTHUMG00000017338

Pathway and disease

Pathways and Diseases

Detail

Pathway

Adipocytokine signaling pathway;KEGG PATHWAY;hsa04920

Pathway

Insulin signaling pathway;KEGG PATHWAY;hsa04910

Pathway

IL4-mediated signaling events;PID Curated;200018

Pathway

IL2-mediated signaling events;PID Curated;200082

Pathway

Neurotrophin signaling pathway;KEGG PATHWAY;hsa04722

Pathway

IGF1 pathway;PID Curated;200084

Pathway

EPO signaling pathway;PID Curated;200157

Pathway

Signaling by Insulin receptor;Reactome;REACT:498

Pathway

Signaling by FGFR;Reactome;REACT:9470

Pathway

Insulin/IGF pathway-protein kinase B signaling cascade;PANTHER;P00033

Pathway

Interleukin signaling pathway;PANTHER;P00036

Pathway

Type II diabetes mellitus;KEGG PATHWAY;hsa04930

Pathway

Signalling by NGF;Reactome;REACT:11061

Pathway

Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade;PANTHER;P00032

Pathway

Aldosterone-regulated sodium reabsorption;KEGG PATHWAY;hsa04960

Pathway

Signaling events regulated by Ret tyrosine kinase;PID Curated;200058

Disease

longevity;GAD

Disease

Insulin Resistance;GAD

Disease

diabetes, type 2;GAD

Disease

polycystic ovarian syndrome;GAD

Disease

CANCER;GAD

Disease

METABOLIC;GAD

Disease

obesity;GAD

Disease

AGING;GAD

Disease

Diabetes mellitus, noninsulin-dependent;OMIM

Disease

colorectal cancer;GAD

Sequence Information

Nucleotide Sequence

>8660 : length: 7014
CGGGGACCGCGACGAGCCCGGGTCGCCGTTGGCAGCAGCAGCAGCAACACCAGCAGCAGCAGCAGCCCCGGCGGCGGCGCGGACCCCGAGCGCCCGGGCGCACCCCGGCTTCCCGGAGCG
CGACGCGGCGGCAGCAGCCCCGGTGCGGCCGCGCGCGCCTTAGGCTCGGCCCCGCGGCTCGGGGACCCCGACTCCCGGCCCAGCGAGCGCGTCCCCCGGCGCCGCCCGAGAGCCCGAGGA
GGCAGCGGCCGCAGGCAGCCGGGGAGGGGGGCGGCCACCGCCCGCGCCGGGCATCCTCAGGAGCCCCAGAGCGCGGAGGGCGCGGCGCCGCCGAGCGGTGCTGGCCCCCGCGGGCCTCCC
CGGACCTTCCCCACCGCCTGGGCCCGAGGGACGCGTGATCGGGCGGGCGGCCGGGCGCAAGGGTGGGAGGGAGCCGCCCCCGCCCGCGCCCCCTCCGCCCCTCGCCCCAACCCCTGGGCG
CCGGGCCCGGGCCGCGCGGCCTGAAGCGCCCGCGATGGCGAGCCCGCCGCGGCACGGGCCGCCCGGGCCGGCGAGCGGAGACGGCCCCAACCTCAACAACAACAACAACAACAACAACCA
CAGCGTGCGCAAGTGCGGCTACCTGCGCAAGCAGAAGCATGGCCACAAGCGCTTCTTCGTGCTGCGCGGACCCGGCGCGGGCGGCGACGAGGCGACGGCGGGCGGGGGGTCGGCGCCGCA
ACCGCCGCGGCTCGAGTACTACGAGAGCGAGAAAAAGTGGCGGAGCAAGGCAGGCGCGCCGAAACGGGTGATCGCTCTCGACTGCTGCCTGAACATCAACAAGCGCGCCGACGCCAAGCA
CAAGTACCTGATCGCCCTCTACACCAAGGACGAGTACTTCGCCGTGGCCGCCGAGAACGAGCAGGAGCAGGAGGGCTGGTACCGCGCGCTCACCGACCTGGTCAGCGAGGGCCGCGCGGC
CGCCGGAGACGCGCCCCCCGCCGCCGCGCCCGCCGCGTCCTGCAGCGCCTCCCTGCCCGGCGCCCTGGGCGGCTCTGCCGGCGCCGCCGGGGCCGAGGACAGCTACGGGCTGGTGGCTCC
CGCCACGGCCGCCTACCGTGAGGTGTGGCAGGTGAACCTGAAGCCCAAGGGTCTGGGCCAGAGCAAGAACCTGACGGGGGTGTACCGTCTGTGCCTGTCTGCGCGCACCATCGGCTTCGT
GAAGCTCAACTGCGAGCAGCCGTCGGTGACGCTGCAGCTCATGAACATCCGCCGCTGCGGCCACTCGGACAGCTTCTTCTTCATCGAGGTGGGCCGCTCGGCCGTCACAGGCCCCGGCGA
GCTGTGGATGCAGGCGGACGACTCGGTGGTGGCGCAGAACATCCACGAGACCATCCTGGAGGCCATGAAGGCGCTCAAGGAGCTCTTCGAGTTCCGGCCGCGCAGTAAGAGCCAATCGTC
GGGGTCGTCGGCCACGCACCCCATCAGCGTCCCCGGCGCGCGCCGCCACCACCACCTGGTCAACCTGCCCCCCAGCCAGACGGGCCTGGTGCGCCGCTCGCGCACCGACAGCCTGGCCGC
CACCCCGCCGGCGGCCAAGTGCAGCTCGTGCCGGGTGCGCACCGCCAGCGAGGGCGACGGCGGCGCGGCGGCGGGAGCGGCGGCCGCGGGCGCCAGGCCGGTGTCGGTGGCTGGGAGCCC
CCTGAGCCCCGGGCCGGTGCGCGCGCCCCTGAGCCGCTCGCACACCCTGAGCGGCGGCTGCGGCGGCCGCGGGAGCAAGGTGGCGCTGCTGCCGGCAGGGGGCGCGCTGCAACACAGCCG
CTCCATGTCCATGCCCGTGGCGCACTCGCCGCCCGCCGCCACCAGCCCCGGCTCCCTGTCGTCCAGCAGCGGCCACGGCTCGGGCTCCTACCCGCCGCCGCCCGGCCCGCACCCGCCTCT
GCCGCATCCGCTGCACCACGGCCCCGGCCAGCGGCCCTCCAGCGGCAGCGCCTCCGCCTCGGGCTCCCCCAGCGACCCCGGCTTCATGTCCCTGGACGAGTACGGCTCCAGCCCAGGCGA
CCTGCGCGCCTTCTGCAGCCACCGAAGCAACACGCCCGAGTCCATCGCGGAGACGCCCCCGGCCCGAGACGGCGGCGGCGGCGGTGAGTTCTACGGGTACATGACCATGGACAGGCCCCT
GAGCCACTGTGGCCGCTCCTACCGCCGGGTCTCGGGGGACGCGGCCCAGGACCTGGACCGAGGGCTGCGCAAGAGGACCTACTCCCTGACCACGCCAGCCCGGCAGCGGCCGGTGCCCCA
GCCCTCCTCTGCCTCGCTGGATGAATACACCCTGATGCGGGCCACCTTCTCGGGCAGCGCGGGCCGCCTCTGCCCGTCCTGCCCCGCGTCCTCTCCCAAGGTGGCCTACCACCCCTACCC
AGAGGACTACGGAGACATCGAGATCGGCTCCCACAGGAGCTCCAGCAGCAACCTGGGGGCAGACGACGGCTACATGCCCATGACGCCCGGCGCGGCCCTCGCGGGCAGTGGGAGCGGCAG
CTGCAGGAGCGACGACTACATGCCCATGAGCCCCGCCAGCGTGTCCGCCCCCAAGCAGATCTTGCAGCCCAGGGCCGCCGCCGCCGCCGCCGCCGCCGTGCCTTCTGCGGGGCCTGCGGG
GCCAGCACCCACCTCTGCGGCGGGCAGGACATTCCCGGCGAGCGGGGGCGGCTACAAGGCCAGCTCGCCCGCCGAGAGCTCCCCCGAGGACAGTGGGTACATGCGCATGTGGTGCGGTTC
CAAGCTGTCCATGGAGCATGCAGATGGCAAGCTGCTGCCCAACGGGGACTACCTCAACGTGTCCCCCAGCGACGCGGTCACCACGGGCACCCCGCCCGACTTCTTCTCCGCAGCCCTGCA
CCCCGGCGGGGAGCCGCTCAGGGGCGTTCCCGGCTGCTGCTACAGCTCCTTGCCCCGCTCCTACAAGGCCCCCTACACCTGTGGCGGGGACAGCGACCAGTACGTGCTCATGAGCTCCCC
CGTGGGGCGCATCCTGGAGGAGGAGCGTCTGGAGCCTCAGGCCACGCCAGGGCCCAGCCAGGCGGCCAGCGCCTTCGGGGCCGGCCCCACGCAGCCCCCTCACCCTGTAGTGCCTTCGCC
CGTGCGGCCTAGCGGCGGCCGCCCGGAGGGCTTCTTGGGCCAGCGCGGCCGGGCGGTGAGGCCCACGCGCCTGTCCCTGGAGGGGCTGCCCAGCCTGCCCAGCATGCACGAGTACCCACT
GCCACCGGAGCCCAAGAGCCCCGGCGAGTACATCAACATCGACTTTGGCGAGCCCGGGGCCCGCCTGTCGCCGCCCGCGCCTCCCCTGCTGGCGTCGGCGGCCTCGTCCTCCTCGCTCTT
GTCCGCCAGCAGCCCGGCCTCGTCGCTGGGCTCAGGCACCCCGGGCACCAGCAGCGACAGCCGGCAGCGGTCTCCGCTCTCCGACTACATGAACCTCGACTTCAGCTCCCCCAAGTCTCC
TAAGCCGGGCGCCCCGAGCGGCCACCCCGTGGGCTCCTTGGACGGCCTCCTGTCCCCCGAGGCCTCCTCCCCGTATCCGCCGTTGCCCCCGCGTCCGTCCGCGTCCCCGTCGTCGTCTCT
GCAGCCGCCGCCACCGCCGCCGGCCCCGGGGGAGCTGTACCGCCTGCCCCCCGCCTCGGCCGTTGCCACCGCCCAGGGCCCGGGCGCCGCCTCATCGTTGTCCTCGGACACCGGGGACAA
TGGTGACTACACCGAGATGGCTTTTGGTGTGGCCGCCACCCCGCCGCAACCTATCGCGGCCCCCCCGAAGCCAGAAGCTGCCCGCGTGGCCAGCCCGACGTCGGGCGTGAAGAGGCTGAG
CCTCATGGAGCAGGTGTCGGGAGTCGAGGCCTTCCTGCAGGCCAGCCAGCCCCCGGACCCCCACCGCGGCGCCAAGGTCATCCGCGCAGACCCGCAGGGGGGCCGCCGCCGCCACAGTTC
CGAGACCTTCTCCTCCACCACGACGGTCACCCCCGTGTCCCCGTCCTTCGCCCACAACCCCAAGCGCCACAACTCGGCCTCCGTGGAAAATGTCTCTCTCAGGAAAAGCAGCGAGGGCGG
CGTGGGTGTCGGCCCTGGAGGGGGCGACGAGCCGCCCACCTCCCCACGACAGTTGCAGCCGGCGCCCCCTTTGGCACCGCAGGGCCGGCCGTGGACCCCGGGTCAGCCCGGGGGCTTGGT
CGGTTGTCCTGGGAGCGGTGGATCGCCCATGCGCAGAGAGACCTCTGCCGGCTTCCAGAATGGTCTCAACTACATCGCCATCGACGTGAGGGAGGAGCCCGGGCTGCCACCCCAGCCGCA
GCCGCCGCCGCCGCCGCTTCCTCAGCCGGGAGACAAGAGCTCCTGGGGCCGGACCCGAAGCCTCGGGGGTCTCATCAGCGCTGTGGGCGTCGGCAGCACCGGCGGCGGGTGCGGGGGGCC
GGGTCCCGGTGCCCTGCCCCCTGCCAACACCTACGCCAGCATTGACTTCTTGTCCCACCACTTGAAGGAGGCCACCATCGTGAAAGAGTGAAGATCTGTCTGGCTTTATCACCAGGATGT
CACATGTCAGAGAGTATCATTAAAAGAAGACGCTCAGCACTGTTTCAGCCCGAAGCTGCTTGCAGTTTTCTTTTGGATCTGAGCAATGACTGTGTTTGGAAACATCTGTGGACTCTGTTA
GATGAGGCACCAACAAGGCAAGGTCACCTGCCTCTTTCCCTTGTTCCCGGATGGGGCATTCATCATTGTGCTGTTTGCGTTTTGTTTTGTTTTGTTTTAACAAAATTAGCTGAAGAAGTT
ATTCTCAAGAAAATTGGATGTTTTCATTGGCCTTCTTAAATTGTGGCCAGTGTCTTTTAATTTCTTCTTCTTTTCCTTTTGGCAAAGCAGATATAACCCTCAGCATGCTAGGAGAGTGCA
CCCGTACCTATGGAAGTGGTAAAATCTGGTATTTACTGGCTTACACTCAAAACGACCACAGTCCTACCTCAGTTCAAGGTAAAGCCGGATTTCCGTGGCGGGGGTCCCACAGGACCTCCT
GTAGTAGCCCCTGCGCTGTGTGTCTGGAGCGCGGTCCTCGGCCTTATTGAAATGGTCCAAGTAGACAGCTGCTTGTTGGATTCCAGTGCAGGTACCTGCGATGTTTACGTCCACACCGAG
CCCAGTGTGGGACTGACATTTCTCAATGGAAGTGAAATTTGGGATTGGACTTTGAAGACGGATTACTAAATAATAATTATTATATGTAACTGAAGCAACCTACTTTTGAAAATCAACTGT
ATTGGGTAGTGGGAGGTGGGAGGGAAGGGCTTTGGGAAGGGGATGAATATCTCTTTTTACCTTTAACAGACTTGTTTAATCTTCTCGATGTAGATGTTTATGTAGGTACTTCACATTGCA
AACGCCTTTTATTCTATTTACAAGCTCAGATGTCTCTGCTCTCCTGAATCTTGGGCATGCCTTTCTGTAACCAAAAATCCCTGTAGGCGTGCTAGCAATTCCAGGGTGGTCCGGGTTTGG
CAGATTTGATTTTTAAAAAACGTATTATCTTTAATAAAATGTTATTATGTCAACCAGTGAGGCTGCCCTGAACAAAAAAAACAAAAAGAAAAAAAAAAAAGGAAAGAAAGAAACTGATAA
AAAGAGGCATTCCAGCCCCTATGTTATTGATGGAAAAAGAAAAAGAAGAAAAGCAATCTCGCAGTACATGTTACTTGTCGAAAAAATTCCGGACAAGACTACCCTTGTTTTATGTTTTCA
GTATTCTGAAAATACCAGTGTGTGGCAGTTCTCGCAGATGTTACCTAAAACTGCTGAACTTGACCGGCAGAATGTTCTGCCGTTTTCTGCTCCCTCGACACTTGATTGGAGGGCTGTCGA
CCTCTCCTCCCGTGGGGGCTTCCCCAGTGCCTATCTTCTCTGATAGTCATGGAGAGGTTACACTAATTCATTGGAGATGTAAGTTGTTGGTTTTGTTTTGTTTTGTTTTTAGAAAAATAT
ATATAAATATATAATAGATATCTATCGCTATAGAATAATGCATTAATAAAATGAGGCTTTTTTAGAGGAAGACCAAAAAATTCAATGTCTTAAAAATATATTTAATGGCAATGCAAAAGT
CTTCCTGCTTCCGTGCTGAACTTTAGAACAGAGGATTGTATTGCAAGACAAAGTTGAATGTAAAGTGATCTCCCTGAACATTTTTAAGGTTTTACTTTTCTGAAATTATACATCACAGCA
GTGCATAGGCCATATAATGTTAGCTGGAAGGTCAATTTCAGTGTATGATATACTTTATTAAGATGTATAAAAATCCTGAAGTTTTTATTTAGTTTTGGGAATAGGCATCAATGGGTGGTA
TTTGCTTTGTAACTCCCCCCAGGTACGATAGGGACTGAATATGGACCCTGCTGAAAGCAGTGTATTGACGCATATTTAACTCGCCCTCTATCCGTAGAGTAGTCATGACACTATACAGAT
GGTTCGTGTTCATACTGCAGCTTAAAACAAGCAAAATACACAGATGATAATATGCTAAATTTTCCTCTATCCTGTACATTTCACAAAAAGGCATATGCAATATTTACATTTTTAATTTAG
TTTACAGAATGGAACCAAAATGTATAAATGTTATGTTTGCTAAAACTTCACAATGTATATTGGGTCTTTGTACATTTTGCCTGACTTACCTTAAATTTAAAATATTTTTTGCTATATAAA
CTTTAACAGTTATTAAACAGTGTTTTCTTTTTGGGTACGTATTGTTTCTGGATATCAAGATGTTAAATATATTTCTTGCTATTGTGATATGACAAGAGACTTAACTTATCTTGCTCTGTC
TTCCACTGTACACGCTGTATATAGGGGTCAATGTGATGCTGCTGGAGACGAGAATAAACTGGACTAGAATAGTGCATTGTATTTAGTCTGTATTGATCATGGATGCCCTCCTTAATAGCC
ATATGCAATAAAATAAAGTACATTATTTATGAAATGAAAAAAAAAAAAAAAAAA

Protein Sequence

>8660 : length: 1338
MASPPRHGPPGPASGDGPNLNNNNNNNNHSVRKCGYLRKQKHGHKRFFVLRGPGAGGDEATAGGGSAPQPPRLEYYESEKKWRSKAGAPKRVIALDCCLNINKRADAKHKYLIALYTKDE
YFAVAAENEQEQEGWYRALTDLVSEGRAAAGDAPPAAAPAASCSASLPGALGGSAGAAGAEDSYGLVAPATAAYREVWQVNLKPKGLGQSKNLTGVYRLCLSARTIGFVKLNCEQPSVTL
QLMNIRRCGHSDSFFFIEVGRSAVTGPGELWMQADDSVVAQNIHETILEAMKALKELFEFRPRSKSQSSGSSATHPISVPGARRHHHLVNLPPSQTGLVRRSRTDSLAATPPAAKCSSCR
VRTASEGDGGAAAGAAAAGARPVSVAGSPLSPGPVRAPLSRSHTLSGGCGGRGSKVALLPAGGALQHSRSMSMPVAHSPPAATSPGSLSSSSGHGSGSYPPPPGPHPPLPHPLHHGPGQR
PSSGSASASGSPSDPGFMSLDEYGSSPGDLRAFCSHRSNTPESIAETPPARDGGGGGEFYGYMTMDRPLSHCGRSYRRVSGDAAQDLDRGLRKRTYSLTTPARQRPVPQPSSASLDEYTL
MRATFSGSAGRLCPSCPASSPKVAYHPYPEDYGDIEIGSHRSSSSNLGADDGYMPMTPGAALAGSGSGSCRSDDYMPMSPASVSAPKQILQPRAAAAAAAAVPSAGPAGPAPTSAAGRTF
PASGGGYKASSPAESSPEDSGYMRMWCGSKLSMEHADGKLLPNGDYLNVSPSDAVTTGTPPDFFSAALHPGGEPLRGVPGCCYSSLPRSYKAPYTCGGDSDQYVLMSSPVGRILEEERLE
PQATPGPSQAASAFGAGPTQPPHPVVPSPVRPSGGRPEGFLGQRGRAVRPTRLSLEGLPSLPSMHEYPLPPEPKSPGEYINIDFGEPGARLSPPAPPLLASAASSSSLLSASSPASSLGS
GTPGTSSDSRQRSPLSDYMNLDFSSPKSPKPGAPSGHPVGSLDGLLSPEASSPYPPLPPRPSASPSSSLQPPPPPPAPGELYRLPPASAVATAQGPGAASSLSSDTGDNGDYTEMAFGVA
ATPPQPIAAPPKPEAARVASPTSGVKRLSLMEQVSGVEAFLQASQPPDPHRGAKVIRADPQGGRRRHSSETFSSTTTVTPVSPSFAHNPKRHNSASVENVSLRKSSEGGVGVGPGGGDEP
PTSPRQLQPAPPLAPQGRPWTPGQPGGLVGCPGSGGSPMRRETSAGFQNGLNYIAIDVREEPGLPPQPQPPPPPLPQPGDKSSWGRTRSLGGLISAVGVGSTGGGCGGPGPGALPPANTY
ASIDFLSHHLKEATIVKE