Links to all GeneRIF Items | 841 |
PubMed (Gene Name) | Literature evidence |
|---|---|
| 12037669 (CASP8) | alteration associated with nodal metastasis in non-small cell lung cancer |
| 12170765 (CASP8) | CASP8 may function as a tumor suppressor gene in neuroendocrine lung tumors. |
| 12700635 (CASP8) | caspase 8 has a critical role in apoptosis in the death receptor pathway in small cell lung carcinoma cell lines |
| 16242324 (CASP8) | caspase-3, -8, and -9 activity is enhanced by safrole oxidase in lung cancer cells |
| 16938569 (CASP8) | Polymorphisms and their haplotypes in the CASP-8 gene can result in alterations in CASP-8 expression and/or activity, thereby modulating the susceptibility to lung cancer. |
| 19203830 (CASP8) | Coding polymorphisms in Casp5, Casp8 and DR4 genes may play a role in predisposition to lung cancer. |
| 19543235 (CASP8) | Procaspase 8 is frequently overexpressed in non-small-cell lung cancers and that this preferentially sensitizes non-small-cell lung cancers cells to apoptosis induced by FLIP silencing. |
| 22691345 (CASP8) | Caspase-8 is not only an apoptosis protein, but has non-apoptosis function, such as promoting invasion and metastasis of lung cancer A549 cell. |
| 22843554 (CASP8) | Genetic variations in CASP8 and CASP10 may act as potential predictive biomarkers for platinum-based chemotherapy toxicity in Chinese non-small cell lung cancer patients. |
| 25214386 (CASP8) | Studied the mechanism of Artemisinin (ARTE)-induced human lung adenocarcinoma (ASTC-a-1) cell apoptosis; results showed ARTE induced the activation of caspase-3, -8 and -9. |
| 26988918 (CASP8) | CASP8: rs1045494 (C > T), PIK3R1: rs3756668 (A > G) and CASP7: rs4353229 (T > C), were associated with longer overall survival in limited disease-small cell lung cancer patients after chemoradiotherapy |
| 27195913 (CASP8) | Dasatinib, a c-Src inhibitor, dephosphorylated caspase-8 to facilitate necroptosis, rather than apoptosis, in paclitaxel-treated p-Casp8-expressing lung adenocarcinoma cells. |
| 27465556 (CASP8) | Overexpression of CASP8 is associated with lung cancer. |
| 28278082 (CASP8) | The polymorphisms of CASP8, rs7608692, and haplotype AGAACAG correlated with neutropenia toxicity. The haplotype GGGGAAA was associated with thrombocytopenia toxicity. We conclude that the polymorphisms of CASP8 contribute to the prognosis of advanced lung adenocarcinoma and influence the quality of life and survival. |