Links to all GeneRIF Items | 8140 |
PubMed (Gene Name) | Literature evidence |
|---|---|
| 18253116 (SLC7A5) | Overexpression of L-type amino acid transporter 1 is associated with nonsmall cell lung cancer |
| 19068093 (SLC7A5) | Elevated expression of CD98 is associated with squamous cell carcinoma of the lung. |
| 19171406 (SLC7A5) | over expression of Lat1 is a pathological factor to predict the prognosis in patients with resectable stage I pulmonary adenocarcinoma |
| 19430419 (SLC7A5) | the percentage of lung carcinoma patients remaining unclassifiable by TTF-1/TP63 was twice that of the five-antibody (TRIM29, CEACAM5, SLC7A5, MUC1, and CK5/6) test |
| 19559497 (SLC7A5) | higher mRNA levels in non-small-cell lung carcinomas compared to normal lung tissues |
| 19635099 (SLC7A5) | Multivariate analysis confirmed that positive expression of LAT1 was an independent factor for predicting a poor prognosis in surgically resected stage I non-small cell lung cancer. |
| 19777189 (SLC7A5) | High LAT1 expression is associated with non-small-cell lung cancer with lymph node metastases. |
| 21055621 (SLC7A5) | LAT1 expression is a stronger prognostic factor than (18)F-FAMT uptake in surgically resected non-small cell lung cancer |
| 22110199 (SLC7A5) | High LAT1 expression is associated with drug resistance in non-small cell lung cancer. |
| 27566573 (SLC7A5) | LAT1-NAD+-SIRT1 signaling is activated in tumor tissues of patients with non-small cell lung cancer; NAD+ synthesis regulates the SIRT1-FOXO1 apoptotic pathway in response to NQO1 |
| 29277611 (SLC7A5) | Thus, our results indicated that lncRNA-PVT1-5 may function as a competing endogenous RNA (ceRNA) for miR-126 to promote cell proliferation by regulating the miR-126/SLC7A5 pathway, suggesting that lncRNA-PVT1-5 plays a crucial role in lung cancer progression and lncRNA-PVT1-5/miR-126/SLC7A5 regulatory network may shed light on tumorigenesis in lung cancer. |
| 29326164 (SLC7A5) | Data suggest that amino acid uptake via ASCT2/SLC1A5 is required for cell proliferation/tumor growth independently of LAT1/SLC7A5; in part, these studies were conducted in lung and colon adenocarcinoma cell lines and involved gene knockout techniques. (ASCT2/SLC1A5 = solute carrier family-1 member-5; LAT1/SLC7A5 = solute carrier family-7 member-5) |
| 30300664 (SLC7A5) | LAT1 and 4F2hc were identified as significant independent markers for predicting a worse prognosis in patients with pulmonary pleomorphic carcinoma |
| 30528230 (SLC7A5) | Dysfunction of MINCR, miR-126 and SLC7A5 predicted poor prognosis of patients with non-small cell lung cancer. |