Cancer metastasis database

Annotation category 5

Gene information

Gene ID 8140
Symbol

SLC7A5

Synonymous

4F2LC|CD98|D16S469E|E16|LAT1|MPE16|hLAT1

Full name

solute carrier family 7 (amino acid transporter light chain, L system), member 5

Gene description

4F2 LC|4F2 light chain|CD98 light chain|L-type amino acid transporter 1|integral membrane protein E16|large neutral amino acids transporter 1|large neutral amino acids transporter small subunit 1|sodium-independent neutral amino acid transporter LAT1|solu

Cytoband

16q24.3

Gene type

protein-coding

Synonymous

MIM:600182; HGNC:HGNC:11063; Ensembl:ENSG00000103257; HPRD:02552; Vega:OTTHUMG00000137658

COSMIC somatic mutation

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.125_130delAGGGCG; p.E42_G43delEG; 16:87869293-87869298

 lungcarcinoma; small_cell_carcinomaDeletion - In frame

c.822G>A; p.L274L; 16:87839819-87839819

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.1158C>T; p.L386L; 16:87836630-87836630

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.1470C>G; p.F490L; 16:87833024-87833024

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.1290+8C>T; p.?; 16:87836490-87836490

 skin; trunkmalignant_melanoma; nodularUnknown

c.1083C>T; p.S361S; 16:87837902-87837902

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - coding silent

c.735G>T; p.L245L; 16:87841085-87841085

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.160A>G; p.N54D; 16:87869263-87869263

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.301C>T; p.L101F; 16:87869122-87869122

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.1410C>T; p.P470P; 16:87834472-87834472

 pancreascarcinomaSubstitution - coding silent

c.1475C>T; p.T492M; 16:87833019-87833019

 pancreascarcinomaSubstitution - Missense

c.1077G>C; p.L359L; 16:87837908-87837908

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.166G>T; p.V56L; 16:87869257-87869257

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.963C>T; p.G321G; 16:87838794-87838794

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.1332C>T; p.L444L; 16:87834550-87834550

 urinary_tract; bladdercarcinomaSubstitution - coding silent

c.1332C>T; p.L444L; 16:87834550-87834550

 urinary_tract; bladdercarcinoma; transitional_cell_carcinomaSubstitution - coding silent

c.934G>T; p.A312S; 16:87839707-87839707

 central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - Missense

c.345C>A; p.G115G; 16:87869078-87869078

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.934G>T; p.A312S; 16:87839707-87839707

 central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - Missense

c.939+7C>T; p.?; 16:87839695-87839695

 haematopoietic_and_lymphoid_tissuehaematopoietic_neoplasm; acute_myeloid_leukaemiaUnknown

c.853G>A; p.V285M; 16:87839788-87839788

 livercarcinomaSubstitution - Missense

c.853G>A; p.V285M; 16:87839788-87839788

 livercarcinomaSubstitution - Missense

c.1341C>T; p.I447I; 16:87834541-87834541

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.1384T>C; p.F462L; 16:87834498-87834498

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.693C>A; p.F231L; 16:87841127-87841127

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.368T>C; p.V123A; 16:87869055-87869055

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.558C>A; p.N186K; 16:87851830-87851830

 ovaryother; neoplasmSubstitution - Missense

c.1053C>T; p.F351F; 16:87837932-87837932

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.243G>T; p.S81S; 16:87869180-87869180

 pancreascarcinomaSubstitution - coding silent

c.584G>A; p.R195Q; 16:87851804-87851804

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.606C>T; p.A202A; 16:87851782-87851782

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - coding silent

c.732G>C; p.V244V; 16:87841088-87841088

 lungcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.990C>T; p.F330F; 16:87838767-87838767

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.1519A>G; p.T507A; 16:87832975-87832975

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.648C>T; p.F216F; 16:87851740-87851740

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - coding silent

c.1480G>A; p.V494I; 16:87833014-87833014

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.1480G>A; p.V494I; 16:87833014-87833014

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1290+9G>A; p.?; 16:87836489-87836489

 oesophagus; lower_thirdcarcinoma; adenocarcinomaUnknown

c.687C>T; p.P229P; 16:87841133-87841133

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - coding silent

c.923C>G; p.S308C; 16:87839718-87839718

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1224_1225GG>AA; p.A409T; 16:87836563-87836564

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.578C>T; p.A193V; 16:87851810-87851810

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.946G>A; p.G316R; 16:87838811-87838811

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.809C>T; p.P270L; 16:87840435-87840435

 skinmalignant_melanomaSubstitution - Missense

c.1518G>C; p.E506D; 16:87832976-87832976

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.786C>T; p.F262F; 16:87840458-87840458

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - coding silent

c.937G>A; p.V313M; 16:87839704-87839704

 central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - Missense

c.1186G>A; p.V396I; 16:87836602-87836602

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.1015G>A; p.V339I; 16:87838742-87838742

 stomachcarcinoma; intestinal_adenocarcinomaSubstitution - Missense

c.1221C>T; p.C407C; 16:87836567-87836567

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.764G>C; p.G255A; 16:87841056-87841056

 adrenal_gland; adrenal_glandadrenal_cortical_carcinoma; functioningSubstitution - Missense

c.193G>A; p.G65S; 16:87869230-87869230

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.961G>A; p.G321S; 16:87838796-87838796

 livercarcinoma; hepatocellular_carcinomaSubstitution - Missense

c.891C>T; p.F297F; 16:87839750-87839750

 skinmalignant_melanomaSubstitution - coding silent

c.924C>T; p.S308S; 16:87839717-87839717

 large_intestinecarcinoma; adenocarcinomaSubstitution - coding silent

c.679C>G; p.L227V; 16:87841141-87841141

 breastcarcinomaSubstitution - Missense

c.1161C>T; p.Y387Y; 16:87836627-87836627

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - coding silent

c.658G>A; p.G220R; 16:87851730-87851730

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.930C>T; p.A310A; 16:87839711-87839711

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.1162G>A; p.A388T; 16:87836626-87836626

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.59A>C; p.E20A; 16:87869364-87869364

 oesophaguscarcinoma; adenocarcinomaSubstitution - Missense

c.720G>T; p.V240V; 16:87841100-87841100

 prostatecarcinoma; adenocarcinomaSubstitution - coding silent

c.931G>A; p.V311M; 16:87839710-87839710

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.739T>C; p.L247L; 16:87841081-87841081

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - coding silent

c.1282C>T; p.P428S; 16:87836506-87836506

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.282C>T; p.V94V; 16:87869141-87869141

 breastcarcinomaSubstitution - coding silent

c.1342G>A; p.A448T; 16:87834540-87834540

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1117C>T; p.P373S; 16:87837868-87837868

 stomachcarcinoma; adenocarcinomaSubstitution - Missense