The susceptibility region contains two genes, TERT and CLPTM1L, suggesting that one or both may have a role in lung cancer etiology.

the lung cancer susceptibility locus Tert-Clptm1l on chromosome 5p15.33 increases the risk for bronchial obstruction and emphysema.

Single-nucleotide polymorphisms in CLPTM1L is associated with lung cancer.

The CT genotype at rs401681 was more common and the TT genotype was rare in patients, and the differences were significant between lung adenocarcinoma patients and controls. This was also true for rs402710. Moreover, the frequency of the GGCTCT haplotype was higher and the TTTTTT frequency was lower in patients, especially those with lung adenocarcinoma.

This study implicates anti-apoptotic CLPTM1L function as a potential mechanism of susceptibility to lung tumorigenesis and resistance to chemotherapy.

CLPTM1L is a mitochondria protein that may be associated with an anti-apoptotic mechanism which affects drug-resistance in lung cancer cells.

results suggest that genetic variants in the TERT-CLPTM1L gene may predispose individuals to be susceptible to lung cancer, particularly non-small cell lung cancer, in the Chinese population

The 5p15.33 region containing telomerase reverse transcriptase gene (TERT) and cleft lip and palate transmembrane protein 1-like (CLPTM1L) gene showed significant association with lung cancer in Han Chinese.

Our results reiterate that genetic variants of TERT and CLPTM1L contribute to lung cancer susceptibility in Chinese population.

Longer telomere length in peripheral white blood cells is associated with risk of lung cancer and the rs2736100 (CLPTM1L-TERT) polymorphism.

The 5p15.33 locus involving CLPTM1L polymorphisms is significantly associated with lung cancer risk.

Genetic variants in TERT and CLPTM1L may affect the susceptibility of lung cancer

Polymorphism in CLPTM1L gene is associated with lung cancer.

CLPTM1L SNPs (rs401681 and rs4975616) were not associated with non-small cell lung cancer in a non-smoking Han Chinese population.

A protumorigenic role for CLPTM1L that is critical for Ras-driven lung cancers, with potential implications for therapy and chemosensitization.

the role of TERT-CLPTM1L variants in the etiology of esophageal squamous cell carcinoma and lung cancer

CLPTM1L rs31489 was a potential biomarker for lung cancer risk in Caucasians

our study indicated that the CLPTM1L - rs401681 (G>A) polymorphism was significantly associated with decreased lung cancer risk, especially among European populations.

CLPTM1L-rs401681 polymorphism was not associated with lung cancer risk in Chinese males.

CLPTM1L polymorphisms rs402710 and rs401681 are risk-conferring factors for the development of lung cancer. [Meta-analysis]

Our meta-analysis provides supportive evidence that CRR9p polymorphism may influence a risk of lung cancer and non-small cell lung cancer in a protective model.

association of the CLPTM1L polymorphism and the risk of the lung cancer in non-smoking females in China

This study showed that genetic variation rs31489 in 5p15.33 was directly associated with the reduced risk of lung cancer in Han Chinese. The CLPTM1L gene rs31489-A allele was a protective factor for the development of lung cancer only in nonsmokers.

consumption of alcohol may interact with CLPTM1L polymorphisms to contribute to overall lung cancer susceptibility.

rs2736100 on TERT-CLPTM1L indicates a poor prognosis for lung cancer in the Chinese Han population.

A case-control study examined the potential association of 4 CLPTM1L SNPs (rs4975616, rs402710, rs401681, and rs31489) with lung cancer in a Chinese Han population. Minor alleles of all four were significantly associated with decreased lung cancer risk.

The data demonstrate that CLPTM1L overexpression can predict poor prognosis in patients with lung cancer and suggest that CLPTM1L might be associated with the regulation of cell migration and invasion.

Variant in CLPTM1L gene is associated with lung cancer susceptibility.

rs401681 and rs402710 single nucleotide polymorphism of CLPTM1L might be the causal SNPs for lung cancer in East Asian

Both TERT-rs33963617 and CLPTM1L-rs77518573 conferred reduced risk for Non small cell lung cancer in Chinese Han population.