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Cancer metastasis database

Annotation category 5

Literatures

Literature evidence

Links to all GeneRIF Items

7980

PubMed (Gene Name)

Literature evidence

21983100 (TFPI2)

TFPI-2 methylation is associated with non-small cell lung cancer.

25414083 (TFPI2)

TMPRSS4 is upregulated by silencing of TFPI-2 through aberrant DNA methylation and contributes to oncogenesis in non-small cell lung cancer.

29845195 (TFPI2)

These results suggest that LSD2 achieves a promoting effect on small cell lung cancer by indirectly regulating TFPI2 expression through the mediation of DNMT3B expression or through the regulation of the demethylation of H3K4me1 in the promoter region of the TFPI2 gene.