lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	7980
Symbol	TFPI2
Synonymous	PP5\|REF1\|TFPI-2
Full name	tissue factor pathway inhibitor 2
Gene description	placental protein 5\|retinal pigment epithelium cell factor 1
Cytoband	7q22
Gene type	protein-coding
Synonymous	MIM:600033; HGNC:HGNC:11761; Ensembl:ENSG00000105825; HPRD:08962; Vega:OTTHUMG00000022963

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.395G>A; p.R132Q; 7:93889100-93889100	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.395G>A; p.R132Q; 7:93889100-93889100	prostate	adenoma	Substitution - Missense
c.239A>G; p.E80G; 7:93890169-93890169	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.66C>T; p.G22G; 7:93890613-93890613	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.411C>G; p.N137K; 7:93889084-93889084	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.408G>T; p.E136D; 7:93889087-93889087	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.54G>A; p.E18E; 7:93890625-93890625	skin	malignant_melanoma	Substitution - coding silent
c.274G>C; p.V92L; 7:93889221-93889221	liver	carcinoma	Substitution - Missense
c.473G>A; p.C158Y; 7:93887419-93887419	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.375C>A; p.F125L; 7:93889120-93889120	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.183C>T; p.C61C; 7:93890225-93890225	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.127G>A; p.G43R; 7:93890281-93890281	liver	carcinoma	Substitution - Missense
c.127G>A; p.G43R; 7:93890281-93890281	liver	carcinoma	Substitution - Missense
c.689T>A; p.I230N; 7:93886839-93886839	thyroid	other; neoplasm	Substitution - Missense
c.530A>G; p.N177S; 7:93887362-93887362	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.530A>G; p.N177S; 7:93887362-93887362	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.235T>C; p.W79R; 7:93890173-93890173	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.147T>A; p.L49L; 7:93890261-93890261	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.419C>T; p.P140L; 7:93889076-93889076	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.217G>A; p.A73T; 7:93890191-93890191	large_intestine; colon	NS	Substitution - Missense
c.385G>A; p.G129R; 7:93889110-93889110	oesophagus	carcinoma	Substitution - Missense
c.10G>T; p.A4S; 7:93890669-93890669	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.325T>A; p.S109T; 7:93889170-93889170	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.325T>A; p.S109T; 7:93889170-93889170	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.571T>G; p.C191G; 7:93887321-93887321	breast	carcinoma	Substitution - Missense
c.182G>T; p.C61F; 7:93890226-93890226	thyroid	carcinoma; anaplastic_carcinoma	Substitution - Missense
c.698A>C; p.K233T; 7:93886830-93886830	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.271+1G>T; p.?; 7:93890136-93890136	thyroid	carcinoma	Unknown
c.264G>A; p.R88R; 7:93890144-93890144	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.524A>G; p.Y175C; 7:93887368-93887368	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.382G>A; p.G128S; 7:93889113-93889113	breast	carcinoma	Substitution - Missense
c.114G>A; p.L38L; 7:93890294-93890294	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.184C>T; p.R62C; 7:93890224-93890224	breast	carcinoma	Substitution - Missense
c.322G>T; p.G108W; 7:93889173-93889173	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.290G>A; p.R97Q; 7:93889205-93889205	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.263G>A; p.R88K; 7:93890145-93890145	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.14G>A; p.R5H; 7:93890665-93890665	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.400C>T; p.R134W; 7:93889095-93889095	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.170A>G; p.Y57C; 7:93890238-93890238	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.692G>A; p.R231Q; 7:93886836-93886836	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.692G>A; p.R231Q; 7:93886836-93886836	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.692G>A; p.R231Q; 7:93886836-93886836	skin	malignant_melanoma	Substitution - Missense
c.555T>C; p.A185A; 7:93887337-93887337	pancreas	carcinoma	Substitution - coding silent
c.555T>C; p.A185A; 7:93887337-93887337	pancreas	carcinoma	Substitution - coding silent
c.288C>T; p.C96C; 7:93889207-93889207	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.553G>T; p.A185S; 7:93887339-93887339	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.616C>T; p.R206C; 7:93887276-93887276	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.616C>T; p.R206C; 7:93887276-93887276	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.616C>T; p.R206C; 7:93887276-93887276	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.188A>G; p.Q63R; 7:93890220-93890220	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.691C>T; p.R231W; 7:93886837-93886837	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.691C>T; p.R231W; 7:93886837-93886837	skin	malignant_melanoma	Substitution - Missense
c.691C>T; p.R231W; 7:93886837-93886837	skin	malignant_melanoma	Substitution - Missense
c.182G>A; p.C61Y; 7:93890226-93890226	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.636G>A; p.L212L; 7:93886892-93886892	skin	malignant_melanoma	Substitution - coding silent
c.97G>A; p.A33T; 7:93890311-93890311	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.97G>A; p.A33T; 7:93890311-93890311	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.85A>C; p.T29P; 7:93890594-93890594	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.381C>T; p.S127S; 7:93889114-93889114	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.381C>T; p.S127S; 7:93889114-93889114	skin	malignant_melanoma	Substitution - coding silent
c.578G>A; p.G193E; 7:93887314-93887314	skin	malignant_melanoma	Substitution - Missense
c.460+10A>G; p.?; 7:93889025-93889025	liver	carcinoma	Unknown
c.98C>T; p.A33V; 7:93890310-93890310	oesophagus; lower_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.98C>T; p.A33V; 7:93890310-93890310	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.98C>T; p.A33V; 7:93890310-93890310	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.517C>T; p.R173C; 7:93887375-93887375	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.471T>G; p.F157L; 7:93887421-93887421	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.309C>G; p.D103E; 7:93889186-93889186	pancreas	NS	Substitution - Missense
c.196T>C; p.Y66H; 7:93890212-93890212	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.387delG; p.C130fs*42; 7:93889108-93889108	breast	carcinoma	Deletion - Frameshift
c.195G>T; p.L65L; 7:93890213-93890213	breast	carcinoma	Substitution - coding silent
c.699G>A; p.K233K; 7:93886829-93886829	breast	carcinoma	Substitution - coding silent
c.336G>T; p.K112N; 7:93889159-93889159	liver	carcinoma	Substitution - Missense
c.198C>T; p.Y66Y; 7:93890210-93890210	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.682C>T; p.R228W; 7:93886846-93886846	skin	malignant_melanoma	Substitution - Missense
c.624T>G; p.C208W; 7:93887268-93887268	skin	malignant_melanoma	Substitution - Missense
c.665G>A; p.R222H; 7:93886863-93886863	endometrium	carcinoma; serous_carcinoma	Substitution - Missense
c.665G>A; p.R222H; 7:93886863-93886863	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.257G>A; p.C86Y; 7:93890151-93890151	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.665G>A; p.R222H; 7:93886863-93886863	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.216C>T; p.N72N; 7:93890192-93890192	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.136C>T; p.R46W; 7:93890272-93890272	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.102G>A; p.E34E; 7:93890306-93890306	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.664C>T; p.R222C; 7:93886864-93886864	urinary_tract; bladder	carcinoma	Substitution - Missense
c.664C>T; p.R222C; 7:93886864-93886864	skin	malignant_melanoma	Substitution - Missense
c.664C>T; p.R222C; 7:93886864-93886864	urinary_tract; bladder	carcinoma	Substitution - Missense
c.338A>G; p.Y113C; 7:93889157-93889157	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.683G>A; p.R228Q; 7:93886845-93886845	oesophagus	carcinoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation