Strong CXCR4-positive nuclear staining was associated with a significantly better outcome in early-stage non-small-cell lung cancer (NSCLC).

EGF and hypoxia induce CXCR4 in non-small cell lung cancer, a process regulated by the PI3-kinase/PTEN/AKT/mTOR signaling pathway and activation of HIF-1alpha

Overexpression of CXCR4 is associated with the metastatic potential of human non-small cell lung cancer

CXCR4/CXCL12 interactions may play a role in the accumulation of CXCR4-expressing T cells and a subset of CD25high regulatory T cells within non-small cell lung cancer (NSCLC)tissue.

bone marrow-derived-SDF-1alpha enhances the invasiveness of lung cancer cells by increasing MMP-9 expression through the CXCR4/ERK/NF-kappaB signal transduction pathway

Breast cancer metastasis suppressor 1 inhibits SDF-1alpha-induced migration of non-small cell lung cancer by decreasing CXCR4 expression.

The association between aberrant expression of CXCR4 in the nucleus of non-small cell lung cancer and metastasis to lymph nodes points toward a potential tumor metastasis promoting function of nuclear CXCR4.

CXCR4/SDF-1 pathway was critical for TLR9 agonist to enhance the metastasis of human lung cancer cells.

expression correlates with a favorable prognosis in patients with lung adenocarcinoma

We studied a unique cohort of 21 primary lung cancers with matched adrenal metastases for the expression of CX3CR1, CXCR4, CCR6, and CCR7

there is a significant association between the polymorphisms of CXCL12 and CXCR4, and the susceptibility to and prognosis of non-small cell lung cancer

Interaction between carcinoma-associated fibroblasts and tumor epithelial cells through the CXCL12/CXCR4 axis plays a role in non-small cell lung cancer tumor proliferation.

CXCR4 overexpression is associated with stage IV non-small cell lung cancer.

RNAi-mediated silencing of VEGF-C inhibits non-small cell lung cancer progression by simultaneously down-regulating the CXCR4, CCR7, VEGFR-2 and VEGFR-3-dependent axes-induced ERK, p38 and AKT signalling pathways.

data provide the first evidence that CXCR4 signaling has a functional role in the maintenance of stemness of non-small cell lung cancer cells

These findings suggest a possible role for the CXCL12/CXCR4 axis in the metastatic evolution of non-small-cell lung cancer

Elevated levels of CXCR4 and MMP-9 are found in small cell lung cancer tissues. CXCR4 expression might be correlated with bone metastasis. CXCR4 is an independent prognostic factor for disease-free survival in SCLC.

Both CXCR3 and CXCR4 are involved in metastasis of colorectal cancer to lymph nodes, lungs and liver.

Targeting the CXCL12/CXCR4 axis with BKT140 attenuated non-small cell lung cancer cell tumor growth and augmented the effects of chemotherapy and radiotherapy.

Studies indicate involvement of the CXCR4 receoptor/CXCL12 chemokine signaling axis in non-small-cell lung cancer (NSCLC) metastasis to the brain.

CXCL12 and CXCR4 have a single ligand-single receptor relationship in mediating non-small cell lung cancer migration and metastasis, and in context of NSCLC that expresses CXCR4, the CXCR4-CXCL12 axis is not involved in angiogenesis of the primary tumor

ERbeta and CXCL12/CXCR4 expression in lung adenocarcinoma depends on sex and hormonal status, which may partly explain the sex and hormonal differences in lung cancer behavior.

these data suggest that uPAR and CXCR4 co-expression predicts worse prognosis of small cell lung cancer patients

meta-analysis suggest that CXCR4 expression is associated with an increased risk and worse survival in non-small cell lung cancer patients; the aberrant CXCR4 expression plays an important role in the carcinogenesis and metastasis of NSCLC

HIF-1alpha and reactive oxygen species mediate radiation-induced invasiveness through the SDF-1alpha/CXCR4 pathway in non-small cell lung carcinoma cells.

microenvironment stimuli eliciting epithelial-to-mesenchymal transition are able to increase the dissemination potential of lung cancer cells through the generation of the CD133(+)/CXCR4(+)/EpCAM(-) subset.

CXCR4 signaling has a role in radiation-induced lung damage that promotes breast cancer lung-metastasis

Higher percentage of CXCR4-expressing lung metastatic cells compared to the corresponding primary tumors point to important functions of the CXCL12/CXCR4 axis in late steps of metastasis

From our data we conclude that targeting of CXCR4 and FAK may overcome ABCB1 and ABCC1-dependent doxorubicin resistance in non-small cell lung carcinoma cells

High CXCR4 expression is associated with cisplatin-resistance in non-small cell lung cancer.

these results suggest that the CD133/CXCR4/epithelial-mesenchymal transition axis may be a prognostic marker and may provide novel targets for combinational therapies in the treatment of non-small cell lung cancer

this study shows that cytoplasmic CXCR4 seems to correlate with biomarker changes associated with epithelial to mesenchymal transition in non-small-cell lung cancer

co-expression of C-X-C chemokine receptor 4 and Notch1 is associated with tumor progression and lymphovascular invasion and is an independent indicator of poor survival in lung adenocarcinoma. In lung adenocarcinoma patients with high C-X-C chemokine receptor 4 and Notch1 expression, simultaneous inhibition of both factors might be an effective treatment strategy.

p65 O-GlcNAcylation promotes lung metastasis of cervical cancer cells by activating CXCR4 expression.

Results has shown that CXCR4 was highly expressed in non-small cell lung cancer (NSCLC) tissues and metastatic lymph nodes. CXCR4 expression levels was significantly correlated with lymph node metastasis in NSCLC. Along with VEGF-C, CXCR4 might synergically promote lymphatic metastasis in lung cancer and might be a clinical predictor of lymph node metastasis in NSCLC patients.

Results show that CXCR4 is highly expressed in the primary site of non-small cell lung neoplasm (NSCLC) and is associated with poor prognosis which suggest that CXCR4 may play a role in tumor progression of NSCLC.

Results demonstrated that miR-1246 inhibited cell invasion and EMT process by targeting CXCR4 and blocking JAK/STAT and PI3K/AKT signal pathways in lung cancer cells.

The tissue expressions of CD68 and CXCR4 in non-small cell lung cancer tissues were significantly correlated with a higher TNM staging and lymph node metastasis (p<0.05); and the expression of CD68 was positively correlated with the expression of CXCR4 (r=0.461, p=0.000).

Daily oral administration of AMD070 significantly inhibited the lung metastasis of B88SDF1 cells in nude mice. These results indicated that AMD070 could be useful as a novel orally bioavailable inhibitor of oral cancer metastasis

EGFR Over-expression and mutations Leading to Biological Characteristics Changes of Human lung Adenocarcinoma Cells through CXCR4/CXCL12 Signaling pathway

High CXCR4 expression is associated with differential expression patterns in adenocarcinoma and squamous cell carcinoma of the lung relative to small cell lung cancer.

The overexpression of CXCR4 increased sVCAM1, and the sVCAM1 secreted from CXCR4-overexpressing non-small cell lung carcinoma cells recruited and arrested additional osteoclast progenitors to promote osteoclastogenesis.

LncNORAD interference inhibits tumor growth and lung cancer cell proliferation, invasion and migration by down-regulating CXCR4 to suppress RhoA/ROCK signaling pathway.

CXCR4 expression in lung carcinogenesis: Evaluating gender-specific differences in survival outcomes based on CXCR4 expression in early stage non-small cell lung cancer patients.

CXCR4 positive cells from Lewis lung carcinoma cell line have cancer metastatic stem cell characteristics