polymorphism and risk of lung cancer in a Chinese population

The XRCC1 variant allele did not show any effect on the p53 mutation in lung tumors.

Cumulative cigarette smoking plays an important role in altering the direction and magnitude of the associations between the XRCC1 and ERCC2 polymorphisms and lung cancer risk.

genetic variants in APEX1 and XRCC1 may alter the risk of lung cancer in a special population in China

XRCC1 polymorphism contributes to the etiology of lung cancer

identification of polymorphisms in lung carcinoma of never smokers

Our results show that the genetic variation in XRCC1, XRCC3 and NBS1 influence lung cancer susceptibility among women, and that combinations of risk alleles in the two HR genes can enhance the effects.

The results have suggested that the XRCC1 gene might be the risk genotype for lung cancer in this population.

this prospective investigation provides suggestive evidence of a favorable effect of the XRCC1399 Gln/Gln genotype on survival in platinum-treated non-small-cell lung cancer and, for the first time, in small-cell lung carcinoma patients also

Haplotypes of nine single nucleotide polymorphisms in ERCC1, ERCC2 and XRCC1 genes on chromosome 19q13.2-3 is associated with lung cancer

XRCC1 Arg399Gln and T-77C polymorphisms may alter the risk of lung cancer in women nonsmokers in China

review summarizes the literature and discusses the relevance of XRCC1 polymorphisms and lung cancer risk [review]

Results showed no evidence of a relationship between the XRCC1 Arg194Trp and Arg399Gln polymorphisms and the risk of lung and colorectal cancer.

findings further suggest that the polymorphisms XRCC1 Arg194Trp and Pro206Pro or the haplotype encompassing the variant alleles may contribute to susceptibility of lung cancer in a Chinese population

the polymorphic status of XRCC1 194Arg/Trp might be a predictive marker of treatment response for advanced non-small cell lung carcinoma

XRCC1 gene polymorphism is associated with non-small cell lung cancer.

no association between genetic polymorphism and the increased risk of lung cancer in Chinese population (Meta-analysis)

XRCC1 gene polymorphisms is associated with favorable clinical outcome in advanced non-small-cell lung cancer.

XRCC1 codon 399 and 194 variant may affect the susceptibility of lung cancer.

The non-small lung cancer patients with the XRCC1 codon 194 C/T+T/T polymorphisms were 2.038 times as sensitive to the chemotherapy as the patients with C/C genotype.

Genetic polymorphisms in ERCC1 and XRCC1 genes might be prognostic factors in non-smoking female patients with lung adenocarcinoma.

XRCC1 gene polymorphism is not associated with outcome of platinum-based chemotherapy for advanced non small cell lung cancers.

Single-nucleotide polymorphism in XRCC1 is associated with small-cell lung cancer.

XRCC1 Arg194Trp polymorphism is associated with lung cancer.

Our findings indicated that neither XPD Lys751Gln nor XRCC1 T-77C could be genetic determinant for prognosis of advanced non-small cell lung cancer patients treated with platinum-based chemotherapy

XRCC1 codon 399 polymorphism is not associated with response to chemptherapy in non-small cell lung cancer.

The combined effects of polymorphisms within OGG1, APE1 and XRCC1 genes may contribute to the tumorigenesis of lung cancer

Polymorphisms of GSTP1 and XRCC1 may explain differences in chemosensitivity in Non-small cell lung cancer treated with platinum-based regimens. GSTP1A313G and XRCC1G28152A polymorphisms were significantly associated with response to treatment.

Genetic polymorphisms in XRCC1 gene might be associated with overall survival and response to platinum-based chemotherapy in lung cancer patients.

cAMP signaling system inhibits the repair of gamma-ray-induced DNA damage by promoting the ubiquitin-proteasome dependent degradation of XRCC1 in an Epac1-dependent pathway in lung cancer cells.

The genetic polymorphisms of CYP1A1-exon7, GSTM1, XRCC1-194 and XRCC1-280 might contribute to the risk of developing lung cancer in Henan population.

Codon 194, codon 399 and -77 T > C polymorphisms of XRCC1 gene might have contributed to individual susceptibility to lung cancer. [Meta-analysis]

The interaction of polymorphisms of XRCC1-194 Trp/Trp, XRCC1-280 His/His with smoking resulted in the increased risk of lung cancer.

Non-small-cell lung cancer patients carrying XRCC1 Arg194Arg, FAS-1377GG, and FASL-844T allele displayed completely no response to platinum based drugs, whereas patients with XRCC1 194Trp allele had 68.8% response rate to platinum antineoplastic agents.

XRCC1 Arg194Trp and XRCC1Arg399Gln single nucleotide polymorphisma were related to the metabolism of platinum-based chemotherapy, and could be used as predictors of clinical outcome of non-small cell lung cancer.

an independent and synergistic contribution of XRCC1 Arg399Gln and XRCC3 Thr241Met polymorphisms to lung cancer susceptibility in northeastern Chinese

XRCC1 Arg399Gln, PARP1 Va1762Ala and APE1 Asp148Glu SNPs in the base excision repair pathway may influence the prognosis of advanced non-small cell lung cancer patients following platinum-based chemotherapy

XRCC1 Arg194Trp polymorphism is associated with increased risk of lung cancer in Chinese Han population. [Meta-analysis]

Female carrying XPC and XRCC1 polymorphic genotypes had significantly increased risk of lung cancer.

A three-order interaction among the polymorphic sites of XPD-751, XRCC1-399, and OGG1-326 is associated with lung adenocarcinoma risk.

There is a significant association between XRCC1 codon 280 polymorphism and increased risk of lung cancer. [Meta-analysis]

Studies indicate there was an obvious association between XRCC1 Arg399Gln polymorphism and increased risk of lung cancer in Chinese.

codon 399 polymorphism of XRCC1 gene might contribute to individual's susceptibility to lung cancer in Asian population, and especially in nonsmoking Chinese women.

XRCC1 -77T>C shows an increased lung cancer risk and XRCC3 T241M polymorphism is associated with decreased lung cancer risk, especially in Caucasians. [meta-analysis]

XRCC1 SNPs (rs2256507 and rs1001581) were not associated with non-small cell lung cancer in a non-smoking Han Chinese population.

The codon 399 Arg/Gln XRCC1 polymorphism is associated with lung cancer.

there is a significant association of XRCC1 rs3213245 polymorphism with lung cancer risk

XRCC1 Arg194Trp polymorphism was not associated with lung cancer risk

The combined Gln/Gln genotype of XRCC1 and XPD genes was significantly associated with increased risk for lung cancer.

The XRCC1 c.1178G>A genetic polymorphism was associated with an increased risk of lung cancer

The xrcc1 rs1799782 played an important role in preventing lung cancer in Caucasians.

Studied the relationship between XRCC1 genetic variants and lung cancer susceptibility in Chinese Han lung cancer patients.

Study provides evidence that genetic polymorphisms in XPD-751, XRCC1-194 and XRCC1-399 were all correlated with non-small cell lung cancer occurrence.

Preliminary results suggested that the XRCC1 c.482C>T and c.1686C>G genetic variants might play genetic effects on the susceptibility to lung cancer.

Results for the meta-analysis showed that the XRCC1 -77T>C polymorphism might be related to increased risk of lung cancer in Asians.

the C > T, rs1799782 and C > T, rs25487 of XRCC1 genetic variants might be used as molecular markers for detecting lung cancer susceptibility.

Data indicate that two polymorphisms (rs2854509 and rs7248167) that were predicted to affect XRCC1 DNA repair protein expression based on their RegulomeDB scores were not associated with lung cancer risk.

we evaluated the association of gene polymorphisms, including the repair genes of XRCC1, ERCC1, ERCC2 (XPD), and TP53, with RFS in patients with non-small cell lung cancer

XRCC1 Arg399Gln gene polymorphism is associated with lung cancer.

XRCC1 mutations are associated with response to therapy in non-small cell lung cancer patients.

Down-regulation of XRCC1 expression by resveratrol can enhance the chemosensitivity to etoposide in non-small lung cancer cells, via ERK1/2 and AKT signaling .

XRCC1 Arg399Gln gene polymorphism might influence the response to cisplatin-based chemotherapy and affect the clinical outcome of advanced non-small cell lung carcinoma.

the GSTP1 rs1695 and XRCC1 rs25487 polymorphisms might affect the clinical outcome of patients with advanced non-small cell lung cancer receiving cisplatin-based chemotherapy.

Our data demonstrated that the SNPs rs25487 and rs1052133 are risk factors for lung cancer in epidemiologically susceptible Chinese people.

the GSTP1 Ile105Val and XRCC1 Arg194Trp were associated with better response to chemotherapy and longer survival of advanced non-small cell lung cancer

we suggest that GSTP1 Ile105Val and XRCC1 Arg399Gln polymorphisms could influence the response to chemotherapy and sur-vival of advanced non-small cell lung carcinoma.

Our data indicates that the c.1804C>A genetic variant of XRCC1 is statistically associated with the susceptibility to lung cancer in the Chinese population

This study revealed a positive association of XRCC1 Gln632Gln towards lung cancer, however XRCC1 Arg399Gln, Arg194Trp showed an overall no effect or protective effect.

The analysis results showed that the following polymorphisms were correlated with susceptibility to lung cancer: rs4646903 in CYP1A1 (P < 0.001), rs1048943 in CYP1A1 (P < 0.001), rs1695 in GSTP1 (P < 0.05), rs13181 in ERCC2 (P < 0.001), and rs25487 in XRCC1 (P < 0.05); no such correlation existed in rs861539 in XRCC3 (P > 0.05).

Meta-analysis: in Non-Small-Cell lung Carcinoma patients treated with platinum-based regimen, XRCC1 194Arg allele suggest poor objective response rate, the GlnGln genotype of XRCC1 399 suggest poorer overall survival in Caucasian patients, and longer PFS in Asian patients.

This study demonstrates that the presence of His allele and Gln allele in case of SULT1A1 rs9282861 and XRCC1 rs25487, respectively, involve in lung cancer prognosis in Bangladeshi population.

T-77C and Arg399Gln polymorphisms of the XRCC1 gene, as well as the 186C>T and Val158Met polymorphisms of the COMT gene, increased the risk of lung cancer in non-smoking women.

The TP53 codon 72 Arg allele and XRCC1 codon 399 Gln allele are likely to have a protective effect against lung adenocarcinoma, especially in individuals older than 50 years of age. XRCC1 and TP53 genotyping might be a useful low-cost tool for evaluating individual lung cancer risk.

Increased lung cancer risk was revealed in workers-carriers of homozygous minor genotype of genes OGG1] Ser326Cys (OR - 4.67, p = 0.007), APE1 Asp148Glu (OR = 1.82, p = 0.063) and XRCC1 Gln399Arg (OR = 2.86, p = 0.026).

XRCC1 and XPD polymorphisms, cooking oil mist, and soot exposure history may be interactively correlated with non-small-cell lung cancer incidence for nonsmoking female patients.

Study used polygenic approach for the first time to obtain evidence about repair genes in determining lung cancer susceptibility in North Indian population and evaluated synonymous polymorphisms of XRCC1 for the first time in lung cancer. Combination of XRCC1 632 and OGG 1326 showcased a high risk of eightfold and XRCC1 632 and MUTYH 324 had a high risk.

Radiation-induced lymphopenia during chemoradiation therapy for non-small cell lung cancer is linked with age, lung V5, and XRCC1 rs25487 genotypes in lymphocytes.

SIRT1 confers chemoresistance to lung cancer cells by deacetylating and stabilizing XRCC1.