lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	7515
Symbol	XRCC1
Synonymous	RCC
Full name	X-ray repair complementing defective repair in Chinese hamster cells 1
Gene description	DNA repair protein XRCC1\|X-ray repair cross-complementing protein 1
Cytoband	19q13.2
Gene type	protein-coding
Synonymous	MIM:194360; HGNC:HGNC:12828; Ensembl:ENSG00000073050; HPRD:01909; Vega:OTTHUMG00000182699

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.1542G>C; p.P514P; 19:43545897-43545897	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.1190C>T; p.P397L; 19:43551580-43551580	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1190C>T; p.P397L; 19:43551580-43551580	breast	carcinoma	Substitution - Missense
c.783A>C; p.P261P; 19:43552837-43552837	breast	carcinoma	Substitution - coding silent
c.976G>T; p.V326L; 19:43552123-43552123	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.34T>C; p.C12R; 19:43575425-43575425	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1842T>C; p.S614S; 19:43543452-43543452	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1372A>G; p.K458E; 19:43546649-43546649	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1657G>A; p.E553K; 19:43544199-43544199	liver	carcinoma	Substitution - Missense
c.737G>C; p.R246T; 19:43552883-43552883	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1170C>A; p.H390Q; 19:43551600-43551600	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.912C>T; p.T304T; 19:43552187-43552187	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1103C>T; p.P368L; 19:43551667-43551667	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1270G>A; p.E424K; 19:43546907-43546907	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1414G>A; p.G472R; 19:43546607-43546607	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.1563G>A; p.E521E; 19:43545876-43545876	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.580C>T; p.R194W; 19:43553422-43553422	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1563G>A; p.E521E; 19:43545876-43545876	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - coding silent
c.322G>A; p.V108I; 19:43554738-43554738	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1759G>A; p.A587T; 19:43543641-43543641	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.618A>G; p.P206P; 19:43553075-43553075	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1200G>A; p.R400R; 19:43546977-43546977	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.1892C>T; p.P631L; 19:43543402-43543402	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1171C>T; p.R391C; 19:43551599-43551599	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1896A>G; p.Q632Q; 19:43543398-43543398	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1896A>G; p.Q632Q; 19:43543398-43543398	thyroid	other; neoplasm	Substitution - coding silent
c.1171C>T; p.R391C; 19:43551599-43551599	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1233G>A; p.E411E; 19:43546944-43546944	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.224C>T; p.S75L; 19:43560941-43560941	oesophagus	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1270G>T; p.E424*; 19:43546907-43546907	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.513C>A; p.G171G; 19:43553489-43553489	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.536A>T; p.D179V; 19:43553466-43553466	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.380G>T; p.R127L; 19:43554680-43554680	skin	malignant_melanoma	Substitution - Missense
c.504C>T; p.T168T; 19:43553498-43553498	skin	malignant_melanoma	Substitution - coding silent
c.1794G>C; p.L598L; 19:43543500-43543500	breast	carcinoma	Substitution - coding silent
c.1494G>A; p.Q498Q; 19:43545945-43545945	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.711+2T>G; p.?; 19:43552980-43552980	breast	carcinoma	Unknown
c.920G>A; p.R307K; 19:43552179-43552179	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.869G>A; p.R290Q; 19:43552230-43552230	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1196A>G; p.Q399R; 19:43551574-43551574	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1653C>T; p.Y551Y; 19:43544203-43544203	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.243G>C; p.E81D; 19:43560922-43560922	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.400C>T; p.Q134*; 19:43554660-43554660	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.520C>T; p.R174C; 19:43553482-43553482	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.641C>T; p.A214V; 19:43553052-43553052	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1626C>A; p.F542L; 19:43544230-43544230	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.183G>A; p.G61G; 19:43560982-43560982	skin	malignant_melanoma	Substitution - coding silent
c.736A>G; p.R246G; 19:43552884-43552884	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.736A>G; p.R246G; 19:43552884-43552884	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.736A>G; p.R246G; 19:43552884-43552884	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.787G>A; p.A263T; 19:43552833-43552833	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1381T>C; p.S461P; 19:43546640-43546640	breast	carcinoma; basal_(triple-negative)_carcinoma	Substitution - Missense
c.385A>G; p.K129E; 19:43554675-43554675	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1185G>A; p.R395R; 19:43551585-43551585	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.765G>C; p.K255N; 19:43552855-43552855	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1870C>T; p.H624Y; 19:43543424-43543424	breast	carcinoma	Substitution - Missense
c.1361C>A; p.P454H; 19:43546660-43546660	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.712-1G>T; p.?; 19:43552909-43552909	stomach	carcinoma; adenocarcinoma	Unknown
c.1048C>T; p.R350W; 19:43552051-43552051	skin	malignant_melanoma	Substitution - Missense
c.1048C>T; p.R350W; 19:43552051-43552051	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1384C>T; p.P462S; 19:43546637-43546637	breast	carcinoma; basal_(triple-negative)_carcinoma	Substitution - Missense
c.70C>T; p.L24F; 19:43574984-43574984	breast	carcinoma	Substitution - Missense
c.445T>G; p.F149V; 19:43553653-43553653	soft_tissue; striated_muscle	rhabdomyosarcoma	Substitution - Missense
c.1498G>A; p.E500K; 19:43545941-43545941	urinary_tract; bladder	carcinoma	Substitution - Missense
c.52A>G; p.T18A; 19:43575002-43575002	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1136G>A; p.R379H; 19:43551634-43551634	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1804C>T; p.P602S; 19:43543490-43543490	skin	malignant_melanoma	Substitution - Missense
c.254A>G; p.E85G; 19:43560911-43560911	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1446G>A; p.A482A; 19:43546087-43546087	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.898C>T; p.R300*; 19:43552201-43552201	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.1264G>A; p.G422R; 19:43546913-43546913	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.808C>G; p.P270A; 19:43552812-43552812	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.548A>T; p.N183I; 19:43553454-43553454	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1360_1361CC>TT; p.P454F; 19:43546660-43546661	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1819G>A; p.V607I; 19:43543475-43543475	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1819G>A; p.V607I; 19:43543475-43543475	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.103G>C; p.A35P; 19:43574951-43574951	prostate	carcinoma	Substitution - Missense
c.839G>A; p.R280H; 19:43552260-43552260	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.839G>A; p.R280H; 19:43552260-43552260	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.839G>A; p.R280H; 19:43552260-43552260	thyroid	other; neoplasm	Substitution - Missense
c.1002C>T; p.F334F; 19:43552097-43552097	skin	malignant_melanoma	Substitution - coding silent
c.292G>A; p.E98K; 19:43554768-43554768	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1798G>C; p.D600H; 19:43543496-43543496	pancreas	carcinoma; acinar_carcinoma	Substitution - Missense
c.1677G>A; p.R559R; 19:43544179-43544179	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.474A>T; p.A158A; 19:43553624-43553624	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.1074G>A; p.T358T; 19:43552025-43552025	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1141G>A; p.V381M; 19:43551629-43551629	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1074G>A; p.T358T; 19:43552025-43552025	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1074G>A; p.T358T; 19:43552025-43552025	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1074G>A; p.T358T; 19:43552025-43552025	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1074G>A; p.T358T; 19:43552025-43552025	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1598A>G; p.D533G; 19:43545841-43545841	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.423C>T; p.P141P; 19:43553675-43553675	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1655G>A; p.G552E; 19:43544201-43544201	skin	malignant_melanoma	Substitution - Missense
c.998C>T; p.P333L; 19:43552101-43552101	skin	malignant_melanoma	Substitution - Missense
c.320G>A; p.R107H; 19:43554740-43554740	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.544G>A; p.A182T; 19:43553458-43553458	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.174G>A; p.V58V; 19:43560991-43560991	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.1231G>A; p.E411K; 19:43546946-43546946	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1207A>G; p.M403V; 19:43546970-43546970	lung	carcinoma; undifferentiated_carcinoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation