Links to all GeneRIF Items | 7099 |
PubMed (Gene Name) | Literature evidence |
|---|---|
| 17328955 (TLR4) | TLR4 expressed on human lung cancer cells is functionally active, and may play important roles in promoting immune escape of human lung cancer cells by inducing immunosuppressive cytokines and apoptosis resistance |
| 18763053 (TLR4) | both mRNA and protein levels of TLR4 and TLR9 were strongly expressed in lung cancer tissue; the expression level of TLR4 correlated with malignancy of lung cancer |
| 24889928 (TLR4) | These data suggest that TLR4 plays an important role in tumorigenic properties of human non-small cell lung cancer |
| 26063617 (TLR4) | demonstrate that the effect of TP53 mutational status on TLR4 activity may extend to ovarian, colon, and lung cancers, among others, suggesting that the viability of TLR4 as a therapeutic target depends on TP53 status in many different tumor types |
| 26299699 (TLR4) | No correlation was found between rs4986790 polymorphism and lung cancer, while a correlation between rs4986791 and lung cancer has been determined and found to be associated with lung cancer risk. |
| 27223258 (TLR4) | Toll-like receptor 4 may have a role in non-small cell lung cancer |
| 27286259 (TLR4) | essential role of TLR4/ROS/miR-21 pathway in LPS-induced outgrowth of primary human lung cancer |
| 27545207 (TLR4) | Methicillin-resistant Staphylococcus aureus infection can enhance non small cell lung cancer cell metastasis by up-regulating TLR4/MyD88 signaling. |
| 29343453 (TLR4) | The immunoenhancement effect of PSP against lung cancer is mediated by TLR4-MAPK/NF-kappaB signaling pathways |
| 29927028 (TLR4) | Resistin promoted lung adenocarcinoma metastasis through the TLR4/Src/EGFR/PI3K/NF-kappaB pathway. |
| 31382038 (TLR4) | Gram-Negative Pneumonia Augments Non-Small Cell lung cancer Metastasis through Host Toll-like Receptor 4 Activation. |
| 32494918 (TLR4) | Bone marrow adipocytes enhance osteolytic bone destruction by activating 1q21.3(S100A7/8/9-IL6R)-TLR4 pathway in lung cancer. |
| 16706798 (Tlr4) | TLR2 knockout and TLR4 knockout mice produced interleukin-1beta, IL-6, IL-12p40 and tumor necrosis factor-alpha in sera and cleared this Cryptococcus neoformans from infected lungs. |
| 19925653 (Tlr4) | transcriptomic study determined the protective effect of TLR4 in lung carcinogenesis inhibition of multiple pathways |
| 22890596 (Tlr4) | Loss of TLR4 is associated with tumor progression and lung metastasis in breast cancer. |
| 24211974 (Tlr4) | activation of TLR4 signaling pathway in lung cancer cells may be involved in tumor escape and progression by promoting the expression of TGF-beta1 and IL-10 and tumor cells migration |