| Gene ID | 7099 |
| Symbol | TLR4 |
| Synonymous | ARMD10|CD284|TLR-4|TOLL |
| Full name | toll-like receptor 4 |
| Gene description | hToll|homolog of Drosophila toll |
| Cytoband | 9q33.1 |
| Gene type | protein-coding |
| Synonymous | MIM:603030; HGNC:HGNC:11850; Ensembl:ENSG00000136869; HPRD:04325; Vega:OTTHUMG00000021046 |
Pathways and Diseases | Detail |
|---|---|
Pathway | Chagas disease;KEGG PATHWAY;hsa05142 |
Pathway | Pathogenic Escherichia coli infection;KEGG PATHWAY;hsa05130 |
Pathway | Amoebiasis;KEGG PATHWAY;hsa05146 |
Pathway | Malaria;KEGG PATHWAY;hsa05144 |
Pathway | inactivation of gsk3 by akt causes accumulation of b-catenin in alveolar macrophages;PID BioCarta;100152 |
Pathway | Toll-like receptor signaling pathway;KEGG PATHWAY;hsa04620 |
Pathway | toll-like receptor pathway;PID BioCarta;100013 |
Pathway | Signaling in Immune system;Reactome;REACT:6900 |
Pathway | Endogenous TLR signaling;PID Curated;200177 |
Pathway | Leishmaniasis;KEGG PATHWAY;hsa05140 |
Pathway | nf-kb signaling pathway;PID BioCarta;100097 |
Pathway | Toll receptor signaling pathway;PANTHER;P00054 |
Pathway | Toxoplasmosis;KEGG PATHWAY;hsa05145 |
Pathway | Phagosome;KEGG PATHWAY;hsa04145 |
Disease | Adenocarcinoma;FunDO |
Disease | inflammatory bowel disease;GAD |
Disease | Premature birth;FunDO |
Disease | Polyarthritis;FunDO |
Disease | Nasopharyngeal cancer;FunDO |
Disease | Legionnaire's disease;GAD |
Disease | Influenza;FunDO |
Disease | IMMUNE;GAD |
Disease | meningococcal disease;GAD |
Disease | Mycoses;FunDO |
Disease | Colon cancer;FunDO |
Disease | lipopolysaccharide hyporesponsiveness;GAD |
Disease | prostate cancer;GAD |
Disease | Enteritis;FunDO |
Disease | Mycoses;GAD |
Disease | C-reactive protein;GAD |
Disease | metabolic syndrome;GAD |
Disease | myocardial infarct;GAD |
Disease | Intermediate coronary syndrome;FunDO |
Disease | Neuroblastoma;FunDO |
Disease | Oral cancer;FunDO |
Disease | Lung cancer;FunDO |
Disease | Melanoma;FunDO |
Disease | Gastritis;FunDO |
Disease | sarcoidosis;GAD |
Disease | esophageal cancer noncardia gastric carcinoma stomach cancer;GAD |
Disease | Macular degeneration, age-related, 10;OMIM |
Disease | Ulcerative colitis;FunDO |
Disease | Helicobacter infection;FunDO |
Disease | Hypercholesterolemia;FunDO |
Disease | Communicable disease;FunDO |
Disease | stroke, ischemic;GAD |
Disease | Pancreatitis;FunDO |
Disease | atherosclerosis, coronary;GAD |
Disease | kidney transplant;GAD |
Disease | diabetes, neurological manifestations;GAD |
Disease | Systemic infection;FunDO |
Disease | sepsis;GAD |
Disease | malaria;GAD |
Disease | Crohn's disease;GAD |
Disease | FEV1;GAD |
Disease | shortened gestation;GAD |
Disease | Necrotizing enterocolitis;FunDO |
Disease | Behcet syndrome;FunDO |
Disease | Systemic responsiveness to lipopolysaccharide;GAD |
Disease | ulcerative colitis;GAD |
Disease | Meningococcal Infections;GAD |
Disease | HEMATOLOGICAL;GAD |
Disease | Macular degeneration;FunDO |
Disease | vaginal micro-flora;GAD |
Disease | Cytomegalovirus infection;FunDO |
Disease | Asthma;FunDO |
Disease | Atherosclerosis;FunDO |
Disease | Acute Coronary Syndrome;GAD |
Disease | Prostate cancer;FunDO |
Disease | Mycosis fungoides;FunDO |
Disease | Anemia;FunDO |
Disease | graft-versus-host disease;GAD |
Disease | METABOLIC;GAD |
Disease | colorectal cancer;GAD |
Disease | Pre-Eclampsia;FunDO |
Disease | diabetes, type 2;GAD |
Disease | CARDIOVASCULAR;GAD |
Disease | acute pancreatitis;GAD |
Disease | Brucellosis;FunDO |
Disease | Chronic obstructive airway disease;FunDO |
Disease | REPRODUCTION;GAD |
Disease | Celiac disease;FunDO |
Disease | Congenital abnormality;FunDO |
Disease | Atherosclerosis;GAD |
Disease | Porcine reproductive and respiratory syndrome;FunDO |
Disease | Periodontitis;FunDO |
Disease | Hepatitis C;FunDO |
Disease | Endotoxin hyporesponsiveness;OMIM |
Disease | Stomach cancer;FunDO |
Disease | nasopharyngeal cancer;GAD |
Disease | Embryoma;FunDO |
Disease | pancreatic necrosis pancreatitis, acute;GAD |
Disease | Cystic fibrosis;FunDO |
Disease | Colorectal cancer, susceptibility to;OMIM |
Disease | Asthma;GAD |
Disease | periodontitis;GAD |
Disease | Stroke;FunDO |
Disease | Alzheimer's disease;FunDO |
Disease | Septic shock;GAD |
Disease | Autoimmune disease;FunDO |
Disease | Primary biliary cirrhosis;FunDO |
Disease | Diabetes mellitus;FunDO |
Disease | respiratory syncytial virus;GAD |
Disease | systemic inflammatory hyporesponsiveness;GAD |
Disease | Multiple sclerosis;FunDO |
Disease | CANCER;GAD |
Disease | endotoxin hyporesponsiveness;GAD |
Disease | Kidney failure;FunDO |
Disease | Heart failure;FunDO |
Disease | Pituitary tumor;FunDO |
Disease | INFECTION;GAD |
Disease | RENAL;GAD |
Sequence Information | |
|---|---|
Nucleotide Sequence | >7099 : length: 5781 TAGCTTCCTCTTGCTGTTTCTTTAGCCACTGGTCTGCAGGCGTTTTCTTCTTCTAACTTCCTCTCCTGTGACAAAAGAGATAACTATTAGAGAAACAAAAGTCCAGAATGCTAAGGTTGC CGCTTTCACTTCCTCTCACCCTTTAGCCCAGAACTGCTTTGAATACACCAATTGCTGTGGGGCGGCTCGAGGAAGAGAAGACACCAGTGCCTCAGAAACTGCTCGGTCAGACGGTGATAG CGAGCCACGCATTCACAGGGCCACTGCTGCTCACAGAAGCAGTGAGGATGATGCCAGGATGATGTCTGCCTCGCGCCTGGCTGGGACTCTGATCCCAGCCATGGCCTTCCTCTCCTGCGT GAGACCAGAAAGCTGGGAGCCCTGCGTGGAGACTTGGCCCTAAACCACACAGAAGAGCTGGCATGAAACCCAGAGCTTTCAGACTCCGGAGCCTCAGCCCTTCACCCCGATTCCATTGCT TCTTGCTAAATGCTGCCGTTTTATCACGGAGGTGGTTCCTAATATTACTTATCAATGCATGGAGCTGAATTTCTACAAAATCCCCGACAACCTCCCCTTCTCAACCAAGAACCTGGACCT GAGCTTTAATCCCCTGAGGCATTTAGGCAGCTATAGCTTCTTCAGTTTCCCAGAACTGCAGGTGCTGGATTTATCCAGGTGTGAAATCCAGACAATTGAAGATGGGGCATATCAGAGCCT AAGCCACCTCTCTACCTTAATATTGACAGGAAACCCCATCCAGAGTTTAGCCCTGGGAGCCTTTTCTGGACTATCAAGTTTACAGAAGCTGGTGGCTGTGGAGACAAATCTAGCATCTCT AGAGAACTTCCCCATTGGACATCTCAAAACTTTGAAAGAACTTAATGTGGCTCACAATCTTATCCAATCTTTCAAATTACCTGAGTATTTTTCTAATCTGACCAATCTAGAGCACTTGGA CCTTTCCAGCAACAAGATTCAAAGTATTTATTGCACAGACTTGCGGGTTCTACATCAAATGCCCCTACTCAATCTCTCTTTAGACCTGTCCCTGAACCCTATGAACTTTATCCAACCAGG TGCATTTAAAGAAATTAGGCTTCATAAGCTGACTTTAAGAAATAATTTTGATAGTTTAAATGTAATGAAAACTTGTATTCAAGGTCTGGCTGGTTTAGAAGTCCATCGTTTGGTTCTGGG AGAATTTAGAAATGAAGGAAACTTGGAAAAGTTTGACAAATCTGCTCTAGAGGGCCTGTGCAATTTGACCATTGAAGAATTCCGATTAGCATACTTAGACTACTACCTCGATGATATTAT TGACTTATTTAATTGTTTGACAAATGTTTCTTCATTTTCCCTGGTGAGTGTGACTATTGAAAGGGTAAAAGACTTTTCTTATAATTTCGGATGGCAACATTTAGAATTAGTTAACTGTAA ATTTGGACAGTTTCCCACATTGAAACTCAAATCTCTCAAAAGGCTTACTTTCACTTCCAACAAAGGTGGGAATGCTTTTTCAGAAGTTGATCTACCAAGCCTTGAGTTTCTAGATCTCAG TAGAAATGGCTTGAGTTTCAAAGGTTGCTGTTCTCAAAGTGATTTTGGGACAACCAGCCTAAAGTATTTAGATCTGAGCTTCAATGGTGTTATTACCATGAGTTCAAACTTCTTGGGCTT AGAACAACTAGAACATCTGGATTTCCAGCATTCCAATTTGAAACAAATGAGTGAGTTTTCAGTATTCCTATCACTCAGAAACCTCATTTACCTTGACATTTCTCATACTCACACCAGAGT TGCTTTCAATGGCATCTTCAATGGCTTGTCCAGTCTCGAAGTCTTGAAAATGGCTGGCAATTCTTTCCAGGAAAACTTCCTTCCAGATATCTTCACAGAGCTGAGAAACTTGACCTTCCT GGACCTCTCTCAGTGTCAACTGGAGCAGTTGTCTCCAACAGCATTTAACTCACTCTCCAGTCTTCAGGTACTAAATATGAGCCACAACAACTTCTTTTCATTGGATACGTTTCCTTATAA GTGTCTGAACTCCCTCCAGGTTCTTGATTACAGTCTCAATCACATAATGACTTCCAAAAAACAGGAACTACAGCATTTTCCAAGTAGTCTAGCTTTCTTAAATCTTACTCAGAATGACTT TGCTTGTACTTGTGAACACCAGAGTTTCCTGCAATGGATCAAGGACCAGAGGCAGCTCTTGGTGGAAGTTGAACGAATGGAATGTGCAACACCTTCAGATAAGCAGGGCATGCCTGTGCT GAGTTTGAATATCACCTGTCAGATGAATAAGACCATCATTGGTGTGTCGGTCCTCAGTGTGCTTGTAGTATCTGTTGTAGCAGTTCTGGTCTATAAGTTCTATTTTCACCTGATGCTTCT TGCTGGCTGCATAAAGTATGGTAGAGGTGAAAACATCTATGATGCCTTTGTTATCTACTCAAGCCAGGATGAGGACTGGGTAAGGAATGAGCTAGTAAAGAATTTAGAAGAAGGGGTGCC TCCATTTCAGCTCTGCCTTCACTACAGAGACTTTATTCCCGGTGTGGCCATTGCTGCCAACATCATCCATGAAGGTTTCCATAAAAGCCGAAAGGTGATTGTTGTGGTGTCCCAGCACTT CATCCAGAGCCGCTGGTGTATCTTTGAATATGAGATTGCTCAGACCTGGCAGTTTCTGAGCAGTCGTGCTGGTATCATCTTCATTGTCCTGCAGAAGGTGGAGAAGACCCTGCTCAGGCA GCAGGTGGAGCTGTACCGCCTTCTCAGCAGGAACACTTACCTGGAGTGGGAGGACAGTGTCCTGGGGCGGCACATCTTCTGGAGACGACTCAGAAAAGCCCTGCTGGATGGTAAATCATG GAATCCAGAAGGAACAGTGGGTACAGGATGCAATTGGCAGGAAGCAACATCTATCTGAAGAGGAAAAATAAAAACCTCCTGAGGCATTTCTTGCCCAGCTGGGTCCAACACTTGTTCAGT TAATAAGTATTAAATGCTGCCACATGTCAGGCCTTATGCTAAGGGTGAGTAATTCCATGGTGCACTAGATATGCAGGGCTGCTAATCTCAAGGAGCTTCCAGTGCAGAGGGAATAAATGC TAGACTAAAATACAGAGTCTTCCAGGTGGGCATTTCAACCAACTCAGTCAAGGAACCCATGACAAAGAAAGTCATTTCAACTCTTACCTCATCAAGTTGAATAAAGACAGAGAAAACAGA AAGAGACATTGTTCTTTTCCTGAGTCTTTTGAATGGAAATTGTATTATGTTATAGCCATCATAAAACCATTTTGGTAGTTTTGACTGAACTGGGTGTTCACTTTTTCCTTTTTGATTGAA TACAATTTAAATTCTACTTGATGACTGCAGTCGTCAAGGGGCTCCTGATGCAAGATGCCCCTTCCATTTTAAGTCTGTCTCCTTACAGAGGTTAAAGTCTAGTGGCTAATTCCTAAGGAA ACCTGATTAACACATGCTCACAACCATCCTGGTCATTCTCGAGCATGTTCTATTTTTTAACTAATCACCCCTGATATATTTTTATTTTTATATATCCAGTTTTCATTTTTTTACGTCTTG CCTATAAGCTAATATCATAAATAAGGTTGTTTAAGACGTGCTTCAAATATCCATATTAACCACTATTTTTCAAGGAAGTATGGAAAAGTACACTCTGTCACTTTGTCACTCGATGTCATT CCAAAGTTATTGCCTACTAAGTAATGACTGTCATGAAAGCAGCATTGAAATAATTTGTTTAAAGGGGGCACTCTTTTAAACGGGAAGAAAATTTCCGCTTCCTGGTCTTATCATGGACAA TTTGGGCTAGAGGCAGGAAGGAAGTGGGATGACCTCAGGAGGTCACCTTTTCTTGATTCCAGAAACATATGGGCTGATAAACCCGGGGTGACCTCATGAAATGAGTTGCAGCAGAAGTTT ATTTTTTTCAGAACAAGTGATGTTTGATGGACCTCTGAATCTCTTTAGGGAGACACAGATGGCTGGGATCCCTCCCCTGTACCCTTCTCACTGCCAGGAGAACTACGTGTGAAGGTATTC AAGGCAGGGAGTATACATTGCTGTTTCCTGTTGGGCAATGCTCCTTGACCACATTTTGGGAAGAGTGGATGTTATCATTGAGAAAACAATGTGTCTGGAATTAATGGGGTTCTTATAAAG AAGGTTCCCAGAAAAGAATGTTCATCCAGCCTCCTCAGAAACAGAACATTCAAGAAAAGGACAATCAGGATGTCATCAGGGAAATGAAAATAAAAACCACAATGAGATATCACCTTATAC CAGGTAGAATGGCTACTATAAAAAAATGAAGTGTCATCAAGGATATAGAGAAATTGGAACCCTTCTTCACTGCTGGAGGGAATGGAAAATGGTGTAGCCGTTATGAAAAACAGTACGGAG GTTTCTCAAAAATTAAAAATAGAACTGCTATATGATCCAGCAATCTCACTTCTGTATATATACCCAAAATAATTGAAATCAGAATTTCAAGAAAATATTTACACTCCCATGTTCATTGTG GCACTCTTCACAATCACTGTTTCCAAAGTTATGGAAACAACCCAAATTTCCATTGAAAAATAAATGGACAAAGAAAATGTGCATATACGTACAATGGGATATTATTCAGCCTAAAAAAAG GGGGAATCCTGTTATTTATGACAACATGAATAAACCCGGAGGCCATTATGCTATGTAAAATGAGCAAGTAACAGAAAGACAAATACTGCCTGATTTCATTTATATGAGGTTCTAAAATAG TCAAACTCATAGAAGCAGAGAATAGAACAGTGGTTCCTAGGGAAAAGGAGGAAGGGAGAAATGAGGAAATAGGGAGTTGTCTAATTGGTATAAAATTATAGTATGCAAGATGAATTAGCT CTAAAGATCAGCTGTATAGCAGAGTTCGTATAATGAACAATACTGTATTATGCACTTAACATTTTGTTAAGAGGGTACCTCTCATGTTAAGTGTTCTTACCATATACATATACACAAGGA AGCTTTTGGAGGTGATGGATATATTTATTACCTTGATTGTGGTGATGGTTTGACAGGTATGTGACTATGTCTAAACTCATCAAATTGTATACATTAAATATATGCAGTTTTATAATATCA ATTATGTCTGAATGAAGCTATAAAAAAGAAAAGACAACAAAATTCAGTTGTCAAAACTGGAAATATGACCACAGTCAGAAGTGTTTGTTACTGAGTGTTTCAGAGTGTGTTTGGTTTGAG CAGGTCTAGGGTGATTGAACATCCCTGGGTGTGTTTCCATGTCTCATGTACTAGTGAAAGTAGATGTGTGCATTTGTGCACATATCCCTATGTATCCCTATCAGGGCTGTGTGTATTTGA AAGTGTGTGTGTCCGCATGATCATATCTGTATAGAAGAGAGTGTGATTATATTTCTTGAAGAATACATCCATTTGAAATGGATGTCTATGGCTGTTTGAGATGAGTTCTCTACTCTTGTG CTTGTACAGTAGTCTCCCCTTATCCCTTATGCTTGGTGGATACGTTCTTAGACCCCAAGTGGATCTCTGAGACCGCAGATGGTACCAAACCTCATATATGCAATATTTTTTCCTATACAT AAATACCTAAGATAAAGTTCATCTTCTGAATTAGGCACAGTAAGAGATTAACAATAACTAACAATAAAATTGAATAGTTATAATAATATATTGTAATAAAAGTTATGTGAATGTGATCTC TTTCTTTCTCTCTCTCAAAAT |
Protein Sequence | >7099 : length: 839 MMSASRLAGTLIPAMAFLSCVRPESWEPCVEVVPNITYQCMELNFYKIPDNLPFSTKNLDLSFNPLRHLGSYSFFSFPELQVLDLSRCEIQTIEDGAYQSLSHLSTLILTGNPIQSLALG AFSGLSSLQKLVAVETNLASLENFPIGHLKTLKELNVAHNLIQSFKLPEYFSNLTNLEHLDLSSNKIQSIYCTDLRVLHQMPLLNLSLDLSLNPMNFIQPGAFKEIRLHKLTLRNNFDSL NVMKTCIQGLAGLEVHRLVLGEFRNEGNLEKFDKSALEGLCNLTIEEFRLAYLDYYLDDIIDLFNCLTNVSSFSLVSVTIERVKDFSYNFGWQHLELVNCKFGQFPTLKLKSLKRLTFTS NKGGNAFSEVDLPSLEFLDLSRNGLSFKGCCSQSDFGTTSLKYLDLSFNGVITMSSNFLGLEQLEHLDFQHSNLKQMSEFSVFLSLRNLIYLDISHTHTRVAFNGIFNGLSSLEVLKMAG NSFQENFLPDIFTELRNLTFLDLSQCQLEQLSPTAFNSLSSLQVLNMSHNNFFSLDTFPYKCLNSLQVLDYSLNHIMTSKKQELQHFPSSLAFLNLTQNDFACTCEHQSFLQWIKDQRQL LVEVERMECATPSDKQGMPVLSLNITCQMNKTIIGVSVLSVLVVSVVAVLVYKFYFHLMLLAGCIKYGRGENIYDAFVIYSSQDEDWVRNELVKNLEEGVPPFQLCLHYRDFIPGVAIAA NIIHEGFHKSRKVIVVVSQHFIQSRWCIFEYEIAQTWQFLSSRAGIIFIVLQKVEKTLLRQQVELYRLLSRNTYLEWEDSVLGRHIFWRRLRKALLDGKSWNPEGTVGTGCNWQEATSI |