down-regulation of Claudin-7 and overexpression of Slug in lung squamous cell carcinoma and adenocarcinoma

High SLUG expression is associated with lung cancer growth and metastasis.

ANGPTL1 represses lung cancer cell motility by abrogating the expression of the epithelial mesenchymal transformation mediator SLUG.

Slug mediates an aggressive phenotype including enhanced migration activity, anoikis suppression, and tumor growth, but increases sensitivity to tubulin-binding agents via the downregulation of betaIII and betaIVa-tubulin in lung cancer cells.

Loss of slug expression is associated with breast and lung cancer.

Slug influences growth of lung squamous cell carcinomas and has an independent prognostic value in this tumor type.

Data show that patients with high MDA-9/Syntenin and high Slug expressions were associated with poor overall survival compared to those with low expression in lung adenocarcinomas.

High SLUG expression is associated with lung metastasis in ovarian cancer.

overexpression of miR-218 in H1299 increased chemosensitivity of cells to cisplatin treatment through suppression of Slug and ZEB2. These findings highlight an important role of miR-218 in the regulation of EMT-related traits and metastasis of lung cancer in part by modulation of Slug/ZEB2 signaling, and provide a potential therapeutic strategy by targeting miR-218 in lung cancer.

miR-137 is a Slug-induced miRNA that relays the pro-metastatic effects of Slug by targeting TFAP2C in non-small cell lung cancer cells.

reduction of Alex3 correlates with the development of non-small cell lung cancer and predicts adverse clinical outcome of non-small cell lung cancer patients. The effect of Alex3 on inhibiting invasion and migration may attribute to upregulation of E-cadherin expression through AKT-Slug pathway inactivation.

NatD-mediated acetylation of histone H4 serine 1 competes with phosphorylation by CK2alpha at the same residue, leading to the upregulation of Slug and lung cancer progression.

High SNAI2 expression is associated with epithelial-to-mesenchymal transition in lung cancer.

Authors found that PAR2 is highly expressed in several lung adenocarcinoma cell lines. In two lung adenocarcinoma cell lines, CL1-5 and H1299 cells, activation of PAR2 induces migration and Slug-mediated EMT.

miR5845p also inhibited the expression of MMP4 and Slug, which are involved in tumor invasion and metastasis. Taken together, these results indicated that the miR5845p/MMP14 axis may serve as an anticancer target in the treatment of nonsmallcell lung cancer patients.

Overexpression of Snail2 enhanced the migration and invasion ability in lung carcinoma, whereas G9a and Histone Deacetylase inhibition significantly reversed this effect.

C/EBPdelta-Slug-Lox1 axis promotes metastasis of lung adenocarcinoma via oxLDL uptake.

Fucoidan increased the sensitivity to gefitinib in lung cancer cells correlates with reduction of TGFbeta-mediated Slug expression.

DNA methylation maintains the CLDN1-EPHB6-SLUG axis to enhance chemotherapeutic efficacy and inhibit lung cancer progression.