| slug(h) --> BRCA2(h) (DNA binding).
|
slug(h) --26S proteasome(h)--> protein remnants (degradation)
|
mdm2(h) + p53(h) + slug(h) <==> mdm2(h):p53(h):slug(h) (binding)
|
SLUG(h) --> slug(h) (expression).
|
mdm2(h) --/ slug(h) (decrease of abundance)
|
p53(h) --/ slug(h) (decrease of abundance)
|
slug(h) + mdm2(h) <==> slug(h):mdm2(h) (binding)
|
slug(h) + n ubiquitin(h) --mdm2(h)--> slug(h){ub(n)} (ubiquitination)
|
slug(h) + p53(h) <==> slug(h):p53(h) (binding)
|
mdm2(h) + slug(h) + p53(h) <==> mdm2(h):slug(h):p53(h) (binding)
|
slug(h) --/ HPGD(h) (transrepression)
|
SLUG(h) --> slug(h) (expression).
|
p53(h) --/ slug(h) (decrease of abundance)
|
