Skp2 mRNA expression level was high in squamous cell carcinomas of the lung and was inversely related with the p27(Kip1) protein level

Skp2 protein expression is a significant independent poor prognostic marler in non-small cell lung carcinoma.

Amplification and overexpression of SKP2 are associated with metastasis of non-small-cell lung cancers to lymph nodes.

SKP2 plays an oncogenic role in lung cancer and that SKP2 silencing may be useful in the treatment of lung cancer

Skp2 expression might play an important role in the development and progression in non-small cell lung cancer

Overexpression of Skp2 is associated with neuroendocrine lung tumors

of Skp2 is a critical step for the suppression of cell proliferation by Tubocapsanolide A because ectoexpression of Skp2 effectively reversed Tubocapsanolide A-induced p27 up-regulation and growth inhibition in human lung cancer cells

Data suggest that mternally expressed gene 3 (Meg3) long non-coding RNA and microRNA miR-3163 may coordinate suppression of translation of S-phase kinase associated protein 2 (Skp2) mRNA in non-small cell lung cancer (NSCLC) cells to inhibit cell growth.

p27 and its cognate ubiquitin ligases, Skp2/KPC/Pirh2, are specifically involved in determining the clinical profiles of lung carcinomas.

High SKP2 expression is associated with lung cancer.

High SKP2 expression is associated with Non-Small Cell lung cancer.

MiR-339 targets the 3'-untranslated region of Skp2 mRNA to depress the proliferation of lung cancer cells.

5-FU enriches the cancer stem cells in lung adenocarcinoma cells via increasing Fbxw7 and decreasing Skp2 expression, followed by downregulation of c-myc and upregulation of p27, which switches cells to quiescence.

Results describe a previously unrecognized, SCFskp2-independent role for the control of p27 mRNA abundance in the development of non-small cell lung cancers.