CUB-domain-containing protein 1 (CDCP1), is identified as an Src family kinases-binding phosphoprotein associated with the anchorage independence of human lung adenocarcinoma.

CDCP1 expression level is a useful marker for prediction of patients with lung adenocarcinoma

Data show that the signaling events that accompany the CDCP1 tyrosine phosphorylation observed in cell lines and lung tumors may explain how the CDCP1/SFK complex regulates motility and adhesion.

strongly expressed in tumors derived from lung, colon, ovary, or kidney. for a full transformation capacity, the intact amino- and carboxy-termini of CDCP1 are essential.

In migrating cancer stem cells isolated from primary human colorectal cancers, CD110(+) and CDCP1(+) subpopulations mediate organ-specific lung and liver metastasis.

The aim of this study was to examine whether activation of Trask may be potentially important in brain metastasis of lung cancers, the commonest site of organ spread and producing the deadliest consequences.

ADAM9 enhances CDCP1 protein expression by suppressing miR-218 for lung tumor metastasis

These results revealed that ADAM9 down-regulates miR-1 via activating EGFR signaling pathways, which in turn enhances CDCP1 expression to promote lung cancer progression.