lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	64866
Symbol	CDCP1
Synonymous	CD318\|SIMA135\|TRASK
Full name	CUB domain containing protein 1
Gene description	CUB domain-containing protein 1\|membrane glycoprotein gp140\|subtractive immunization M plus HEp3-associated 135 kDa protein\|transmembrane and associated with src kinases
Cytoband	3p21.31
Gene type	protein-coding
Synonymous	MIM:611735; HGNC:HGNC:24357; Ensembl:ENSG00000163814; HPRD:16696; Vega:OTTHUMG00000133090

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.1919T>A; p.I640N; 3:45091247-45091247	liver	carcinoma	Substitution - Missense
c.2177G>A; p.R726Q; 3:45085972-45085972	skin	malignant_melanoma	Substitution - Missense
c.1296G>T; p.V432V; 3:45093608-45093608	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.2488G>T; p.E830*; 3:45085661-45085661	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.1125C>T; p.F375F; 3:45095468-45095468	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.2339G>A; p.C780Y; 3:45085810-45085810	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1275G>A; p.R425R; 3:45093629-45093629	skin	malignant_melanoma	Substitution - coding silent
c.1275G>A; p.R425R; 3:45093629-45093629	skin	malignant_melanoma	Substitution - coding silent
c.2307G>A; p.M769I; 3:45085842-45085842	skin; neck	malignant_melanoma	Substitution - Missense
c.1025-7G>A; p.?; 3:45095575-45095575	liver	carcinoma	Unknown
c.2130C>T; p.N710N; 3:45086019-45086019	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.674C>T; p.S225F; 3:45110823-45110823	skin	malignant_melanoma	Substitution - Missense
c.473G>A; p.G158E; 3:45112265-45112265	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1498C>T; p.P500S; 3:45093406-45093406	skin	malignant_melanoma	Substitution - Missense
c.571G>T; p.G191*; 3:45112167-45112167	stomach	carcinoma; adenocarcinoma	Substitution - Nonsense
c.747C>T; p.L249L; 3:45110750-45110750	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1760G>T; p.C587F; 3:45091406-45091406	breast	carcinoma	Substitution - Missense
c.1572C>T; p.F524F; 3:45093332-45093332	skin	malignant_melanoma	Substitution - coding silent
c.341C>T; p.S114L; 3:45112397-45112397	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.492C>T; p.S164S; 3:45112246-45112246	thyroid	carcinoma	Substitution - coding silent
c.2096A>G; p.N699S; 3:45086053-45086053	skin	malignant_melanoma	Substitution - Missense
c.2148G>A; p.P716P; 3:45086001-45086001	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.1084C>T; p.R362W; 3:45095509-45095509	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1627G>A; p.E543K; 3:45093277-45093277	skin; extremity	malignant_melanoma	Substitution - Missense
c.794C>T; p.S265F; 3:45110703-45110703	skin	malignant_melanoma	Substitution - Missense
c.1756G>A; p.A586T; 3:45091410-45091410	skin; leg	malignant_melanoma; superficial_spreading	Substitution - Missense
c.979C>T; p.R327W; 3:45110518-45110518	skin; trunk	malignant_melanoma	Substitution - Missense
c.2487G>T; p.Q829H; 3:45085662-45085662	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1315C>T; p.L439L; 3:45093589-45093589	thyroid	carcinoma	Substitution - coding silent
c.384T>C; p.D128D; 3:45112354-45112354	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.916G>A; p.A306T; 3:45110581-45110581	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1844C>T; p.A615V; 3:45091322-45091322	skin	malignant_melanoma	Substitution - Missense
c.269T>C; p.V90A; 3:45118435-45118435	breast	carcinoma	Substitution - Missense
c.742G>A; p.E248K; 3:45110755-45110755	cervix	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1841G>T; p.R614L; 3:45091325-45091325	skin	malignant_melanoma	Substitution - Missense
c.522C>T; p.I174I; 3:45112216-45112216	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.827G>A; p.R276K; 3:45110670-45110670	skin	malignant_melanoma	Substitution - Missense
c.534C>T; p.C178C; 3:45112204-45112204	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1684C>T; p.P562S; 3:45091482-45091482	skin	malignant_melanoma	Substitution - Missense
c.170A>G; p.Y57C; 3:45118534-45118534	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1586C>T; p.S529F; 3:45093318-45093318	skin	malignant_melanoma	Substitution - Missense
c.2321C>T; p.P774L; 3:45085828-45085828	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.479C>T; p.T160I; 3:45112259-45112259	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.599G>A; p.W200*; 3:45112139-45112139	skin	malignant_melanoma	Substitution - Nonsense
c.1738G>A; p.V580M; 3:45091428-45091428	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1089C>T; p.P363P; 3:45095504-45095504	skin	malignant_melanoma	Substitution - coding silent
c.2173G>A; p.G725R; 3:45085976-45085976	skin	malignant_melanoma	Substitution - Missense
c.1581G>A; p.E527E; 3:45093323-45093323	skin	malignant_melanoma	Substitution - coding silent
c.1141C>T; p.R381W; 3:45095452-45095452	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1500G>A; p.P500P; 3:45093404-45093404	stomach	adenocarcinoma	Substitution - coding silent
c.1416C>T; p.H472H; 3:45093488-45093488	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1417G>A; p.E473K; 3:45093487-45093487	skin	malignant_melanoma	Substitution - Missense
c.694T>C; p.S232P; 3:45110803-45110803	skin	malignant_melanoma	Substitution - Missense
c.1922C>T; p.S641F; 3:45091244-45091244	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2165T>G; p.F722C; 3:45085984-45085984	skin	malignant_melanoma	Substitution - Missense
c.258G>A; p.E86E; 3:45118446-45118446	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.921G>T; p.G307G; 3:45110576-45110576	breast	carcinoma	Substitution - coding silent
c.1623C>T; p.F541F; 3:45093281-45093281	breast	carcinoma	Substitution - coding silent
c.779T>A; p.L260Q; 3:45110718-45110718	skin	malignant_melanoma	Substitution - Missense
c.502G>A; p.D168N; 3:45112236-45112236	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.502G>A; p.D168N; 3:45112236-45112236	skin	malignant_melanoma	Substitution - Missense
c.1722G>T; p.V574V; 3:45091444-45091444	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.2457G>T; p.K819N; 3:45085692-45085692	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.890T>C; p.L297P; 3:45110607-45110607	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2181G>A; p.K727K; 3:45085968-45085968	skin	malignant_melanoma	Substitution - coding silent
c.31G>T; p.A11S; 3:45146257-45146257	liver	carcinoma	Substitution - Missense
c.31G>T; p.A11S; 3:45146257-45146257	liver	carcinoma	Substitution - Missense
c.2062A>T; p.I688F; 3:45089073-45089073	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1747G>C; p.D583H; 3:45091419-45091419	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1162A>G; p.T388A; 3:45095431-45095431	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2395_2402delCCTGAGTC; p.P799fs*1; 3:45085747-45085754	breast	carcinoma	Deletion - Frameshift
c.839G>A; p.R280Q; 3:45110658-45110658	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1595G>A; p.G532D; 3:45093309-45093309	skin	malignant_melanoma	Substitution - Missense
c.524G>A; p.G175E; 3:45112214-45112214	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1038G>A; p.V346V; 3:45095555-45095555	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.401G>A; p.S134N; 3:45112337-45112337	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.2146C>G; p.P716A; 3:45086003-45086003	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.2404G>C; p.E802Q; 3:45085745-45085745	breast	carcinoma	Substitution - Missense
c.2210T>C; p.I737T; 3:45085939-45085939	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2348C>T; p.A783V; 3:45085801-45085801	skin	malignant_melanoma	Substitution - Missense
c.2107G>A; p.A703T; 3:45086042-45086042	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2146C>T; p.P716S; 3:45086003-45086003	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2146C>T; p.P716S; 3:45086003-45086003	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1964T>A; p.F655Y; 3:45091202-45091202	skin	malignant_melanoma	Substitution - Missense
c.2362T>C; p.L788L; 3:45085787-45085787	skin	malignant_melanoma	Substitution - coding silent
c.848A>G; p.Y283C; 3:45110649-45110649	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.703C>T; p.L235L; 3:45110794-45110794	skin	malignant_melanoma	Substitution - coding silent
c.2322C>T; p.P774P; 3:45085827-45085827	skin	malignant_melanoma	Substitution - coding silent
c.2054G>A; p.G685E; 3:45089081-45089081	skin	malignant_melanoma	Substitution - Missense
c.2009T>C; p.L670P; 3:45089126-45089126	liver	carcinoma	Substitution - Missense
c.2212G>A; p.E738K; 3:45085937-45085937	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.2009T>C; p.L670P; 3:45089126-45089126	liver	carcinoma	Substitution - Missense
c.1809C>T; p.R603R; 3:45091357-45091357	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.765C>T; p.V255V; 3:45110732-45110732	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.1809C>T; p.R603R; 3:45091357-45091357	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.741T>G; p.D247E; 3:45110756-45110756	skin	malignant_melanoma	Substitution - Missense
c.101T>C; p.L34P; 3:45118603-45118603	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2485C>G; p.Q829E; 3:45085664-45085664	pancreas	carcinoma	Substitution - Missense
c.1569C>A; p.S523R; 3:45093335-45093335	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Missense
c.1569C>A; p.S523R; 3:45093335-45093335	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Missense
c.140G>A; p.G47E; 3:45118564-45118564	bone; extraskeletal	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.1816A>G; p.M606V; 3:45091350-45091350	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1866C>T; p.D622D; 3:45091300-45091300	NS	NS	Substitution - coding silent
c.1866C>T; p.D622D; 3:45091300-45091300	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1486G>C; p.G496R; 3:45093418-45093418	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1548C>A; p.T516T; 3:45093356-45093356	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.2193C>T; p.S731S; 3:45085956-45085956	skin	malignant_melanoma	Substitution - coding silent
c.1975C>T; p.L659F; 3:45091191-45091191	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1421A>C; p.K474T; 3:45093483-45093483	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.2020G>A; p.V674M; 3:45089115-45089115	central_nervous_system; medulla	primitive_neuroectodermal_tumour-medulloblastoma; large_cell	Substitution - Missense
c.902A>T; p.Q301L; 3:45110595-45110595	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.511G>A; p.V171M; 3:45112227-45112227	thyroid	carcinoma; anaplastic_carcinoma	Substitution - Missense
c.1077C>T; p.I359I; 3:45095516-45095516	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.324G>T; p.E108D; 3:45112414-45112414	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2043G>C; p.L681L; 3:45089092-45089092	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.622G>A; p.G208S; 3:45112116-45112116	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1818G>A; p.M606I; 3:45091348-45091348	skin	malignant_melanoma	Substitution - Missense
c.523G>A; p.G175R; 3:45112215-45112215	skin	malignant_melanoma	Substitution - Missense
c.2082G>A; p.K694K; 3:45086067-45086067	skin	malignant_melanoma	Substitution - coding silent
c.2429A>G; p.H810R; 3:45085720-45085720	central_nervous_system; brain	glioma	Substitution - Missense
c.2384C>T; p.P795L; 3:45085765-45085765	skin	malignant_melanoma	Substitution - Missense
c.1108T>C; p.F370L; 3:45095485-45095485	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.553C>T; p.R185W; 3:45112185-45112185	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1113C>T; p.V371V; 3:45095480-45095480	skin	malignant_melanoma	Substitution - coding silent
c.921G>A; p.G307G; 3:45110576-45110576	skin	malignant_melanoma	Substitution - coding silent
c.405C>T; p.I135I; 3:45112333-45112333	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.405C>T; p.I135I; 3:45112333-45112333	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.425C>T; p.S142F; 3:45112313-45112313	skin	malignant_melanoma	Substitution - Missense
c.302C>T; p.S101L; 3:45112436-45112436	skin	malignant_melanoma	Substitution - Missense
c.2182G>A; p.D728N; 3:45085967-45085967	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1840C>T; p.R614W; 3:45091326-45091326	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1840C>T; p.R614W; 3:45091326-45091326	upper_aerodigestive_tract; mouth	carcinoma	Substitution - Missense
c.2069G>T; p.C690F; 3:45089066-45089066	liver	carcinoma	Substitution - Missense
c.2069G>T; p.C690F; 3:45089066-45089066	liver	carcinoma	Substitution - Missense
c.2069G>T; p.C690F; 3:45089066-45089066	liver	carcinoma	Substitution - Missense
c.2407_2408delAG; p.S803fs*1; 3:45085741-45085742	breast	carcinoma	Deletion - Frameshift
c.2291C>A; p.P764Q; 3:45085858-45085858	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.2390C>T; p.S797F; 3:45085759-45085759	skin	malignant_melanoma	Substitution - Missense
c.1343G>T; p.W448L; 3:45093561-45093561	adrenal_gland; adrenal_gland	adrenal_cortical_carcinoma; functioning	Substitution - Missense
c.1171T>G; p.S391A; 3:45095422-45095422	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.440G>A; p.R147K; 3:45112298-45112298	skin	malignant_melanoma	Substitution - Missense
c.362T>G; p.L121R; 3:45112376-45112376	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1810G>A; p.A604T; 3:45091356-45091356	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.235A>G; p.T79A; 3:45118469-45118469	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.533G>T; p.C178F; 3:45112205-45112205	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2112G>C; p.V704V; 3:45086037-45086037	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.2470C>A; p.P824T; 3:45085679-45085679	breast	carcinoma	Substitution - Missense
c.1553G>A; p.R518H; 3:45093351-45093351	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1878C>T; p.L626L; 3:45091288-45091288	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1330C>T; p.H444Y; 3:45093574-45093574	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.501C>T; p.I167I; 3:45112237-45112237	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.721C>T; p.P241S; 3:45110776-45110776	urinary_tract; bladder	carcinoma	Substitution - Missense
c.568G>C; p.E190Q; 3:45112170-45112170	urinary_tract; bladder	carcinoma	Substitution - Missense
c.314C>T; p.P105L; 3:45112424-45112424	skin	malignant_melanoma	Substitution - Missense
c.2412A>G; p.E804E; 3:45085737-45085737	skin	malignant_melanoma	Substitution - coding silent
c.1547C>T; p.T516I; 3:45093357-45093357	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1879C>T; p.P627S; 3:45091287-45091287	skin; arm	malignant_melanoma	Substitution - Missense
c.2000C>G; p.T667S; 3:45089135-45089135	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation