SF2/ASF and survivin expression is involved in non-small cell lung cancer progression

Identification of new splicing events regulated by the oncogenic splicing factor SRSF1 in lung cancer using novel analytical tool.

LIG1 is regulated by the oncoprotein SRSF1 and plays a relevant role in lung cancer cell proliferation and progression.

SRSF1 regulates lung cancer cell radioresistance through modulating PTPMT1 splicing. Reduced SRSF1 favors the production of short isoforms of PTPMT1 upon ionizing radiation, which in turn promotes phosphorylation of AMPK, thereby inducing DNA double-strand break to sensitize cancer cells to irradiation.

SRSF1-dependent alternative splicing attenuates BIN1 expression in non-small cell lung cancer.

The SRSF1 and RBM4 constitute an antagonistic mechanism on regulating the splicing profiles of HIF-1alpha gene, which is relevant to the oncogenic signatures of lung cancer cells.