SFRP 1 gene is frequently downregulated by promoter hypermethylation and suppresses tumor growth activity of lung cancer cells, which suggests that SFRP 1 is a candidate tumor suppressor gene for lung cancer

epigenetic inactivation of SFRP1 is a common event contributing to lung carcinogenesis and maybe used as a potential biomarker for NSCLC in Chinese population.

SFRP1 gene methylation is closely associated with carcinogenesis and development of non-small cell lung cancer. 5-Aza-CdR may reverse the methylation of SFRP1, p16 and MGMT genes, and facilitate the re-expression of the anti-oncogenes.

Results provide evidence that SFRP1 is a clinically important determinant of taxanes resistance in human advanced lung adenocarcinoma (LAD) cells, suggesting that it might be a novel therapeutic target for the treatment of taxane-resistant LAD patients.

miR-1254 promotes lung cancer cell proliferation by targeting the expression of SFRP1.