SCD1 activity regulates Akt activation in human lung adenocarcinoma cells

data indicate that SCD activity may control lung cancer cell metabolism, proliferation and survival by modulating the EGFR-->Akt/ERK signaling platforms

The results suggest that SCD1 is a critical target in lung cancer tumor-initiating cells.

high expression of SCD1 is more frequently observed in late stage lung adenocarcinoma patients and presents poor prognosis

these data demonstrate for the first time the involvement of SCD1 in the regulation of the Hippo pathway in lung cancer, and point to fatty acids metabolism as a key regulator of lung cancer stem cells.

High SCD1 expression is associated with resistance to cisplatin in lung cancer.

SCD1 is a critical modulator of tumor cell proliferation that is activated by cathepsin B, secreted by lung fibroblasts at the metastatic niche.