Placenta growth factor directly regulates the motility of human lung cancer cells and that this regulation critically dependent on ROCK-1

Data indicate that Rho-associated protein kinase 1 (ROCK1) was inversely correlated with miR-186 expression in non-small cell lung cancer (NSCLC).

This study identifies FLI1 exonic circular RNAs as a new oncogenic driver that promotes tumor metastasis through the miR584-ROCK1 pathway. Importantly, serum exosomal FECR1 may serve as a promising biomarker to track disease progression of small cell lung cancer (SCLC)

Results demonstrated that ROCK1 is highly expressed in nonsmallcell lung cancer (NSCLC) cells and tissues, and is associated with poor survival. In addition, ROCK1 plays an important role in the occurrence and development of NSCLC through regulating cancer cell migration and invasion.

CircTIMELESS regulates the proliferation and invasion of lung squamous cell carcinoma cells via the miR-136-5p/ROCK1 axis.

miR-135a inhibits malignant proliferation and diffusion of non-small cell lung cancer cells by down-regulating ROCK1 protein.

ROCK1 knockdown inhibits non-small-cell lung cancer progression by activating the LATS2-JNK signaling pathway.

Baicalein suppresses vasculogenic mimicry through inhibiting RhoA/ROCK expression in lung cancer A549 cell line.

While the loss of either Rock1 or Rock2 had no negative impact on tumorigenesis in mouse models of non-small cell lung cancer and melanoma, loss of both blocked tumor formation, as no tumors arise in which both Rock1 and Rock2 have been genetically deleted.