Loss of retinoic acid receptor beta gene expression is linked to aberrant histone H3 acetylation in lung cancer cell lines.

RARbeta expression may be an indicator of increased risk of lung cancer in heavy smokers.

Review loss or abnormality of RAR-b in lung cancer cell lines. It may have tumor suppression function.

In H358 lung cancer cells transiently transfected with RARbeta1', RA treatment restored target gene expression compared with that in vector-transfected cells and suppressed cell growth compared with that in untreated cells.

hypermethylation in tumors from non-small cell lung cancer patients is associated with gender and histologic type

RAR-beta2 mRNAs increase signs the normal differentiation of the human bronchial epithelium while a decrease is observed in most lung cancer cell lines

Combined effects of cigarette smoke and hypermethylations of retinoic acid receptor beta are associated with non small cell lung cancer.

The p16, DAPK and RAR beta genes methylation are strongly associated with clinical data of non-small cell lung cancer, and methylation of p16 and DAPK genes are associated with tobacco smoking.

Circulating DNA-based testing verifies RARbeta2 methylation level is significantly increased in plasma from patients with non-small cell lung cancer compared with healthy individuals.

Significant correlation was found between alterations of methylation status of miR-9-1, miR-9-3, miR-34b/c, miR-193a and the expression level of RAR-beta2 target gene in the primary lung tumors.

The highest loss of heterozygosity and/or microsatellite imbalance is revealed in RARB locus in non-small cell lung cancer.

The total frequency of FHIT, RASSF1A and RARbeta gene methylation was significantly higher in lung cancer.

RARbeta2 circulating DNA in lung cancer patients is at greater methylation rate than in healthy donors.

Methylation of the RAR-beta gene with cigarette smoking is associated with non-small cell lung cancer.

shows that RAR-beta methylation detected in lung tissue may be used as a predictive marker for non-small cell lung cancer diagnosis and that APC methylation in tumor sample may be a useful marker

Lack of RARbeta nuclear expression is associated with Non-small cell lung cancer development and associated with a worse prognosis.

Results indicate that RARbeta hypermethylation correlates well with an increased risk in non-small cell lung cancer (NSCLC) patients. RARbeta gene inactivation caused by RARbeta methylation contributes the NSCLC tumorigenesis and may serve as a potential risk factor, diagnostic marker and drug target of NSCLC. [review]

RAR-beta expression state is one of the independent factors for the prognosis of lung squamous cell carcinoma patients

Hypermethylation of RARB gene is associated with high grade lung cancer.

Aberrant methylation of RAR-beta is an early and common alteration in murine lung tumors induced by several environmentally relevant exposures.