lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	5915
Symbol	RARB
Synonymous	HAP\|MCOPS12\|NR1B2\|RRB2
Full name	retinoic acid receptor, beta
Gene description	HBV-activated protein\|RAR-beta\|RAR-epsilon\|hepatitis B virus activated protein\|nuclear receptor subfamily 1 group B member 2\|retinoic acid receptor beta\|retinoic acid receptor, beta polypeptide
Cytoband	3p24.2
Gene type	protein-coding
Synonymous	MIM:180220; HGNC:HGNC:9865; Ensembl:ENSG00000077092; HPRD:07183; Vega:OTTHUMG00000130480

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.363G>C; p.K121N; 3:25501238-25501238	urinary_tract; bladder	carcinoma	Substitution - Missense
c.209C>A; p.S70Y; 3:25461244-25461244	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1200A>G; p.P400P; 3:25596469-25596469	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.697G>A; p.V233M; 3:25580633-25580633	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.434G>A; p.G145E; 3:25501309-25501309	breast	carcinoma	Substitution - Missense
c.355C>T; p.R119*; 3:25501230-25501230	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Nonsense
c.247G>A; p.V83I; 3:25461282-25461282	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.247G>A; p.V83I; 3:25461282-25461282	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.166A>G; p.T56A; 3:25461201-25461201	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.887G>A; p.G296D; 3:25593603-25593603	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1193C>T; p.S398L; 3:25596462-25596462	ovary	other; neoplasm	Substitution - Missense
c.1180G>A; p.E394K; 3:25596449-25596449	skin	malignant_melanoma	Substitution - Missense
c.184G>C; p.E62Q; 3:25461219-25461219	breast	carcinoma	Substitution - Missense
c.710A>T; p.K237I; 3:25580646-25580646	skin	malignant_melanoma	Substitution - Missense
c.1043T>A; p.L348*; 3:25594571-25594571	skin	malignant_melanoma	Substitution - Nonsense
c.504A>G; p.T168T; 3:25569813-25569813	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.648C>G; p.G216G; 3:25580584-25580584	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1151-11_1168del29; p.?; 3:25596409-25596437	breast	carcinoma	Unknown
c.1006G>C; p.E336Q; 3:25594534-25594534	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.860G>A; p.R287Q; 3:25593576-25593576	breast	carcinoma	Substitution - Missense
c.16G>A; p.D6N; 3:25428747-25428747	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.109T>G; p.F37V; 3:25428840-25428840	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.629G>C; p.R210P; 3:25580565-25580565	ovary	other; neoplasm	Substitution - Missense
c.1158G>A; p.E386E; 3:25596427-25596427	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.186G>T; p.E62D; 3:25461221-25461221	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.404A>C; p.Y135S; 3:25501279-25501279	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.991G>A; p.D331N; 3:25593707-25593707	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.966C>G; p.L322L; 3:25593682-25593682	skin	malignant_melanoma	Substitution - coding silent
c.539T>A; p.L180H; 3:25569848-25569848	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.394C>T; p.R132*; 3:25501269-25501269	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1078C>T; p.R360*; 3:25594606-25594606	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.992-1G>A; p.?; 3:25594519-25594519	large_intestine; colon	carcinoma; adenocarcinoma	Unknown
c.1078C>T; p.R360*; 3:25594606-25594606	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.206C>A; p.P69Q; 3:25461241-25461241	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.62C>T; p.A21V; 3:25428793-25428793	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.947A>G; p.D316G; 3:25593663-25593663	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.129C>T; p.T43T; 3:25428860-25428860	breast	carcinoma	Substitution - coding silent
c.505G>T; p.E169*; 3:25569814-25569814	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Nonsense
c.1037_1056del20; p.P347fs*26; 3:25594565-25594584	breast	carcinoma; ductal_carcinoma	Deletion - Frameshift
c.1150+1_1150+4delGTAT; p.?; 3:25594679-25594682	liver	carcinoma	Unknown
c.205C>T; p.P69S; 3:25461240-25461240	breast	carcinoma	Substitution - Missense
c.1204C>G; p.L402V; 3:25596473-25596473	urinary_tract; bladder	carcinoma	Substitution - Missense
c.488C>T; p.S163L; 3:25569797-25569797	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.297G>A; p.E99E; 3:25461332-25461332	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.400C>G; p.Q134E; 3:25501275-25501275	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.871C>T; p.H291Y; 3:25593587-25593587	large_intestine; colon	carcinoma	Substitution - Missense
c.871C>T; p.H291Y; 3:25593587-25593587	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1250C>T; p.T417I; 3:25596519-25596519	pleura	pulmonary_blastoma	Substitution - Missense
c.278A>G; p.Y93C; 3:25461313-25461313	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.113G>A; p.S38N; 3:25428844-25428844	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.811A>G; p.T271A; 3:25593527-25593527	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.546G>A; p.E182E; 3:25569855-25569855	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.366C>T; p.N122N; 3:25501241-25501241	lung	carcinoma; small_cell_carcinoma	Substitution - coding silent
c.612T>C; p.N204N; 3:25580548-25580548	prostate	adenoma	Substitution - coding silent
c.324T>A; p.S108R; 3:25501199-25501199	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.663C>T; p.F221F; 3:25580599-25580599	breast	carcinoma	Substitution - coding silent
c.248T>C; p.V83A; 3:25461283-25461283	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.219T>C; p.P73P; 3:25461254-25461254	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.535G>A; p.D179N; 3:25569844-25569844	skin	malignant_melanoma	Substitution - Missense
c.757C>T; p.L253L; 3:25580693-25580693	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.440_441CC>TT; p.S147F; 3:25501315-25501316	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1139T>C; p.I380T; 3:25594667-25594667	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.573T>G; p.T191T; 3:25569882-25569882	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.292T>A; p.C98S; 3:25461327-25461327	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.554G>A; p.R185Q; 3:25569863-25569863	skin	malignant_melanoma	Substitution - Missense
c.560C>T; p.A187V; 3:25569869-25569869	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.21T>C; p.V7V; 3:25428752-25428752	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.399C>A; p.C133*; 3:25501274-25501274	breast	carcinoma	Substitution - Nonsense
c.771C>T; p.A257A; 3:25580707-25580707	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.445G>T; p.E149*; 3:25501320-25501320	breast	carcinoma	Substitution - Nonsense
c.503C>T; p.T168I; 3:25569812-25569812	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.223C>G; p.P75A; 3:25461258-25461258	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.200_201insC; p.S70fs*30; 3:25461235-25461236	large_intestine; colon	carcinoma; adenocarcinoma	Insertion - Frameshift
c.859C>T; p.R287*; 3:25593575-25593575	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.727A>G; p.T243A; 3:25580663-25580663	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.742G>A; p.A248T; 3:25580678-25580678	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.356G>A; p.R119Q; 3:25501231-25501231	skin	malignant_melanoma	Substitution - Missense
c.310T>C; p.F104L; 3:25501185-25501185	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.410G>T; p.R137L; 3:25501285-25501285	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; chronic_myeloid_leukaemia	Substitution - Missense
c.229G>A; p.V77M; 3:25461264-25461264	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.805A>C; p.R269R; 3:25593521-25593521	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.243C>A; p.C81*; 3:25461278-25461278	ovary	carcinoma; serous_carcinoma	Substitution - Nonsense
c.226C>T; p.R76*; 3:25461261-25461261	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.647G>C; p.G216A; 3:25580583-25580583	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.673G>A; p.A225T; 3:25580609-25580609	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.673G>A; p.A225T; 3:25580609-25580609	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.505G>A; p.E169K; 3:25569814-25569814	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1132C>T; p.R378C; 3:25594660-25594660	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1278G>A; p.E426E; 3:25596547-25596547	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.645G>A; p.L215L; 3:25580581-25580581	breast	carcinoma	Substitution - coding silent
c.220delC; p.P75fs*39; 3:25461255-25461255	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.220delC; p.P75fs*39; 3:25461255-25461255	stomach	carcinoma; intestinal_adenocarcinoma	Deletion - Frameshift
c.492G>A; p.K164K; 3:25569801-25569801	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.220delC; p.P75fs*39; 3:25461255-25461255	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1094A>G; p.H365R; 3:25594622-25594622	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.395G>A; p.R132Q; 3:25501270-25501270	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.395G>A; p.R132Q; 3:25501270-25501270	pancreas	NS	Substitution - Missense
c.628C>T; p.R210*; 3:25580564-25580564	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.890C>A; p.P297H; 3:25593606-25593606	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.330G>T; p.Q110H; 3:25501205-25501205	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.595G>T; p.G199C; 3:25569904-25569904	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1160G>C; p.R387P; 3:25596429-25596429	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.538C>T; p.L180F; 3:25569847-25569847	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.387C>T; p.T129T; 3:25501262-25501262	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.630A>T; p.R210R; 3:25580566-25580566	breast	carcinoma	Substitution - coding silent

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation