These results establish an important role for paxillin in lung cancer.

Using lung adenocarcinoma samples and cell lines derived from lung adenocarcinomas, we demonstrated that the gene copy number for MET in lung adenocarcinoma tissue samples was increased over EGFR, HGF, and PXN and that it correlated with better prognosis

Expressed in most neuroendocrine tumors of lung. Significant correlation between PAX5 and paxillin was detected in SCLCs and large cell neuroendocrine carcinomas but not in carcinoid tumors.

In contrast to a previous report, this study showed that PXN mutation was absent in lung cancers and other common solid cancers, suggesting that PXN mutation may not play a principal role in solid cancer development.

The data suggests that mutant PXN variants play a prominent role in mitochondrial dynamics with direct implications on lung cancer progression.

Study provides evidence that phosphorylation of PXN is required for cisplatin resistance in lung cancer cells.

XIST positively regulated PXN levels by sponging miR-137 in vitro and in vivo. Collectively, our study provided the evidence for the cross-talk between XIST, miR-137, and PXN, shedding light on the therapy for non-small cell lung cancer .