Cancer metastasis database

Annotation category 5

Gene information

Gene ID 5829
Symbol

PXN

Synonymous

-

Full name

paxillin

Gene description

-

Cytoband

12q24.31

Gene type

protein-coding

Synonymous

MIM:602505; HGNC:HGNC:9718; Ensembl:ENSG00000089159; Vega:OTTHUMG00000169169

COSMIC somatic mutation

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.65C>T; p.P22L; 12:120224326-120224326

 prostatecarcinomaSubstitution - Missense

c.1510T>C; p.C504R; 12:120212478-120212478

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1544C>T; p.A515V; 12:120212444-120212444

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.439C>T; p.R147C; 12:120222917-120222917

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1089C>T; p.F363F; 12:120214912-120214912

 large_intestinecarcinoma; adenocarcinomaSubstitution - coding silent

c.641G>A; p.R214Q; 12:120222603-120222603

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.1587C>T; p.F529F; 12:120212401-120212401

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.217A>G; p.S73G; 12:120224174-120224174

 breastcarcinomaSubstitution - Missense

c.1506T>C; p.S502S; 12:120212482-120212482

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - coding silent

c.1591C>A; p.L531I; 12:120212397-120212397

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.440G>A; p.R147H; 12:120222916-120222916

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.152delC; p.P51fs*16; 12:120224239-120224239

 large_intestinecarcinoma; adenocarcinomaDeletion - Frameshift

c.1404C>T; p.C468C; 12:120213845-120213845

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - coding silent

c.477G>A; p.P159P; 12:120222879-120222879

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.1404C>T; p.C468C; 12:120213845-120213845

 large_intestinecarcinoma; adenocarcinomaSubstitution - coding silent

c.911T>C; p.L304P; 12:120215194-120215194

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1363T>G; p.S455A; 12:120213886-120213886

 central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - Missense

c.21G>T; p.L7L; 12:120224370-120224370

 ovarycarcinoma; serous_carcinomaSubstitution - coding silent

c.432A>C; p.E144D; 12:120222924-120222924

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.1254C>T; p.P418P; 12:120214140-120214140

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.605C>T; p.P202L; 12:120222639-120222639

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.1077C>T; p.S359S; 12:120214924-120214924

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.680C>T; p.S227F; 12:120222564-120222564

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.740G>A; p.R247H; 12:120221714-120221714

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.19C>T; p.L7L; 12:120224372-120224372

 boneEwings_sarcoma-peripheral_primitive_neuroectodermal_tumourSubstitution - coding silent

c.435C>T; p.L145L; 12:120222921-120222921

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.359T>C; p.F120S; 12:120222997-120222997

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.412C>A; p.L138M; 12:120222944-120222944

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.1527C>T; p.T509T; 12:120212461-120212461

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.152_153insC; p.P52fs*13; 12:120224238-120224239

 large_intestinecarcinoma; adenocarcinomaInsertion - Frameshift

c.1086C>G; p.F362L; 12:120214915-120214915

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.869delC; p.P290fs*22; 12:120215236-120215236

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaDeletion - Frameshift

c.1107C>A; p.P369P; 12:120214894-120214894

 urinary_tract; bladdercarcinomaSubstitution - coding silent

c.1075T>A; p.S359T; 12:120214926-120214926

 skinmalignant_melanomaSubstitution - Missense

c.1292G>A; p.R431H; 12:120213957-120213957

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.458A>T; p.N153I; 12:120222898-120222898

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.1145G>A; p.R382H; 12:120214856-120214856

 stomachcarcinoma; intestinal_adenocarcinomaSubstitution - Missense

c.402G>A; p.M134I; 12:120222954-120222954

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1483G>A; p.E495K; 12:120212505-120212505

 prostatecarcinoma; adenocarcinomaSubstitution - Missense

c.1275C>T; p.D425D; 12:120213974-120213974

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.443T>C; p.L148P; 12:120222913-120222913

 stomachcarcinoma; intestinal_adenocarcinomaSubstitution - Missense

c.1458G>T; p.Q486H; 12:120212530-120212530

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.723G>C; p.E241D; 12:120221731-120221731

 ovarycarcinoma; serous_carcinomaSubstitution - Missense

c.1317A>G; p.A439A; 12:120213932-120213932

 upper_aerodigestive_tract; pharynxcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.1314C>T; p.F438F; 12:120213935-120213935

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.1314C>T; p.F438F; 12:120213935-120213935

 breastcarcinomaSubstitution - coding silent

c.1261T>C; p.F421L; 12:120213988-120213988

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.720C>A; p.G240G; 12:120221734-120221734

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.65C>A; p.P22H; 12:120224326-120224326

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.1134C>T; p.L378L; 12:120214867-120214867

 skinmalignant_melanomaSubstitution - coding silent

c.360C>T; p.F120F; 12:120222996-120222996

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.1437C>T; p.S479S; 12:120212551-120212551

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.742G>A; p.V248I; 12:120221712-120221712

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.611G>A; p.R204Q; 12:120222633-120222633

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1635G>A; p.K545K; 12:120212353-120212353

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.1137C>G; p.F379L; 12:120214864-120214864

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.945G>A; p.G315G; 12:120215160-120215160

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.408G>A; p.T136T; 12:120222948-120222948

 thyroidother; neoplasmSubstitution - coding silent

c.1134C>G; p.L378L; 12:120214867-120214867

 lungcarcinoma; adenocarcinomaSubstitution - coding silent

c.720C>T; p.G240G; 12:120221734-120221734

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.1482C>T; p.H494H; 12:120212506-120212506

 lungcarcinoma; adenocarcinomaSubstitution - coding silent

c.832-10G>A; p.?; 12:120215283-120215283

 pancreascarcinomaUnknown

c.1339C>T; p.R447W; 12:120213910-120213910

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.1371C>T; p.L457L; 12:120213878-120213878

 breastcarcinoma; ER-PR-positive_carcinomaSubstitution - coding silent

c.876delG; p.P294fs*18; 12:120215229-120215229

 large_intestine; caecumcarcinoma; adenocarcinomaDeletion - Frameshift

c.1073G>A; p.G358E; 12:120214928-120214928

 skinmalignant_melanomaSubstitution - Missense

c.407C>T; p.T136M; 12:120222949-120222949

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.594G>A; p.T198T; 12:120222650-120222650

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.300T>C; p.P100P; 12:120223774-120223774

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.515C>T; p.P172L; 12:120222729-120222729

 livercarcinomaSubstitution - Missense

c.1505C>A; p.S502Y; 12:120212483-120212483

 ovarycarcinoma; serous_carcinomaSubstitution - Missense

c.1620G>A; p.K540K; 12:120212368-120212368

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - coding silent

c.1166C>T; p.P389L; 12:120214835-120214835

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense