In operable non-small lung cell cancers, there may be different relationship of this protein with paatient outcome.

The existence of polymorphisms in the ABCB1 gene and, specifically, the presence of the G2677T mutation can be crucial in conferring susceptibility to lung cancer.

high and low P-glycoprotein, glutathione S-transferase pi expression, excision repair cross-complementing 1 alterations, and tumor suppressor p53 mutation were candidates for future clinical trials of chemosensitivity tests in lung cancer patients.

MDR1 2677G-->T/A and 3435C-->T polymorphisms can be used to predict treatment response to vinorelbine-cisplatin chemotherapy in non-small cell lung cancer.

Determination of P-glycoprotein, MDR-related protein 1, breast cancer resistance protein, and lung-resistance protein expression in leukemic stem cells of acute myeloid leukemia.

The current study demonstrated that common polymorphisms in the 3' untranslated region of ABCB1 and ABCC1 may contribute to the etiology of lung cancer.

The expression of alpha-tubulin and MDR1 may play an important role in the development and progression of human non-small cell lung carcinoma.

MDR1 3435 CC genotype is an important prognostic factors associated with lower risk of progression of non-small-cell lung cancer patients

The expression of III beta-tubulin and MDR1 may play an important role in the development and progression of human non-small cell lung cancer.

Overexpression of MDR1 is associated with poor response to paclitaxel-based lung cancer chemoradiation.

expression of CapG, gelsolin, and P-gp was found to be associated with an increased risk of death from non-small cell lung cancer.

the ABCB1 1236TT-2677TT-3435TT genotype was associated with higher plasma concentration and the risk of developing higher toxicity in patients with non-small-cell lung cancertreated with erlotinib

study characterized genetic variability of the ABCB1 (also known as MDR1), ABCC2 (MRP2) and ABCG2 (BCRP) genes, which are key players in the metabolism of many chemotherapeutic agents including those used in the treatment of lung cancer

No significant association between severe toxicities and ABCB1 polymorphisms in non-small cell lung carcinoma patients treated with gefitinib.

Polymorphisms in MDR1 gene is associated with response to therapy in non small cell lung cancer.

analysis of MDR1 single nucleotide polymorphism C3435T in Turkish patients with non-small-cell lung cancer

Polymorphisms of genes in DNA repair pathway and MDR1 could contribute to chemotherapy response and survival of patients with non-small cell lung cancer.

Inherited variation in ABCB1 may affect survival specifically in advanced stage lung cancer patients who receive chemotherapy.

an etiologically relevant interaction between CYP2A13 and ABCB1 associated with lung cancer was analysed

Pelitinib (EKB-569) targets the up-regulation of ABCB1 and ABCG2 induced by hyperthermia to eradicate lung cancer

Data suggest that MDR1 over-expression is a possible mechanism of acquired resistance to 17-DMAG in lung cancer cells with ALK rearrangement.

Study showed mRNA expression of MDR1 was up-regulated in 80% of patients with lung cancer and MDR1 TT genotypes had higher risk for the development of the neoplasm.

Data show that inhibition of ATP binding cassette subfamily B member 1 (ABCB1) might be a novel therapeutic strategy for non-small cell lung cancer (NSCLC) patients with acquired resistance to proto-oncogene proteins c-met (MET) inhibitors.

Etoposide enhances antitumor efficacy of MDR1-driven oncolytic adenovirus through autoupregulation of the MDR1 promoter activity in lung neoplasm xenografts.

NSCLCs [ non-small cell lung cancer ] expressing P-gp [P-glycoprotein ]/LRP [ lung resistance-related protein] bear the EGFR [epidermal growth factor receptor] mutation in exon 19 or 21 easily.

results suggest that some Japanese non-small-cell lung cancer patients treated with crizotinib developed clinically significant toxicities that were related to altered pharmacokinetics parameters due to ABCB1 polymorphism and body weight factors

These results indicated that Adenovirus vector infection of non-small-cell lung cancer cells caused multi-drug resistance mediated by P-gp overexpression.

endothelin-A receptor-activated ABCB1 expression has a role in nintedanib resistance in FGFR1-driven small cell lung cancer

The study highlighted the connection between increased ABCB1 methylation level and upregulated expression of the gene in lung cancer. Moreover, the abnormally high expression of ABCB1 in A549 cells contributed to the development of the DDP resistance.

he modulatory effect of acacetin-doxorubicin combination on doxorubicin influx and efflux was mediated through downregulation of MDR1 treansporter in non-small-cell lung carcinoma (NSCLC) cells.

High ABCB1 expression is associated with vinorelbine resistance in lung cancer.

Asiatic Acid strongly inhibited P-GP expression by blocking MDR1 gene transcription and increased the intracellular accumulation of the P-GP substrate Rhodamine 123 in MDR1-overexpressing cisplatin (DDP)-resistant lung cancer cells, A549/DDP.

The rs1799971 and rs1323040 polymorphisms of the OPRM1 gene and rs2032582 and rs1128503 polymorphisms of the ABCB1 gene are related to the analgesic effect and consumed dose of sufentanil in Chinese Han patients undergoing radical operation of lung cancer.

The present study reveals that ABCB1 c.3435C>T polymorphism influences platinum toxicity in patients affected by non-small-cell and small-cell lung cancer

SNHG14 confers gefitinib resistance in non-small cell lung cancer by regulating miR-206-3p/ABCB1 pathway.

ABCB1 polymorphism G2677T/Aand C3435T correlated with high area under the concentration-time curve and poor taxane response in lung cancer and predict neurotoxicity of taxane-based chemotherapy.

Hesperetin reverses Pglycoproteinmediated cisplatin resistance in DDPresistant human lung cancer cells via modulation of the nuclear factorkappaB signaling pathway.

The impact of ABCB1 gene polymorphism and its expression on non-small-cell lung cancer development, progression and therapy - preliminary report.

LncRNA SNHG15 regulates EGFR-TKI acquired resistance in lung adenocarcinoma through sponging miR-451 to upregulate MDR-1.