WWOX hypermethylation analys9s could enrich a panel of DNA methylation markers in breast, lung and bladder cancer.

Reversing effect of exogenous WWOX gene expression on malignant phenotype of primary cultured lung carcinoma cells.

hypermethylation of WWOX gene promoter region and mutations in the gene is associated with non-small-cell lung cancer.

WWOX was identified as a Bmi1 target in small cell lung cancer cells

polymorphisms and haplotypes of WWOX gene are associated with the risk of lung cancer.

copy number variations in WWOX were significantly associated with an increased lung cancer risk in Chinese patients.

Loss of WWOX gene is associated with lung cancer.

overexpression of WWOX attenuated miR-134 induced H69 small cell lung cancer cell growth, and promoted cell apoptosis

WWOX expression was strongly inhibited in human lung cancers and lung cancer cell lines. Reintroducing WWOX into lung cancer cells inhibited their invasive phenotype through downregulating RUNX2 and its target genes including MMP-9 expression.