Links to all GeneRIF Items | 5155 |
PubMed (Gene Name) | Literature evidence |
|---|---|
| 17671690 (PDGFB) | endothelial and lung cancer cells seem to interact via various paracrine pathways, e.g. by the reciprocal induction of VEGF and PDGF-BB |
| 18758297 (PDGFB) | High tumor cell PDGF-B is associated with non-small cell lung cancer. |
| 30755260 (PDGFB) | Study demonstrates that breast cancer cells secrete CXCL17, which increases the accumulation of CD11b+Gr-1+ myeloid-derived suppressor cells (MDSCs) in the lungs. CXCL17 increases MDSCs PDGF-BB secretion which contributes to MDSC-mediated angiogenesis in the lung metastatic niche and colonization of breast cancer. Patients with high levels of CXCL17 have shorter distant metastasis-free and overall survival rates. |