human OGG1 Cys/Cys genotype may confer a 2-fold increased risk of lung cancer

the association of OGG1 Ser326Cys polymorphism was limited for the risk of lung adenocarcinoma

hOGG1 polymorphism is associated with lung cancer risk and is linked to exposure to tobacco smoke

Because there is an increased incidence of lung and small intestine cancer in Myh(-/-)/Ogg1(-/-) mice, these findings support a causal role for unrepaired oxidized DNA bases in cancer development.

Single nucleotide polymorphism may play a role in the pathogenesis of lung cancer in this population, particularly among heavily exposed women.

Meta-analyses found increased lung cancer risk among subjects carrying the OGG1 Cys/Cys genotype.

the OGG1 Ser326Cys polymorphism does not have a role in development of lung cancer

Individuals carrying the hOGG1 Cys/Cys genotype did not have significantly increased risk of lung cancer.

Our results suggest that the OGG1 Ser326Cys polymorphism is not a genetic risk factor for lung cancer, and that the heterozygous genotype is associated with a significantly reduced risk for lung cancer

The researchers found evidence of an association between the hOGG1 genotype and the risk of developing lung cancer based on cigarette smoking status.

Results indicate that hOGG1 rs1052133 contributes to the risk of adenocarcinoma of lung.

Reduced OGG1 is associated with lung cancer.

Results provide evidence that the C allele of hOGG1 codon 326 may have a joint effect with smoking on the development of lung cancer.

a SNP rs159153 in hOGG1 was significantly associated with higher TNM stage in patients with non-small cell lung cancer.

Cys326 genotype can significantly increase risk of lung cancer, especially in Asian ethnic population.

Polymorphisms in OGG1 gene is associated with lung squamous cell carcinoma.

The combined effects of polymorphisms within OGG1, APE1 and XRCC1 genes may contribute to the tumorigenesis of lung cancer

the hOGG1 Ser326Cys polymorphism might contribute to the risk of non-small cell lung cancer in the Asian population (Meta-Analysis)

The ser/Cys genotype of OGG1 did not have significantly increased risk for lung cancer (OR = 1.15, 95% CI = 0.98-1.36) when compared with the Ser/Ser genotype.

We demonstrated a novel, significant correlation between the hOGG1 Ser326Cys polymorphism and increased lung cancer susceptibility in Caucasians.

Ser/Cys polymorphism in OGG1 gene is associated with lung cancer.

These results suggest that the APE1 Asp/Asp genotype and the combination of the APE1 Asp/Asp and hOGG1-Cys variants are associated with increased risk of p53 mutation in non-small cell lung cancer.

OGG1 Ser326Cys show an increased lung cancer risk in Asians and non-smokers; APEX1 Asp148Glu polymorphism may be associated with decreased lung adenocarcinoma risk, and APEX1 Asp148Glu polymorphism show an increased lung cancer risk in Asians and smokers

A three-order interaction among the polymorphic sites of XPD-751, XRCC1-399, and OGG1-326 is associated with lung adenocarcinoma risk.

The OGG1 S326C polymorphic variant associated with lung cancer showed poorer base excision and lost sensitivity to the opposite-base methylation.

Review/Meta-analysis: hOGG1 Ser326Cys polymorphism contributed to the risk of lung cancer.

this meta-analysis provides solid evidence that hOGG1 Ser326Cys polymorphism may contribute to lung cancer risk, particularly for Asian populations, never smokers, and more-cigarette takers

The combined results suggested that the hOGG1 Ser326Cys polymorphism was not associated with lung cancer susceptibility in different genetic models.

The OGG1 Ser326Cys polymorphism may be a risk factor for cancers of lung, digestive system and head and neck.

Polymorphisms in OGG1 do not contribute to development of non-small cell lung cancer in Brazilian patients.

Provide strong evidence of an association between peripheral blood mononuclear cell hOGG1 methylation and the risk of non-small cell lung carcinoma in a Chinese population.

hOGG1 mRNA is downregulated in non-small cell lung cancer tissues. Methylated +322-327 CpG site in the hOGG1 5'-UTR is associated with reduced expression of hOGG1 by decreasing the recruitment of Sp1 to the 5'-UTR of hOGG1 in A549 cells.

Single allelic carriers for both OGG1 and MUTYH were risk factors towards lung cancer

Increased lung cancer risk was revealed in workers-carriers of homozygous minor genotype of genes OGG1] Ser326Cys (OR - 4.67, p = 0.007), APE1 Asp148Glu (OR = 1.82, p = 0.063) and XRCC1 Gln399Arg (OR = 2.86, p = 0.026).

The correlation of combined OGG1, CYP1A1 and GSTP1 gene variants and risk of lung cancer of male Iraqi waterpipe tobacco smokers.

Deficiencies in Myh and Ogg1 predispose 65.7% of mice to tumors, predominantly lung and ovarian tumors, and lymphomas.