study the null GSTM1 genotype is an independent risk factor for the development of lung cancer for Turkish population.

ATM variants were detected in about 14% of the lung cancer patients and did not differ significantly from the control subjects.

genetic polymorphism affects the risk of lung cancer among never smokers

We investigated the relationship between polymorphisms in ATM (A60G), ERCC1 (Asn118Asn), APE1 (Asn148Glu) and iASPP (A67T) and the risk of developing lung cancer

Results showed that no association between ATM IVS 22-77 T>C and cancer risk reached the level of statistical significance in the overall risk. In the stratified analyses, we observed an inverse relationship in lung and breast cancer.

ATDC upregulates MMP-9 to promote lung cancer cell invasion by activating ERK and JNK pathways.

ATDC promotes lung cancer cell proliferation by activating NF-kappaB pathway.

results provide evidence that the A allele of ATM rs652311 may be associated with lung cancer risk, and may enhance the effects of smoking habit on lung cancer development

cAMP signaling inhibits radiation-induced ATM activation by PKA-dependent activation of PP2A, and this signaling mechanism augments radiation-induced apoptosis by reducing ATM-dependent activation of NF-kappaB in lung cancer cells.

This case-control study showed that the ATM rs189037 SNP might be associated with the risk of lung adenocarcinoma in Chinese non-smoking females.

This study suggested that rs189037 (G>A) polymorphism is associated with lung cancer risk in Chinese Han population.

The combination of cisplatin and ATR inhibitor AZD6738 resolves ATM-deficient lung cancer xenografts.

ATM inhibition may facilitate the gefitinib-dependent repression of the phosphorylation of EGFR and/or its downstream factors, to exert anticancer effects against non-small-cell lung cancer cells with the sensitive EGFR mutation

Results show that mutant p53 ubiquitination status was regulated by ATM activation and downstream phosphorylation of mutant p53 (serine 15), both in resting and in genotoxin-treated lung cancer cells.

This meta-analysis suggests that AA genotype of the ATM-111 gene (G>A) may be a risk factor for breast cancer and lung cancer, especially among nonsmokers, within the Chinese population.

lung adenocarcinoma may be deficient in ATM protein; ATM could be a predictive biomarker for synergy of an ATR kinase inhibitor with standard-of-care cisplatin

ATM could be activated by lung cancer-associated TNF-alpha, up-regulate MMP-13 expression and thereby augment tumor metastasis

somatic mutations in the ataxia-telangiectasia mutated gene may have an effect of the phenotype of non-small cell lung cancer

Data suggest that ataxia telangiectasia mutated protein (ATM) mutational status in lung cancer is a mechanistic biomarker for MEK inhibitor response.

our results demonstrated that miR-30a may modulate the radiosensitivity of non-small cell lung cancer (NSCLC) through reducing the function of ATF1 in phosphorylation of ATM and have potential therapeutic value.

these results indicate that ATM loss seems to be an early event in non-small cell lung cancer carcinogenesis and is an independent prognostic factor associated with worse survival in stage II/III patients.

The polymorphisms rs664143 and rs664677 of ATM are associated with lung cancer occurrence

Variations in the ATM gene and its encoding product, the ATM protein, are found to affect the pathogenesis, development, response to treatment and prognosis of lung cancer

The ATM rs189037, rs664677 and rs664143 gene polymorphisms are risk factors for lung cancer, while the ATM rs189037 variant was significantly associated with radiation-induced pneumonitis risk. [meta-analysis]

these results indicate that miR-18a-5p increases the radiosensitivity in lung cancer cells and CD133(+) stem-like cells via downregulating ATM and HIF-1alpha expressions. Plasma miR-18a-5p would be an available indicator of radiosensitivity in lung cancer patients.

No significant association of ATM rs11212592 with lung cancer was found in five genetic models in Chinese population. Haplotypes consisting of PPP1R13L rs1970764 and ATM rs11212592 may be associated with lung cancer.

Results of the meta-analysis suggest that rs189037 is associated with the occurrence of lung cancer, breast cancer, and oral cancer.

ATM modulates vimentin expression to facilitate IL-6-induced epithelial-mesenchymal transition and metastasis in lung cancer, indicating that ATM and vimentin might be potential therapeutic targets for inflammation-associated lung cancer metastasis.

ATM gene polymorphisms are associated with poor prognosis of non-small cell lung cancer receiving radiation therapy.

Protein-altering germline mutations implicate novel genes related to lung cancer development.

Inherited Rare, Deleterious Variants in ATM Increase lung Adenocarcinoma Risk.