| mdm2(h) + ATM(h) <==> mdm2(h):ATM(h) (binding)
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ATM(h) + p53(h) <==> ATM(h):p53(h) (binding)
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ATM(h) --Caspase-3(h)--> protein remnants (processing)
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ATM(h) --Caspase-7(h)--> protein remnants (processing)
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ATM(h) + ATP --> ATM(h){pS1981} + ADP (phosphorylation; automodification)
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ATM(h) + MOF(h) <==> ATM(h):MOF(h) (binding)
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ATM(h) + Wip1(h) <==> ATM(h):Wip1(h) (binding)
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Wip1(m.s.) + ATM(h) <==> Wip1(m.s.):ATM(h) (binding)
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ATM(h) --> protein remnants (cleavage)
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ATM(h) --Caspase-3(m.s.)--> ATM-p210(h) + ATM-p150(h) + protein remnants (cleavage)
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ATM(h) --> ATM-p210(h) + protein remnants (cleavage)
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ATM(h) + BAAT1(h) <==> ATM(h):BAAT1(h) (binding)
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ATM(h) --> ATM(h) (translocation)
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ATM(h) + PP2A(h) <==> ATM(h):PP2A(h) (binding)
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ATM(h) + ATP --> ATM(h){pS1981} + ADP (phosphorylation)
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ATM(h) --> brca1(h):Mre11(h) (increase of binding)
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RFC4(h) + RFC2(h) + MLH1(h) + MSH2(h) + RECC1(h) + BLM(h) + ATM(h) + brca1(h) + GTBP(h) <==> RFC4(h):RFC2(h):MLH1(h):MSH2(h):RECC1(h):BLM(h):ATM(h):brca1(h):GTBP(h) (binding)
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ATM(h) + brca1(h) <==> ATM(h):brca1(h) (binding)
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ATM(h) + RECC1(h) <==> ATM(h):RECC1(h) (binding)
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GTBP(h) + ATM(h) <==> GTBP(h):ATM(h) (binding)
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BLM(h) + ATM(h) <==> BLM(h):ATM(h) (binding)
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ATM(h) + Rad50(h) <==> ATM(h):Rad50(h) (binding)
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ATM(h) + Mre11(h) <==> ATM(h):Mre11(h) (binding)
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ATM(h) + MSH2(h) <==> ATM(h):MSH2(h) (binding)
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ATM(h) + MLH1(h) <==> ATM(h):MLH1(h) (binding)
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BLM(h) + Rad50(h) + MSH2(h) + ATM(h) + brca1(h) + RECC1(h) <==> BLM(h):Rad50(h):MSH2(h):ATM(h):brca1(h):RECC1(h) (binding)
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ATM(h) --> brca1(h){p}n (increase of phosphorylation)
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ATM(h) + ATP --> ATM(h){p} + ADP (phosphorylation)
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ATM(h) + ATP --> ATM(h){p} + ADP (automodification)
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ATM(h) + obfc2b(h) <==> ATM(h):obfc2b(h) + ATM(h):obfc2b(h) (binding)
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ATM(h) + Apak(h) <==> ATM(h):Apak(h) (binding)
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HDAC1(h) + RNF96(h) + Apak(h) + ATM(h) + p53(h) <==> HDAC1(h):RNF96(h):Apak(h):ATM(h):p53(h) (binding)
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p53(h) + Apak(h) + ATM(h) <==> p53(h):Apak(h):ATM(h) (binding)
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H2O2 --> ATM(h) (activation)
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ATM(h) --> ATM(h) (expression).
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ATM(h) --> ATM(h) (translocation)
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ATM(h){pS1981} --PP2A(h)--> ATM(h) + p (dephosphorylation)
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p53(h) + ATP --ATM(h)--> p53(h){pS15} + ADP (phosphorylation)
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p53(h) + ATP --ATM(h)--> p53(h){pS20} + ADP (phosphorylation)
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Chk2(h) + ATP --ATM(h)--> Chk2(h){pT68} + ADP (phosphorylation)
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53BP1(h) + ATP --ATM(h)--> 53BP1(h){p} + ADP (phosphorylation)
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LKB1(m) + ATP --ATM(h)--> LKB1(m){pT366} + ADP (phosphorylation)
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Chk1(v.s.) + ATP --ATM(h)--> Chk1(v.s.){pS345} + ADP (phosphorylation)
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mdm2(h) + ATP --ATM(h)--> mdm2(h){p} + ADP (phosphorylation)
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mdm2(h) + ATP --ATM(h)--> mdm2(h){pS395} + ADP (phosphorylation)
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p53(m.s.) + ATP --ATM(h)--> p53(m.s.){pS15} + ADP (phosphorylation)
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Bid(m) + 2 ATP --ATM(h)--> Bid(m){pS61}{pS78} + 2 ADP (phosphorylation)
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Bid(h) + ATP --ATM(h)--> Bid(h){pS78} + ADP (phosphorylation)
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Artemis-isoform1(h) + 3 ATP --ATM(h)--> Artemis-isoform1(h){pS503}{pS516}{pS645} + 3 ADP (phosphorylation)
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Artemis(h) + ATP --ATM(h)--> Artemis(h){pS645} + ADP (phosphorylation)
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Mdm4(h) + ATP --ATM(h)--> Mdm4(h){pS403} + ADP (phosphorylation)
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CREB(h) + 3 ATP --ATM(h)--> CREB(h){pT100}{pS111}{pS121} + 3 ADP (phosphorylation)
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CREB1(h) + ATP --ATM(h)--> CREB1(h){pS121} + ADP (phosphorylation)
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p53(m.s.) + ATP --ATM(h)--> p53(m.s.){p} + ADP (phosphorylation)
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BAF170(h) + ATP --ATM(h)--> BAF170(h){pS969} + ADP (phosphorylation)
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MOF(h) + ATM(h) <==> MOF(h):ATM(h) (binding)
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ATM(h) + MOF-isoform1(h) <==> ATM(h):MOF-isoform1(h) (binding)
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2 ATM(h) <==> (ATM(h))2 (oligomerization)
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ATM(h) + ATP --> ATM(h){pS1981} + ADP (phosphorylation; automodification)
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ATM(h) + 2 ATP --ATM(m.s.)--> ATM(h){pS440}{pS2761} + 2 ADP (phosphorylation)
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ATM(h) + 2 ATP --ATR(m.s.)--> ATM(h){pS440}{pS2761} + 2 ADP (phosphorylation)
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ATM(h) + ATP --DNA-PK(m.s.)--> ATM(h){pS440} + ADP (phosphorylation)
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ATM(h) --/ bbc3(h) (transrepression)
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ATM(h) --/ P53AIP1(h) (transrepression)
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ATM(h) --/ PMAIP1(h) (transrepression)
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ATM(h) --/ CDKN1A(h) (transrepression)
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ATM(h) --/ SFN(h) (transrepression)
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ATM(h) --> ATM(h) (expression).
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ATM(h){pS1981} --Wip1(h)--> ATM(h) + p (dephosphorylation)
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ATM(h){pS1981} --Wip1(m.s.)--> ATM(h) + p (dephosphorylation)
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ATM(h){pS1981} --PP2A(m.s.)--> ATM(h) + p (dephosphorylation)
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p53(m.s.) + ATP --ATM(h)--> p53(m.s.){pS15} + ADP (phosphorylation)
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Bid(m) + 2 ATP --ATM(h)--> Bid(m){pS61}{pS78} + 2 ADP (phosphorylation)
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