Stromal macrophage expressing CD204 is associated with tumor aggressiveness in lung adenocarcinoma.

Data suggest that pulmonary metastasis is corrected with levels of Geminin, cleaved caspase-3, CD44, E-cadherin, epidermal growth factor receptor, and CD204 in cancer cells within permeated lymphatic vessels.

We identified in a Chinese population a functional polymorphism in SR-A linked to lung cancer risk. In vivo and in vitro studies demonstrated that SR-A may negatively modulate lung cancer growth and angiogenesis by regulating MMP9 production.

High CD204 expression is associated with metastasis and recurrence in non-small-cell lung cancer.

SR-A1 suppresses lung cancer metastasis by downregulating SAA1 production in tumor-associated macrophages (TAM).

The expression of CD204 in tumor-associated macrophages is associated with the aggressiveness of lung adenocarcinoma.