O(6)-Methylguanine-DNA methyltransferase promoter hypermethylation shifts the p53 mutational spectrum in non-small cell lung cancer.

MGMT codon 178 (and possibly 143) polymorphisms do not appear to markedly affect lung cancer risk in this Caucasian population.

Findings suggest that MGMT inactivation is an event that occurs in the late carcinogenic process in pulmonary squamous cell carcinoma and pulmonary adenocarcinoma.

O6-alkylguanine-DNA alkyltransferase gene polymorphisms is associated with lung cancer

tobacco smoking may be associated with an increased incidence of aberrant promoter methylation of the p16 and MGMT genes in non-small cell lung cancer

findings suggest that genetic variants in MGMT may modulate the risk of smoking-related lung cancer

MGMT polymorphisms and their association with risk for lung, breast, colorectal and endometrial cancer with a consideration of gene-environment interactions

Single nucleotide polymorphisms in the first intron and codon of the O6-alkylguanine-DNA alkyltransferase gene protect against lung cancer

MGMT promoter methylation modulated by p53 status could partially promote p53 mutation occurrence in advanced lung tumors

O6-methylguanine-DNA methyltransferase promoter methylation with p53 mutation occurrence is associated with non-small cell lung cancer.

enhanced expression in brain metastases of lung cancer; correlates with better survival

The loss of expression of MGMT may lead to activation of the wild-type p53 in lung carcinomatosis, and may predict prognosis in patients with non-small cell lung cancer.

The present study provides strong evidence for a higher frequency of promoter methylation of the MGMT gene in nonsmall cell lung cancer (NSCLC), indicating that it is a common event during the carcinogenesis of NSCLC.

the A allele of a O-6-methylguanine-DNA methyltransferase promoter-enhancer single nucleotide polymorphism is a key determinant for methylation of the protein in lung carcinogenesis

O6-methylguanine-DNA-methyl transferase promoter methylation is associated with recurrence in non-small-cell lung cancer. patients with brain metastasis

Three SNPs in the MGMT gene (adjusted analysis, rs3858300; unadjusted analysis, rs10741191 and rs3852507) from DNA repair pathway were associated with overall quality of life in patients with lung cancer.

meta-analysis identified a strong association between methylation of MGMT gene and non-small cell lung cancer

meta-analysis suggests that the MGMT Leu84Phe polymorphisms are associated with lung cancer risk among Caucasians not in Asians

Methylation rate in MGMT gene promoter of cancer tissue in non-small cell lung cancer

Data revealed that MGMT gene methylation was higher in non-small-cell lung carcinoma (NSCLC) tissue samples than normal. Also advanced stage NSCLC patients showed higher methylation than early stage patients without impacting patients survival. These results provided clear evidence about the association of MGMT hypermethylation with increased risk of NSCLC. [review]

Results find that MGMT expression is directly regulated by TRPS1 which binds to its promotor region. Further findings consider that upregulation of Trps1 induces MGMT transcription contributing to the formation of multidrug resistance phenotype in lung cancer cells.

MGMT rs12917 and higher levels of methylation in the MGMT promoter are associated with the risk of lung cancer

Data provide a strong evidence for association involving MGMT methylation on non-small cell lung cancer risk. [review]

[The role of lung cancer related gene methylation in the early diagnosis of lung cancer].