Cancer metastasis database

Annotation category 5

Gene information

Gene ID 4255
Symbol

MGMT

Synonymous

-

Full name

O-6-methylguanine-DNA methyltransferase

Gene description

6-O-methylguanine-DNA methyltransferase|O-6-methylguanine-DNA-alkyltransferase|O6-methylguanine-DNA methyltransferase|methylated-DNA--protein-cysteine methyltransferase|methylguanine-DNA methyltransferase

Cytoband

10q26

Gene type

protein-coding

Synonymous

MIM:156569; HGNC:HGNC:7059; HPRD:01135

COSMIC somatic mutation

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.72delT; p.C24fs*8; 10:129536324-129536324

 prostatecarcinomaDeletion - Frameshift

c.452G>A; p.S151N; 10:129766825-129766825

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.250C>T; p.L84F; 10:129708019-129708019

 haematopoietic_and_lymphoid_tissuehaematopoietic_neoplasm; acute_myeloid_leukaemiaSubstitution - Missense

c.210C>T; p.F70F; 10:129707979-129707979

 skinmalignant_melanomaSubstitution - coding silent

c.489C>T; p.A163A; 10:129766862-129766862

 boneEwings_sarcoma-peripheral_primitive_neuroectodermal_tumourSubstitution - coding silent

c.254A>G; p.H85R; 10:129708023-129708023

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.413C>T; p.P138L; 10:129759340-129759340

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.590C>A; p.A197D; 10:129766963-129766963

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.603C>T; p.S201S; 10:129766976-129766976

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.71G>A; p.C24Y; 10:129536323-129536323

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.260C>T; p.P87L; 10:129708029-129708029

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.559C>G; p.L187V; 10:129766932-129766932

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.198G>A; p.L66L; 10:129707967-129707967

 breastcarcinomaSubstitution - coding silent

c.198G>A; p.L66L; 10:129707967-129707967

 thyroidcarcinomaSubstitution - coding silent

c.228C>T; p.I76I; 10:129707997-129707997

 skinmalignant_melanomaSubstitution - coding silent

c.228C>T; p.I76I; 10:129707997-129707997

 ovarycarcinoma; serous_carcinomaSubstitution - coding silent

c.228C>T; p.I76I; 10:129707997-129707997

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.390G>T; p.V130V; 10:129759317-129759317

 oesophaguscarcinoma; adenocarcinomaSubstitution - coding silent

c.43C>T; p.P15S; 10:129536295-129536295

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.250C>A; p.L84I; 10:129708019-129708019

 haematopoietic_and_lymphoid_tissuehaematopoietic_neoplasm; acute_myeloid_leukaemiaSubstitution - Missense

c.287G>A; p.R96K; 10:129759214-129759214

 breastcarcinomaSubstitution - Missense

c.466G>T; p.G156C; 10:129766839-129766839

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.435C>A; p.C145*; 10:129766808-129766808

 breastcarcinomaSubstitution - Nonsense

c.430C>T; p.P144S; 10:129766803-129766803

 skinmalignant_melanomaSubstitution - Missense

c.79G>T; p.G27C; 10:129536331-129536331

 biliary_tract; bile_ductcarcinoma; adenocarcinomaSubstitution - Missense

c.380C>T; p.A127V; 10:129759307-129759307

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.114G>T; p.T38T; 10:129536366-129536366

 thyroidother; neoplasmSubstitution - coding silent

c.163G>T; p.G55C; 10:129707932-129707932

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.294G>T; p.V98V; 10:129759221-129759221

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.163G>T; p.G55C; 10:129707932-129707932

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.456C>T; p.S152S; 10:129766829-129766829

 breastcarcinomaSubstitution - coding silent

c.226A>G; p.I76V; 10:129707995-129707995

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.167C>T; p.P56L; 10:129707936-129707936

 skinmalignant_melanomaSubstitution - Missense

c.459A>T; p.G153G; 10:129766832-129766832

 large_intestinecarcinoma; adenocarcinomaSubstitution - coding silent

c.382C>T; p.R128*; 10:129759309-129759309

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Nonsense

c.118G>A; p.A40T; 10:129536370-129536370

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.246G>T; p.P82P; 10:129708015-129708015

 lungcarcinoma; adenocarcinomaSubstitution - coding silent

c.598G>T; p.G200C; 10:129766971-129766971

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.479G>A; p.G160E; 10:129766852-129766852

 skinmalignant_melanomaSubstitution - Missense

c.314T>C; p.V105A; 10:129759241-129759241

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.23A>G; p.K8R; 10:129536275-129536275

 skinmalignant_melanomaSubstitution - Missense

c.285C>A; p.T95T; 10:129759212-129759212

 lungcarcinoma; adenocarcinomaSubstitution - coding silent

c.132G>A; p.V44V; 10:129707901-129707901

 skinmalignant_melanomaSubstitution - coding silent

c.133G>T; p.E45*; 10:129707902-129707902

 lungcarcinoma; adenocarcinomaSubstitution - Nonsense

c.328G>T; p.E110*; 10:129759255-129759255

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Nonsense

c.26G>A; p.R9H; 10:129536278-129536278

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.26G>A; p.R9H; 10:129536278-129536278

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.587G>T; p.G196V; 10:129766960-129766960

 prostatecarcinoma; adenocarcinomaSubstitution - Missense

c.436C>G; p.H146D; 10:129766809-129766809

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.545G>A; p.G182E; 10:129766918-129766918

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.25C>T; p.R9C; 10:129536277-129536277

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.617G>A; p.R206Q; 10:129766990-129766990

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.159C>T; p.L53L; 10:129707928-129707928

 haematopoietic_and_lymphoid_tissuehaematopoietic_neoplasm; acute_myeloid_leukaemiaSubstitution - coding silent

c.371C>T; p.P124L; 10:129759298-129759298

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; hairy_cell_leukaemiaSubstitution - Missense

c.597G>A; p.S199S; 10:129766970-129766970

 oesophaguscarcinoma; adenocarcinomaSubstitution - coding silent

c.415-2A>C; p.?; 10:129766786-129766786

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphomaUnknown

c.415-2A>C; p.?; 10:129766786-129766786

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphomaUnknown

c.87C>T; p.H29H; 10:129536339-129536339

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - coding silent

c.350T>C; p.L117S; 10:129759277-129759277

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.382C>A; p.R128R; 10:129759309-129759309

 thyroidother; neoplasmSubstitution - coding silent

c.533A>G; p.K178R; 10:129766906-129766906

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.266T>C; p.F89S; 10:129708035-129708035

 skin; trunkmalignant_melanoma; nodularSubstitution - Missense

c.8A>G; p.K3R; 10:129536260-129536260

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.152C>T; p.A51V; 10:129707921-129707921

 central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - Missense

c.152C>T; p.A51V; 10:129707921-129707921

 central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - Missense

c.318G>A; p.V106V; 10:129759245-129759245

 breastcarcinoma; HER-positive_carcinomaSubstitution - coding silent

c.426C>T; p.L142L; 10:129766799-129766799

 skinmalignant_melanomaSubstitution - coding silent