Increased expression of PGE2 in the lung tumor microenvironment may initiate a mitogenic signaling cascade composed of EP4, betaArrestin1, and c-Src which mediates cancer cell migration.

betaArr1 and Mcl-1 are involved in the self-renewal and expansion of non-small cell lung carcinoma -cancer stem cells and are potential targets for anti-cancer therapy.

High ARBB1 expression is associated with metastasis in non-small cell lung cancers.

Stimulation of multiple non-small cell lung cancer cell lines with nicotine led to enhanced recruitment of beta-arrestin-1 and E2F1 on vimentin

We conclude that beta-arrestin1 had a high expression in lung adenocarcinoma and beta-arrestin1 may be a promising biomarker to identify individuals with poor prognosis for patients with lung adenocarcinoma.

In non-small cell lung cancer patients, the loss expression of beta-arrestin1 was frequently observed, and beta-arrestin1 expression was significantly correlated with the smoking index and E-cadherin expression, which all indicated beta-arrestin1's significant clinicopathologic role

Low expression of ARRB1 is associated with lung cancer.

Beta-arrestin-1 expression was significantly higher lung in adenocarcinoma (ADC) versus squamous cell carcinoma (SCC) of the lung samples, and identified as a diagnostic marker to differentiate ADC from SCC and a potential plasma biomarker for non-invasive diagnosis of lung cancer.

miR3795p inhibits cell proliferation and promotes cell apoptosis in nonsmall cell lung cancer by targeting betaarrestin1.