Non-small-cell lung cancers examined were found to overexpress LGALS3 gene at levels three times higher than those of normal epithelial cells.

nuclear galectin-3 and TTF-1 have roles in progression of non-small cell lung carcinoma

Galectin has a role in cell migration in cultured lung and prostate cancer cells

High serum levels and high mRNA expression of Gal-3 and OPN in non-small cell lung cancer are closely related to the occurrence and metastasis of NSCLC.

We didn't reveal any important correlations between clinicopathological findings and galectin-3 and cyclin D1 expression and in non small cell lung cancer. We didn't observed also prognostic value of cyclin D1 or galectin-3 expression.

galectin-3 enhances lung cancer stemness through the EGFR/c-Myc/Sox2 axis.

Study confirmed that galectin-3 as a ligand of TLR4 induced TLR4 signaling activation in lung adenocarcinoma cells, thereby activating downstream p65 nucleus translocation, promoting NEAT1 expression, and finally affecting lung adenocarcinoma cell proliferation and migration.

Study report that galectin3 expression is upregulated in nonsmall cell lung cancer cells under hypoxia and that it contributes to tumor cell migration and invasion. Cell motility is upregulated by the function of activated RhoA, which is induced by high levels of cytoplasmic galectin3.

Disrupted galectin-3 may attenuate the lung carcinogenesis