Aberrantly spliced CK8 (AS-CK8) that lacks caspases cleavage site identified in lung cancer cell lines and primary tumors of NSCLC. Suggests that cancer cells expressing AS-CK8 may have resistance to apoptosis and may perturb keratin network formation.

Apoptosis causes extracellular release of full-length CK8 in non-small cell lung cancer(NSCLC) cells; CK8 circulates predominantly in full length in NSCLC patients, illustrating fundamental differences in protein processing between type I and type II CKs.

There was a significant difference between AP, CK 7 and CK 8 expressions in primary lung adenocarcinomas (P=0.02; Chi-squared test).

the expression of Cytokeratins 7, 8, 18, and 19 may serve as differential diagnostic markers for pulmonary large cell neuroendocrine carcinoma and small cell lung carcinoma

KRT8 is aberrantly expressed in lung adenocarcinoma tissues. KRT8 expression is an independent prognostic indicator for poor survival in lung adenocarcinoma patients.

KRT8 and KRT19, associated with EMT, are hypomethylated and overexpressed in lung adenocarcinoma and link to unfavorable prognosis.