lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	3856
Symbol	KRT8
Synonymous	CARD2\|CK-8\|CK8\|CYK8\|K2C8\|K8\|KO
Full name	keratin 8, type II
Gene description	cytokeratin 8\|cytokeratin-8\|keratin, type II cytoskeletal 8\|type-II keratin Kb8
Cytoband	12q13
Gene type	protein-coding
Synonymous	MIM:148060; HGNC:HGNC:6446; Ensembl:ENSG00000170421; HPRD:01015; Vega:OTTHUMG00000169881

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.181G>T; p.G61*; 12:52904801-52904801	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.873C>T; p.S291S; 12:52899883-52899883	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1262-2A>G; p.?; 12:52897620-52897620	endometrium	carcinoma; endometrioid_carcinoma	Unknown
c.284T>A; p.I95N; 12:52904698-52904698	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.92C>A; p.S31Y; 12:52904890-52904890	kidney	other; neoplasm	Substitution - Missense
c.586A>G; p.I196V; 12:52901167-52901167	biliary_tract; gallbladder	carcinoma; adenocarcinoma	Substitution - Missense
c.1107G>T; p.R369R; 12:52898774-52898774	liver	carcinoma; hepatocellular_carcinoma	Substitution - coding silent
c.905G>A; p.R302H; 12:52899851-52899851	central_nervous_system; brain	glioma	Substitution - Missense
c.888C>T; p.H296H; 12:52899868-52899868	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.888C>T; p.H296H; 12:52899868-52899868	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.888C>T; p.H296H; 12:52899868-52899868	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.413_414insA; p.N138fs*11; 12:52901983-52901984	large_intestine; colon	carcinoma; adenocarcinoma	Insertion - Frameshift
c.594_594+1insAA; p.D199fs*8; 12:52901158-52901159	stomach	carcinoma; intestinal_adenocarcinoma	Unknown
c.888C>T; p.H296H; 12:52899868-52899868	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.1448A>T; p.K483M; 12:52897432-52897432	skin	malignant_melanoma	Substitution - Missense
c.802G>A; p.E268K; 12:52899954-52899954	skin	malignant_melanoma	Substitution - Missense
c.1073C>T; p.A358V; 12:52898808-52898808	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1079T>C; p.L360P; 12:52898802-52898802	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.878C>T; p.A293V; 12:52899878-52899878	skin	malignant_melanoma	Substitution - Missense
c.1075G>A; p.A359T; 12:52898806-52898806	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.338A>T; p.E113V; 12:52902059-52902059	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.399A>G; p.R133R; 12:52901998-52901998	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.1329T>C; p.F443F; 12:52897551-52897551	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1102G>A; p.A368T; 12:52898779-52898779	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1050C>T; p.N350N; 12:52898831-52898831	ovary	other; neoplasm	Substitution - coding silent
c.151G>C; p.G51R; 12:52904831-52904831	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.142G>C; p.G48R; 12:52904840-52904840	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.151G>C; p.G51R; 12:52904831-52904831	urinary_tract; bladder	carcinoma	Substitution - Missense
c.142G>C; p.G48R; 12:52904840-52904840	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1051G>A; p.A351T; 12:52898830-52898830	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.644A>T; p.E215V; 12:52900634-52900634	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1051G>A; p.A351T; 12:52898830-52898830	breast	carcinoma	Substitution - Missense
c.1159G>A; p.E387K; 12:52898722-52898722	skin	malignant_melanoma	Substitution - Missense
c.1115G>T; p.R372L; 12:52898766-52898766	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.285C>A; p.I95I; 12:52904697-52904697	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.509G>T; p.G170V; 12:52901888-52901888	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.723C>G; p.D241E; 12:52900033-52900033	ovary	other; neoplasm	Substitution - Missense
c.1360C>G; p.R454G; 12:52897520-52897520	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.87C>T; p.P29P; 12:52904895-52904895	bone; pelvis	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.1179G>T; p.K393N; 12:52898702-52898702	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.736C>T; p.L246L; 12:52900020-52900020	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.369G>C; p.W123C; 12:52902028-52902028	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.96C>T; p.R32R; 12:52904886-52904886	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.556C>T; p.R186C; 12:52901197-52901197	oesophagus	carcinoma	Substitution - Missense
c.534-1G>T; p.?; 12:52901220-52901220	stomach	carcinoma; adenocarcinoma	Unknown
c.574G>A; p.E192K; 12:52901179-52901179	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.574G>A; p.E192K; 12:52901179-52901179	skin; arm	malignant_melanoma	Substitution - Missense
c.1078C>A; p.L360M; 12:52898803-52898803	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.67C>T; p.R23C; 12:52904915-52904915	urinary_tract; bladder	carcinoma	Substitution - Missense
c.67C>T; p.R23C; 12:52904915-52904915	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.67C>T; p.R23C; 12:52904915-52904915	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.67C>T; p.R23C; 12:52904915-52904915	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.67C>T; p.R23C; 12:52904915-52904915	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.26C>T; p.S9F; 12:52904956-52904956	skin	malignant_melanoma	Substitution - Missense
c.1061C>A; p.S354Y; 12:52898820-52898820	prostate	adenoma	Substitution - Missense
c.463G>T; p.G155C; 12:52901934-52901934	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1407T>C; p.R469R; 12:52897473-52897473	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.420C>T; p.F140F; 12:52901977-52901977	skin	malignant_melanoma	Substitution - coding silent
c.420C>T; p.F140F; 12:52901977-52901977	skin	malignant_melanoma	Substitution - coding silent
c.1106G>A; p.R369Q; 12:52898775-52898775	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.681A>G; p.L227L; 12:52900597-52900597	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.681A>G; p.L227L; 12:52900597-52900597	thyroid	other; neoplasm	Substitution - coding silent
c.91T>G; p.S31A; 12:52904891-52904891	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.91T>G; p.S31A; 12:52904891-52904891	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.91T>G; p.S31A; 12:52904891-52904891	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.91T>G; p.S31A; 12:52904891-52904891	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.91T>G; p.S31A; 12:52904891-52904891	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.91T>G; p.S31A; 12:52904891-52904891	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.91T>G; p.S31A; 12:52904891-52904891	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.91T>G; p.S31A; 12:52904891-52904891	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.91T>G; p.S31A; 12:52904891-52904891	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.91T>G; p.S31A; 12:52904891-52904891	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.91T>G; p.S31A; 12:52904891-52904891	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.91T>G; p.S31A; 12:52904891-52904891	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.91T>G; p.S31A; 12:52904891-52904891	prostate	carcinoma	Substitution - Missense
c.300_302delCAA; p.N100delN; 12:52904680-52904682	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - In frame
c.300_302delCAA; p.N100delN; 12:52904680-52904682	stomach	adenocarcinoma	Deletion - In frame
c.627G>C; p.E209D; 12:52900651-52900651	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.997G>A; p.A333T; 12:52898884-52898884	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1214G>C; p.G405A; 12:52898508-52898508	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1126G>T; p.E376*; 12:52898755-52898755	urinary_tract; bladder	carcinoma	Substitution - Nonsense
c.1074C>T; p.A358A; 12:52898807-52898807	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.755G>A; p.R252H; 12:52900001-52900001	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.755G>A; p.R252H; 12:52900001-52900001	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1425T>C; p.S475S; 12:52897455-52897455	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.52delC; p.R18fs*56; 12:52904930-52904930	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1425T>C; p.S475S; 12:52897455-52897455	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1425T>C; p.S475S; 12:52897455-52897455	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.1425T>C; p.S475S; 12:52897455-52897455	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.1398C>T; p.I466I; 12:52897482-52897482	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1398C>T; p.I466I; 12:52897482-52897482	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.1398C>T; p.I466I; 12:52897482-52897482	thyroid	other; neoplasm	Substitution - coding silent
c.1063G>A; p.E355K; 12:52898818-52898818	skin	malignant_melanoma	Substitution - Missense
c.230T>G; p.V77G; 12:52904752-52904752	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1445C>T; p.P482L; 12:52897435-52897435	skin	malignant_melanoma	Substitution - Missense
c.657C>T; p.D219D; 12:52900621-52900621	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.219G>A; p.L73L; 12:52904763-52904763	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.654C>T; p.T218T; 12:52900624-52900624	skin	malignant_melanoma	Substitution - coding silent
c.44C>T; p.S15F; 12:52904938-52904938	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1207G>A; p.E403K; 12:52898515-52898515	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1239G>A; p.T413T; 12:52898483-52898483	skin	malignant_melanoma	Substitution - coding silent
c.658G>A; p.E220K; 12:52900620-52900620	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; plasma_cell_myeloma	Substitution - Missense
c.1300G>A; p.G434S; 12:52897580-52897580	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1014C>T; p.A338A; 12:52898867-52898867	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation