High levels of Max and stress-induced NFkappaB activation may result in elevated expression of Fas ligand in human lung cancer cells and possibly contribute to Fas ligand-associated immune escape mechanisms.

FASL polymorphisms contribute to susceptibility of lung cancer.

These results suggest that the FAS-1377G>A and -670A>G and FASL-844C>T polymorphisms do not significantly affect the susceptibility to lung cancer in Koreans.

Polymorphisms in the FASL is associated with early stage non-small cell lung cancer.

Celastrol can induce apoptosis of human non-small-cell lung cancer A549 cells through activation of both mitochondria- and Fas/FasL-mediated pathways.

Non-small-cell lung cancer patients carrying XRCC1 Arg194Arg, FAS-1377GG, and FASL-844T allele displayed completely no response to platinum based drugs.

FasL -844 SNP is associated with the susceptibility of pulmonary AD in age <60 years people. Fas -1377 SNP may modify the association of FasL -844 SNP with the risk of pulmonary adenocarcinoma.

FasL has a role in preventing tumor promotion in mouse Lewis lung cancer

Increased FasL expression is thought to be a basis for the immune evasion in non-small cell lung carcinomas.

Apoptotic defects in lung cancer cells are positively correlated with FasL expression .lung cancer cells express low Mal (TIRAP) levels that contributes to FasL mRNA decay through impairing TDP-43 expression.