lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	356
Symbol	FASLG
Synonymous	ALPS1B\|APT1LG1\|APTL\|CD178\|CD95-L\|CD95L\|FASL\|TNFSF6
Full name	Fas ligand (TNF superfamily, member 6)
Gene description	CD95 ligand\|apoptosis (APO-1) antigen ligand 1\|apoptosis antigen ligand\|fas antigen ligand\|tumor necrosis factor ligand superfamily member 6
Cytoband	1q23
Gene type	protein-coding
Synonymous	MIM:134638; HGNC:HGNC:11936; Ensembl:ENSG00000117560; HPRD:00610; Vega:OTTHUMG00000034841

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.820A>G; p.T274A; 1:172665990-172665990	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.395-1G>A; p.?; 1:172664333-172664333	skin	malignant_melanoma	Unknown
c.822G>T; p.T274T; 1:172665992-172665992	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.180G>A; p.P60P; 1:172659381-172659381	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.180G>A; p.P60P; 1:172659381-172659381	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.388C>G; p.Q130E; 1:172660134-172660134	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.470C>A; p.S157Y; 1:172665640-172665640	breast	carcinoma	Substitution - Missense
c.415G>A; p.E139K; 1:172664354-172664354	skin	malignant_melanoma	Substitution - Missense
c.755C>A; p.T252N; 1:172665925-172665925	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.175C>A; p.P59T; 1:172659376-172659376	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.661G>A; p.D221N; 1:172665831-172665831	skin	malignant_melanoma	Substitution - Missense
c.661G>A; p.D221N; 1:172665831-172665831	skin	malignant_melanoma	Substitution - Missense
c.92C>A; p.P31H; 1:172659293-172659293	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.655C>A; p.P219T; 1:172665825-172665825	liver	carcinoma	Substitution - Missense
c.655C>A; p.P219T; 1:172665825-172665825	liver	carcinoma	Substitution - Missense
c.587A>G; p.Y196C; 1:172665757-172665757	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.801C>T; p.V267V; 1:172665971-172665971	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - coding silent
c.801C>T; p.V267V; 1:172665971-172665971	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.200C>T; p.P67L; 1:172659401-172659401	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.822G>A; p.T274T; 1:172665992-172665992	breast	carcinoma; ER-PR-positive_carcinoma	Substitution - coding silent
c.46G>T; p.D16Y; 1:172659247-172659247	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.655C>T; p.P219S; 1:172665825-172665825	oesophagus	carcinoma	Substitution - Missense
c.243G>T; p.L81L; 1:172659444-172659444	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.337G>A; p.E113K; 1:172659538-172659538	skin	malignant_melanoma	Substitution - Missense
c.293G>T; p.G98V; 1:172659494-172659494	central_nervous_system; brain	glioma	Substitution - Missense
c.295C>T; p.L99L; 1:172659496-172659496	skin	malignant_melanoma	Substitution - coding silent
c.670A>G; p.M224V; 1:172665840-172665840	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.495C>A; p.T165T; 1:172665665-172665665	central_nervous_system; brain	glioma	Substitution - coding silent
c.766C>T; p.H256Y; 1:172665936-172665936	cervix	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.59G>A; p.S20N; 1:172659260-172659260	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.378T>G; p.S126S; 1:172660124-172660124	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.469T>C; p.S157P; 1:172665639-172665639	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.553G>A; p.E185K; 1:172665723-172665723	skin	malignant_melanoma	Substitution - Missense
c.177G>A; p.P59P; 1:172659378-172659378	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.177G>A; p.P59P; 1:172659378-172659378	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.541C>T; p.L181F; 1:172665711-172665711	skin	malignant_melanoma	Substitution - Missense
c.199C>A; p.P67T; 1:172659400-172659400	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.46G>A; p.D16N; 1:172659247-172659247	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.499G>A; p.G167R; 1:172665669-172665669	skin	malignant_melanoma	Substitution - Missense
c.499G>A; p.G167R; 1:172665669-172665669	skin	malignant_melanoma	Substitution - Missense
c.623G>A; p.S208N; 1:172665793-172665793	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.464_465insA; p.R156fs*22; 1:172665634-172665635	large_intestine; colon	carcinoma; adenocarcinoma	Insertion - Frameshift
c.533A>T; p.K178M; 1:172665703-172665703	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.140C>G; p.P47R; 1:172659341-172659341	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.595G>A; p.G199S; 1:172665765-172665765	skin; face	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.719C>T; p.A240V; 1:172665889-172665889	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.15C>T; p.F5F; 1:172659216-172659216	skin	malignant_melanoma	Substitution - coding silent
c.803A>T; p.N268I; 1:172665973-172665973	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.51C>T; p.S17S; 1:172659252-172659252	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.210C>A; p.P70P; 1:172659411-172659411	central_nervous_system; brain	glioma	Substitution - coding silent
c.242T>C; p.L81P; 1:172659443-172659443	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2T>A; p.M1K; 1:172659203-172659203	pancreas	carcinoma	Substitution - Missense
c.515C>T; p.S172F; 1:172665685-172665685	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.515C>T; p.S172F; 1:172665685-172665685	skin	malignant_melanoma	Substitution - Missense
c.394G>C; p.G132R; 1:172660140-172660140	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.131G>A; p.R44K; 1:172659332-172659332	skin	malignant_melanoma	Substitution - Missense
c.594G>A; p.R198R; 1:172665764-172665764	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.169C>T; p.P57S; 1:172659370-172659370	skin	malignant_melanoma	Substitution - Missense
c.776T>G; p.V259G; 1:172665946-172665946	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.487G>A; p.E163K; 1:172665657-172665657	skin	malignant_melanoma	Substitution - Missense
c.233G>T; p.S78I; 1:172659434-172659434	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.233G>T; p.S78I; 1:172659434-172659434	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.810G>A; p.E270E; 1:172665980-172665980	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.559G>A; p.G187R; 1:172665729-172665729	skin	malignant_melanoma	Substitution - Missense
c.840G>A; p.K280K; 1:172666010-172666010	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.416delA; p.K141fs*3; 1:172664355-172664355	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.416delA; p.K141fs*3; 1:172664355-172664355	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.759T>G; p.S253R; 1:172665929-172665929	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.294C>A; p.G98G; 1:172659495-172659495	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.641G>A; p.R214K; 1:172665811-172665811	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.806T>G; p.F269C; 1:172665976-172665976	endometrium	carcinoma; serous_carcinoma	Substitution - Missense
c.687G>A; p.M229I; 1:172665857-172665857	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.517G>C; p.G173R; 1:172665687-172665687	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.382G>A; p.E128K; 1:172660128-172660128	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.650A>C; p.K217T; 1:172665820-172665820	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.216G>A; p.K72K; 1:172659417-172659417	skin	malignant_melanoma	Substitution - coding silent
c.183A>G; p.P61P; 1:172659384-172659384	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.583G>T; p.V195L; 1:172665753-172665753	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.602C>A; p.S201Y; 1:172665772-172665772	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.413C>A; p.P138H; 1:172664352-172664352	liver	carcinoma	Substitution - Missense
c.413C>A; p.P138H; 1:172664352-172664352	liver	carcinoma	Substitution - Missense
c.307C>A; p.Q103K; 1:172659508-172659508	breast	carcinoma	Substitution - Missense
c.575A>T; p.Y192F; 1:172665745-172665745	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.481G>A; p.E161K; 1:172665651-172665651	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.152C>T; p.P51L; 1:172659353-172659353	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.846A>C; p.*282Y; 1:172666016-172666016	lung; right_upper_lobe	carcinoma; adenocarcinoma	Nonstop extension
c.432G>A; p.R144R; 1:172664371-172664371	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.664C>T; p.L222L; 1:172665834-172665834	skin	malignant_melanoma	Substitution - coding silent
c.763G>A; p.D255N; 1:172665933-172665933	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.763G>A; p.D255N; 1:172665933-172665933	skin	malignant_melanoma	Substitution - Missense
c.592C>T; p.R198W; 1:172665762-172665762	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.512T>C; p.L171P; 1:172665682-172665682	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.512T>C; p.L171P; 1:172665682-172665682	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.512T>C; p.L171P; 1:172665682-172665682	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.300G>A; p.G100G; 1:172659501-172659501	skin	malignant_melanoma	Substitution - coding silent
c.512T>C; p.L171P; 1:172665682-172665682	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.512T>C; p.L171P; 1:172665682-172665682	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.512T>C; p.L171P; 1:172665682-172665682	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.512T>C; p.L171P; 1:172665682-172665682	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.512T>C; p.L171P; 1:172665682-172665682	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation